Abstract:
:The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), together with three lignans, obovatol (4), honokiol (5) and magnolol (6). Their structures were elucidated on the basis of spectral analysis and by comparison with related literature data. Compounds 1, 4-6 showed a protective effect on UV inductive DNA damage in mice lymphocyte cells, while compound 1 indicated the smallest Olive Tail Moment 7.34 ± 2.09 at 6 × 10(-6) μM.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Hu X,Sui X,Wang Y,Wang W,Wu H,Zhang F,Tan Y,Zhang Fdoi
10.1080/14786419.2015.1110703subject
Has Abstractpub_date
2016-07-01 00:00:00pages
1477-83issue
13eissn
1478-6419issn
1478-6427journal_volume
30pub_type
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