Abstract:
:The chemical investigation of the leaves and stem bark of Acacia polyacantha (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A 1 together with fifteen known compounds. Their structures were established from spectral , mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound 1 and the analogues 8 as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes. Unlike the analogue 8, compound 1 as well as doxorubicin displayed cytotoxic effects in all the 9 tested cancer cell lines with IC50 values ranged from 8.90 μM (towards CCRF-CEM leukemia cells) to 35.21 μM (towards HepG2 hepatocarcinoma cells) for compound 1 and from 0.02 μM (towards CCRF-CEM leukemia cells) to 66.83 μM (against CEM/ADR5000 leukemia cells) for doxorubicin.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Fotso W G,Na-Iya J,Mbaveng T A,Ango Yves P,Demirtas I,Kuete V,Samuel Y,Ngameni B,Efferth T,Ngadjui T Bdoi
10.1080/14786419.2018.1486312subject
Has Abstractpub_date
2019-12-01 00:00:00pages
3521-3526issue
24eissn
1478-6419issn
1478-6427journal_volume
33pub_type
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