Abstract:
:Acetylcholinesterase (AChE) inhibitors have been used for the symptomatic treatment of Alzheimer's disease. Eleven whole plants from Panama belonging to the Lycopodiaceae family have been screened for their anticholinesterase inhibitory and antioxidant activities by a thin-layer chromatography (TLC) bioautography method. Of these, only Lycopodium clavatum subsp. clavatum showed strong AChE inhibition. Seven plant extracts showed moderate inhibition, two of them, Huperzia cf chamaeleon and Huperzia reflexa, also possessed an antioxidant activity. This is the first report of anticholinesterase and antioxidant activities in these two native plants. Additionally, alkaloid extracts of the Lycopodiaceae plants were also analysed by TLC and LC-MS to identify the well-known AchE inhibitor, huperzine A. Two plants, H. cf chamaeleon and H. reflexa var. minor, showed the presence of huperzine.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Calderón AI,Simithy-Williams J,Sanchez R,Espinosa A,Valdespino I,Gupta MPdoi
10.1080/14786419.2012.701217subject
Has Abstractpub_date
2013-03-01 00:00:00pages
500-5issue
4-5eissn
1478-6419issn
1478-6427journal_volume
27pub_type
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