Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors.

abstract：:The objective of this study was to determine whether endophytic fungi, isolated from Kadsura angustifolia produce nigranoic acid and its highly oxygenated derivatives. From the 426 endophytic fungi screened, Trichoderma harzianum SWUKD3.1610 was detected to have a component with the same TLC R ...

journal_title：Natural product research

authors： Han M,Qin D,Ye T,Yan X,Wang J,Duan X,Dong J

更新日期：2019-07-01 00:00:00

abstract：:The dichloromethane extracts of the leaves, stem bark, bark and the roots of the three species of the primitive endemic genus Hortonia, H. angustifolia, H. floribunda and H. ovalifolia, collected from nine geographical locations ranging from lower elevations (84-420 m) to higher (2000 m) showed comparable HPLC profile...

journal_title：Natural product research

authors： Ratnayake R,Ratnayake Bandara BM,Wijesundara S,Macleod JK,Simmonds P,Karunaratne V

更新日期：2008-01-01 00:00:00

abstract：:The phytochemical study of the aerial parts of Viburnum chinshanense Graebn., a species growing in Western and Central China, led to the isolation of six iridoid glucosides: the novel 10,2'-diacetylpatrinoside, 1, and the known 2'-acetyldihydropenstemide, 2'-trans- p-coumaroyl-dihydropenstemide, 2'-acetylpatrinoside, ...

journal_title：Natural product research

authors： Tomassini L,Gao J,Foddai S,Serafini M,Ventrone A,Nicoletti M

更新日期：2006-07-10 00:00:00

abstract：:One known bis-indole alkaloid-voacamine was isolated from Voacanga africana Stapf and Surface Plasmon Resonance imaging (SPRi) exprement showed that this alkaloid could be combine with Protein Tyrosine Phosphatase1B (PTP1B). Then the PTP1B activity inhibition experiment display that the compound showed an outstanding ...

journal_title：Natural product research

authors： Wang YQ,Li HX,Liu XC,Zhao JS,Liu RQ,Huai WY,Ding WJ,Zhang TE,Deng Y

更新日期：2019-12-01 00:00:00

abstract：:In the case of Achillea wilhelmsii, 30 compounds were identified representing 94.48% of the total oil with a yield of 0.82% w/w. The major constituents of the oil were described as α-thujene (6.11%), α-pinene (5.11%), sabinene (5.23%), p-cymene (7%), 1,8-cineole (6%), linalool (10%), camphor (8.43%), thymol (18.98%) a...

journal_title：Natural product research

authors： Kazemi M,Rostami H

更新日期：2015-02-01 00:00:00

abstract：:Endophytic fungi represent ubiquitous microbial organisms able to live in the tissues of different plants around the world and represent a prolific source of bioactive metabolites. In the present study, the endophytic fungus Aspergillus calidoustus was isolated from the medicinal plant Acanthospermum australe (Asterac...

journal_title：Natural product research

authors： de Carvalho CR,Vieira Mde L,Cantrell CL,Wedge DE,Alves TM,Zani CL,Pimenta RS,Sales Junior PA,Murta SM,Romanha AJ,Rosa CA,Rosa LH

更新日期：2016-01-01 00:00:00

abstract：:Two Streptomyces spp. strains responsible for potato common scab infections in Uruguay which do not produce diketopiperazines were identified through whole-genome sequencing, and the virulence factor produced by one of them was isolated and characterized. Phylogenetic analysis showed that both pathogenic strains can b...

journal_title：Natural product research

authors： Lapaz MI,López A,Huguet-Tapia JC,Pérez-Baldassari MF,Iglesias C,Loria R,Moyna G,Pianzzola MJ

更新日期：2019-10-01 00:00:00

abstract：:A series of unexpected triterpenic C17-[5-methyl-1,3]-oxazoles along with targeted N-propargylamides was synthesized by an interaction of acid chlorides with propargylamine hydrochloride. We proposed that the formation of methyl oxazole passes through an alternative pathway by the participation of the terminal alkyne ...

journal_title：Natural product research

authors： Khusnutdinova EF,Petrova AV,Lobov AN,Kukovinets OS,Baev DS,Kazakova OB

更新日期：2020-03-28 00:00:00

abstract：:Four flavone compounds were isolated from the effective fractions inhibiting xanthine oxidase (XOD) of the medicinal plant Selaginella labordei with anti-virus activity, and the structures were elucidated as 4'-methylether robustaflavone (1), robustaflavone (2), eriodictyol (3) and amentoflavone (4). The 50% inhibitor...

journal_title：Natural product research

authors： Tan WJ,Xu JC,Li L,Chen KL

更新日期：2009-01-01 00:00:00

abstract：:New isoquinoline alkaloid hypepontine (1) together with a five known compounds, were identified in Hypecoum ponticum Velen, the partial synonym of Hypecoum procumbens L. The structure of the new substance was elucidated based on spectroscopic evidence. The tertiary and quaternary alkaloid mixtures as well as the isola...

