Myrcia hatschbachii: antifungal activity and structural elucidation of ellagic and 3-O-methyl ellagic acids.

Abstract:

:Natural products, especially plants, have been investigated as sources of new substances with antimicrobial properties. In this context, the Myrcia genus is extensively researched for presenting such activities. This work aims to evaluate the antifungal, antibacterial, and antioxidant properties of extracts and fractions of stems of Myrcia hatschbachii, also to characterize two phenolic compounds. The antibacterial and antifungal activities were assessed by using the broth microdilution method. The ethyl acetate fraction (FGA) inhibited the growth of Candida albicans at a Minimum Inhibitory Concentration (MIC) of 15.6 µg/mL, presented 40% of phenolic compounds in its composition, obtained the most significant results in antioxidant methods (DPPH, FRAP, ABTS), besides the identification of ellagic and 3-O-methyl ellagic acids by NMR. Considering the relevant antifungal activity revealed by the fraction, new studies can be carried out to encourage the continuous search for antifungal alternatives.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Gatto LJ,Veiga A,Gribner C,Moura PF,Rech KS,Murakami FS,Dias JFG,Miguel OG,Miguel MD

doi

10.1080/14786419.2020.1793149

subject

Has Abstract

pub_date

2020-07-13 00:00:00

pages

1-4

eissn

1478-6419

issn

1478-6427

pub_type

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