Pharmaceutical potential of phorbol esters from Jatropha curcas oil.

Abstract:

:Phorbol esters (PEs) are diterpenes present in Jatropha curcas L. seeds and have a myriad of biological activities. Since PEs are toxic, they are considered to be futile in Jatropha-based biodiesel production chain. In the present study, the extracted PEs from Jatropha oil were used as a starting material to synthesise pharmacologically important compound, prostratin. The prostratin synthesised from Jatropha showed identical mass with that of the reference standard prostratin, as determined by Nano-LC-ESI-MS/MS. Considering the rapid growth in Jatropha biodiesel industry, potential exists to harness large amount of PEs which can be further utilised to synthesise prostratin as a value added product.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Devappa RK,Malakar CC,Makkar HP,Becker K

doi

10.1080/14786419.2012.716057

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

1459-62

issue

16

eissn

1478-6419

issn

1478-6427

journal_volume

27

pub_type

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