New anthraquinone and eurotinone analogue from the seeds of Senna obtusifolia and their inhibitory effects on human organic anion transporters 1 and 3.

Abstract:

:A continuous phytochemical study on the seeds of Senna obtusifolia (Syn.: Cassia obtusifolia) led to the isolation of a new anthraquinone analogue, obtusifolin-2-O-β-D-(6'-O-α,β-unsaturated butyryl)-glucopyranoside (1) and a new eurotinone analogue, epi-9-dehydroxyeurotinone-β-D-glucopyranoside (2). Their structures were established mainly by NMR and MS experiments as well as the necessary chemical evidences. Their inhibitory effects on two organic anion transporters (OAT1 and OAT3) were investigated and the results showed that 1 exhibited a strongly specific inhibitory effect on OAT1 at 100 μM.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Pang X,Wang LM,Zhang YC,Kang LP,Yu HS,Fan GW,Han LF

doi

10.1080/14786419.2018.1480621

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

3409-3416

issue

23

eissn

1478-6419

issn

1478-6427

journal_volume

33

pub_type

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