Dragmacidoside: a new nucleoside from the Red Sea sponge Dragmacidon coccinea.

Abstract:

:Chemical investigation of the Red Sea sponge Dragmacidon coccinea led to the isolation of a new nucleoside, dragmacidoside (1), along with eight known compounds: adenosine (2), inosine (3), deoxycytidine (4), methyl-α-d-glucopyranoside (5), clionasterol (6), stigmasterol (7), campesterol (8) and brassicasterol (9). The compounds were isolated from chloroform and ethyl acetate fractions of the methanolic extract of the sponge, and their structures were established based on various spectroscopic data including MS, 1D and 2D NMR (COSY, HSQC and HMBC). Biological testing revealed that the chloroform fraction possesses significant anti-inflammatory activity in the carrageenan-induced hind paw oedema in rats.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Abou-Hussein DR,Badr JM,Youssef DT

doi

10.1080/14786419.2014.915828

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

1134-41

issue

15

eissn

1478-6419

issn

1478-6427

journal_volume

28

pub_type

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