Sesquiterpene-neolignans from Manglietia hookeri.

Abstract:

:The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), together with three lignans, obovatol (4), honokiol (5) and magnolol (6). Their structures were elucidated on the basis of spectral analysis and by comparison with related literature data. Compounds 1, 4-6 showed a protective effect on UV inductive DNA damage in mice lymphocyte cells, while compound 1 indicated the smallest Olive Tail Moment 7.34 ± 2.09 at 6 × 10(-6) μM.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Hu X,Sui X,Wang Y,Wang W,Wu H,Zhang F,Tan Y,Zhang F

doi

10.1080/14786419.2015.1110703

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

1477-83

issue

13

eissn

1478-6419

issn

1478-6427

journal_volume

30

pub_type

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