Abstract:
:Chemical diversity is vital to antitubercular drug discovery as it ensures a novel bioactivity profile. Marine sponges have so far provided more than 1000 new bioactive molecules. Ethyl acetate extract of the marine sponge Dendrilla nigra on bioactivity-guided screening yielded three new compounds denigrins A-C, with potent antitubercular activity. Spectral and chemical analyses confirmed that these three compounds belong to the 3,4-diaryl pyrrole alkaloid category. The presence of monohydroxy substitution on benzene rings is not very common in lamellarin and related 3,4-diaryl pyrrole alkaloids isolated from marine invertebrates. Among these, denigrin C showed highest potency (minimum inhibitory concentration 4 μg/mL) against Mycobacterium tuberculosis H37Rv.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Murali Krishna Kumar M,Devilal Naik J,Satyavathi K,Ramana H,Raghuveer Varma P,Purna Nagasree K,Smitha D,Venkata Rao Ddoi
10.1080/14786419.2014.891112subject
Has Abstractpub_date
2014-01-01 00:00:00pages
888-94issue
12eissn
1478-6419issn
1478-6427journal_volume
28pub_type
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