journal_title：Natural product research

authors： Doncheva T,Kostova N,Valcheva V,Toshkovska R,Vutov V,Philipov S

更新日期：2020-03-01 00:00:00

abstract：:Accumulating evidences have shown the beneficial effects of natural products for Alzheimer's disease (AD) treatment. The present study was designed to investigate the neuroprotective effects of secondary metabolites of Galactomyces geotrichum (SMGG) on D-galactose induced AD mice. SMGG was extracted and its toxicologi...

journal_title：Natural product research

authors： Wang F,Wang F,Chen T

更新日期：2020-04-15 00:00:00

abstract：:One new triterpenoid olean-18-ene-1β, 2α, 3β-triol (1) along with four known compounds were isolated from the chloroform extract of the aerial part of Salvia atropatana Bunge. The known compounds were two flavonoids, 5-hydroxy-7,4'-dimethoxyflavone (2) and 5-hydroxy-6,7,4'-trimethoxyflavone (3), an abietane-type diter...

journal_title：Natural product research

authors： Habibi Z,Cheraghi Z,Ghasemi S,Yousefi M

更新日期：2012-01-01 00:00:00

abstract：:Two new ditetrahydrofuran lignans, named sieverlignans A and B (1 and 2), together with six known ones (3-8), were isolated from the aerial parts of Artemisia sieversiana. Their structures were established on the basis of spectroscopic analysis including HRMS, NMR spectra and circular dichroism experiments. All the co...

journal_title：Natural product research

authors： Zhou XD,Xu XW,Shi LY,Chen SH,Zeng KW,Tu PF

更新日期：2020-01-13 00:00:00

abstract：:The search for bioactive natural products from the rhizomes of Paris polyphylla (Trilliaceae) has resulted in the isolation of four known constituents, 1,5-dihydroxy-7-methoxy-3-methylanthraquinone (1), diosgenin-3-O-[alpha-L-rhamnopyranosyl-(1 --> 3)-beta-D-glucopyranoside] (2), diosgenin-3-O-[alpha-L-rhamnopyranosyl...

journal_title：Natural product research

authors： Devkota KP,Khan MT,Ranjit R,Lannang AM,Samreen,Choudhary MI

更新日期：2007-04-01 00:00:00

abstract：:Chemical investigation of the Red Sea sponge Dragmacidon coccinea led to the isolation of a new nucleoside, dragmacidoside (1), along with eight known compounds: adenosine (2), inosine (3), deoxycytidine (4), methyl-α-d-glucopyranoside (5), clionasterol (6), stigmasterol (7), campesterol (8) and brassicasterol (9). Th...

journal_title：Natural product research

authors： Abou-Hussein DR,Badr JM,Youssef DT

更新日期：2014-01-01 00:00:00

abstract：:Three new aconitine-type C19-diterpenoid alkaloids, taipeinines A-C (1-3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8...

journal_title：Natural product research

authors： Guo ZJ,Xu Y,Zhang H,Li MY,Xi K

更新日期：2014-01-01 00:00:00

abstract：:Ginsenoside Re (G-Re) is a major ingredient of the ginseng bud. A novel and rapid method to isolate and purify G-Re from ginseng buds was established. The procedure involves solvent extraction of ginseng bud powder, then pre-purification with an active carbon column and purification by preparative HPLC (prep-HPLC). Ac...

journal_title：Natural product research

authors： Kuang P,Wang G,Yuan Q,Liang H

更新日期：2012-01-01 00:00:00

abstract：:The methanolic extract of the Tanacetum gracile afforded the isolation of new sesquiterpene lactone, named gracilone (1) along with four known compounds as 14α-taraxeran-3-one (2), 14α-taraxeran-3-ol (3), apigenin (4) and β-sitosterol (5). The structure of compound 1 was elucidated on the basis of 1D, 2D NMR and MS sp...

journal_title：Natural product research

authors： Bhat G,Masood A,Ganai BA,Hamza B,Ganie S,Shafi T,Idris A,Shawl AS,Tantry MA

更新日期：2016-10-01 00:00:00

abstract：:A new β-tetralonyl glucoside, methylberchemiaside (1), along with five known compounds (2-6) were isolated from a fungus Colletotrichum sp . GDMU-1 derived from the leaves of Santalum album. Their structures were determined by detailed analysis of spectroscopic data. All compounds were tested for the inhibitory effect...

journal_title：Natural product research

authors： Liu W,Chen S,Li J,Yang X,Yan C,Liu H

更新日期：2019-02-01 00:00:00

abstract：:The use of a matrix solid-phase dispersion (MSPD) process to extract polyphenols from hawthorn (Crataegus oxyacantha L.) a deciduous shrub with an expected rich phytochemical profile, has been evaluated. MSPD extracts of fruits and leaves have an outstanding content of polyphenols, although the particular phenolic pro...

