Abstract:
:This study describes the in vitro inhibition of protein denaturation of extract/fractions of Withania somnifera and isolated withanolides including 20β hydroxy-1-oxo(22R)-witha-2,5,24 trienolide (1), (20R,22R-14α,20α)-dihydroxy-1-oxowitha-2,5,16,24 tetraenolide (2). The results showed that the extract/fractions of the plant evoked profound inhibitory effect on thermal-induced protein denaturation. The chloroform fraction caused the most dominant attenuation of 68% at 500 μg/mL. The bioactivity-guided isolation from chloroform fraction led to the isolation of compounds 1 and 2 that showed profound protein inhibition with 78.05% and 80.43% effect at 500 μg/mL and thus strongly complimented the activity of extract/fractions. In conclusion, extract/fractions of W. somnifera possessed strong inhibition of protein denaturation that can be attributed to these isolated withanolides.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Khan MA,Khan H,Rauf A,Ben Hadda Tdoi
10.1080/14786419.2015.1007138subject
Has Abstractpub_date
2015-01-01 00:00:00pages
2318-21issue
24eissn
1478-6419issn
1478-6427journal_volume
29pub_type
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