Denigrins A-C: new antitubercular 3,4-diarylpyrrole alkaloids from Dendrilla nigra.

Abstract:

:Chemical diversity is vital to antitubercular drug discovery as it ensures a novel bioactivity profile. Marine sponges have so far provided more than 1000 new bioactive molecules. Ethyl acetate extract of the marine sponge Dendrilla nigra on bioactivity-guided screening yielded three new compounds denigrins A-C, with potent antitubercular activity. Spectral and chemical analyses confirmed that these three compounds belong to the 3,4-diaryl pyrrole alkaloid category. The presence of monohydroxy substitution on benzene rings is not very common in lamellarin and related 3,4-diaryl pyrrole alkaloids isolated from marine invertebrates. Among these, denigrin C showed highest potency (minimum inhibitory concentration 4 μg/mL) against Mycobacterium tuberculosis H37Rv.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Murali Krishna Kumar M,Devilal Naik J,Satyavathi K,Ramana H,Raghuveer Varma P,Purna Nagasree K,Smitha D,Venkata Rao D

doi

10.1080/14786419.2014.891112

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

888-94

issue

12

eissn

1478-6419

issn

1478-6427

journal_volume

28

pub_type

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