Abstract:
:This study was aimed at characterising the secondary metabolites responsible for antibacterial and antioxidant activities of Acalypha wilkesiana. Purification of the defatted methanol leaves extract was guided by the DPPH free radical scavenging assay as well as by evaluation of the antibacterial activity against four bacterial strains. As a result, geraniin, corilagin, quadrangularic acid M and shikimic acid were purified and isolated. Shikimic acid, reported for the first time from this plant, proved to be the major metabolite of the extract. All the four isolated compounds showed bactericidal activity against extended spectrum beta-lactamase-producing Klebsiella pneumoniae (700603), while corilagin was the single compound to exhibit antioxidant activity (IC50 53 μg/mL).
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Anokwuru CP,Sinisi A,Samie A,Taglialatela-Scafati Odoi
10.1080/14786419.2014.983105subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1180-3issue
12eissn
1478-6419issn
1478-6427journal_volume
29pub_type
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