(±) Benzomalvins E isolated from Penicillium sp. SYPF 8411 in the rhizosphere soil of Codonopsis clematidea.

Abstract:

:(+) Benzomalvins E (1) and (-) Benzomalvins E (2), a pair of epimeric derivatives, together with three known benzomalvins (3-5), were isolated from solid cultures of a interrhizospheric fungus Penicillium sp. SYPF 8411. The planar structure of (+) Benzomalvins E (1) has been previously reported. While, the absolute configuration of compound 1 was established by X-ray crystallographic analysis for the first time. The planar structure of the new compound 2 were elucidated by detailed interpretation of their HR ESI-TOF MS and NMR spectroscopic data. The absolute configuration of compound 2 was established by Rh2(OCOCF3)4-induced CD spectral data and the electronic circular dichroic (ECD) method. Furthermore, the epimerization induced by pH, temperature and H2O was revealed. Benzomalvins (1-3, 5), a type of indoximod, enhanced the cytotoxic capability of 5-fluorouracil against A549.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Feng QM,Feng Y,Zhang TY,Wang HF,Zhang MY,Wu YY,Chen G,Zhang YX,Pei YH

doi

10.1080/14786419.2019.1569004

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

1884-1890

issue

13

eissn

1478-6419

issn

1478-6427

journal_volume

34

pub_type

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