journal_title：Natural product research

authors： Benabderrahmane W,Lores M,Lamas JP,Benayache S

更新日期：2018-05-01 00:00:00

abstract：:Illicium lanceolatum is a popular aromatic and medicinal plant in China. Essential oil from the roots of I. lanceolatum, obtained by hydrodistillation, was analysed by GC-MS. The essential oil was dominated by phenylpropenes. The major components were myristicin (17.63%), α-asarone (17.23%), methyl isoeugenol (11.19%)...

journal_title：Natural product research

authors： Liang J,Huang B,Wang G

更新日期：2012-01-01 00:00:00

abstract：:4-Methoxybenzene-1-ONN-azoxyformamide (1), 4-methoxybenzene-1-azoformamide (2), 4-hydroxyben-zene-1-azoformamide (3) and 4-hydroxybenzene-1-ONN-azoxyformamide (4) were isolated from the fruiting bodies of Calvatia craniiformis and Lycoperdon hiemale, respectively. Compounds 1 and 4 showed radicle growth inhibitory act...

journal_title：Natural product research

authors： Kamo T,Kashiwabara M,Tanaka K,Ando S,Shibata H,Hirota M

更新日期：2006-05-10 00:00:00

abstract：:New analogues of a long-chain secondary alcohol (1) and laserine (2) were isolated from the flowers of Tamarix hampeana L. The isolated compounds were identified using 1D and 2D NMR, LCMS/APCI, and chemical methods. Laserine was isolated for the first time from T. hampeana L. ...

journal_title：Natural product research

authors： Aykac A,Akgül Y

更新日期：2010-01-01 00:00:00

abstract：:Today's world is increasingly seeking ways to replace the synthetic drugs with the therapeutic power of natural products. This study was designed to investigate the protective effects of Foeniculum vulgare (FV) and Salvia officinalis (SO) waters infusions against carcinogen chemical trichloroacetic acid (TCA)-exposure...

journal_title：Natural product research

authors： Celik I,Isik I

更新日期：2008-01-10 00:00:00

abstract：:Fungi are important organisms related to the production of antibiotics, many of which are commercially available and used in the clinic to treat infections. Infectious diseases represent a leading cause of death worldwide, being a severe threat to public health, especially with the rise of multi-resistant microorganis...

journal_title：Natural product research

authors： Teles AP,Ataliba GS,Takahashi JA

更新日期：2013-01-01 00:00:00

abstract：:β-Glucan, derived from Saccharomyces cerevisiae, is a biological response modifier which affects the innate and adaptive immune responses. The CCR5 chemokine receptor is crucial for immune cell responses. In this study, the effects of the carboxymethylated form of β-glucan (CM-G) on the lymphocyte population of CCR5 g...

journal_title：Natural product research

authors： Magnani M,Castro-Gomez RH,Aoki MN,Gregório EP,Libos F Jr,Morimoto HK,Reiche EM,Watanabe MA

更新日期：2012-01-01 00:00:00

abstract：:One new xanthone, chryxanthone C (1), together with four known analogues (2-5), were isolated from the cultures of Paecilamyces sp. TE-540, an endophytic fungus obtained from the leaves of Nicotiana tabacum L. The structure of 1 was elucidated by comprehensive spectral analysis including HRESIMS and 1D/2D NMR, which w...

journal_title：Natural product research

authors： Li XQ,Dong QJ,Xu K,Yuan XL,Liu XM,Zhang P

更新日期：2020-10-04 00:00:00

abstract：:The natural product lupeol 1 was isolated from aerial parts of Vernonia scorpioides with satisfactory yield, which made it viable to be used as starting material in semisynthetic approach. Ten lupeol derivatives 2-11 were prepared by classical procedures. Including, five new esters derivatives 7-11, which were obtaine...

journal_title：Natural product research

authors： Machado VR,Sandjo LP,Pinheiro GL,Moraes MH,Steindel M,Pizzolatti MG,Biavatti MW

更新日期：2018-02-01 00:00:00

abstract：:Fructose feeding induces a rise in blood pressure in normal rats that is associated with insulin resistance, hyperinsulinemia, hyperglycaemia, hypercholesterolaemia and hypertriglyceridaemia. We have examined the effect of chronic administration of A-HRS (100 and 300 mg kg⁻¹; p.o.) isolated from Hibiscus rosa sinensis...

journal_title：Natural product research

authors： Mohan M,Khade B,Shinde A

更新日期：2012-01-01 00:00:00

abstract：:A new dehydrodigallic acid derivative (1), along with 19 known compounds, including 6 phenolic derivatives, 2 steroids and 11 triterpenoids were isolated from the ethanol extract of the root of Geum urbanum. Herein, there is the first report of steroid and triterpene in Geum urbanum. The purified metabolites were char...

journal_title：Natural product research

authors： Ton That Q,Nguyen Thien TV,Dang HP,Le Hoan N,Vo LKT,Nguyen MHD,Ngu NT,Nguyen TS,Hansen PE

更新日期：2018-11-01 00:00:00