Endertiins A-B, two lanostane triterpenoids from the fruit bodies of the mushoom Humphreya endertii.

Abstract:

:Two new lanostane triterpnenoids named endertiins A and B (1 and 2) together with two known compounds as ganodecalone A (3) and ergosterol (4) have been successfully isolated from the cultivated fruit bodies of the mushroom Humphreya endertii Stey (Ganodermataceae). Their structures were elucidated by a combination of HR-MS and 2 D NMR spectroscopic analyses. In addition, endertiins A and B (1 and 2) were evaluated their cytotoxicity against two cancer cell lines, MCF7 (human breast carcinoma) and LU (human lung carcinoma). The result showed that endertiin A (1) could inhibit the growth of MCF-7 cells with its IC50 value of 71.16 ± 6.25 µg/ml.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Quang DN,Long LD,Tung NQ,Thanh NN,Tham LX

doi

10.1080/14786419.2020.1800696

subject

Has Abstract

pub_date

2020-08-03 00:00:00

pages

1-6

eissn

1478-6419

issn

1478-6427

pub_type

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