Two new 19-hydroxy bufadienolides with cytotoxic activity from the skins of Bufo melanosticus.

Abstract:

:Two new 19-hydroxy bufadienolides, named bufohydrolide A (1) and bufohydrolide B (2), and four known analogs (3-6) were isolated from the aqueous extracts of the skins of Bufo melanosticus. Their structures were established by spectral data analyses, such as UV, IR, 1 D/2D NMR and mass spectra. Compounds 1-6 were evaluated for their cytotoxic activity against SMMC-7721, HT-29 and A549 cells. Noteworthily, all six isolates exhibited various levels of anti-proliferative activities with IC50 values ranging from 0.02 ± 0.0002 to 25 ± 0.5 μM.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Meng L,Li S,Kong Q,Wang M,Zhang X,Zhu X,Yu W,Jiang N,Chun Z,Li N,Liu Y

doi

10.1080/14786419.2020.1741582

subject

Has Abstract

pub_date

2020-03-23 00:00:00

pages

1-7

eissn

1478-6419

issn

1478-6427

pub_type

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