Abstract:
:Chemical investigation of the Red Sea sponge Dragmacidon coccinea led to the isolation of a new nucleoside, dragmacidoside (1), along with eight known compounds: adenosine (2), inosine (3), deoxycytidine (4), methyl-α-d-glucopyranoside (5), clionasterol (6), stigmasterol (7), campesterol (8) and brassicasterol (9). The compounds were isolated from chloroform and ethyl acetate fractions of the methanolic extract of the sponge, and their structures were established based on various spectroscopic data including MS, 1D and 2D NMR (COSY, HSQC and HMBC). Biological testing revealed that the chloroform fraction possesses significant anti-inflammatory activity in the carrageenan-induced hind paw oedema in rats.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Abou-Hussein DR,Badr JM,Youssef DTdoi
10.1080/14786419.2014.915828subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1134-41issue
15eissn
1478-6419issn
1478-6427journal_volume
28pub_type
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