Abstract:
:In this work, we report a rapid and convenient HPLC-UV-DAD method for the isolation of δ-T3 on semi-preparative scale from two different vitamin E rich processed, commercially available products obtained from the fruits of Elaeis guineensis Jacq. (oil palm) and from the seeds of Bixa orellana L. (achiote tree). Chromatography was run using reverse phase (RP) C-18 columns and HPLC-grade acetonitrile as mobile phase. The purity of the isolated δ-T3, assessed by GC-MS and 1H NMR was above 98%. The δ-T3 cytotoxic activity found in vitro against the proliferation of human A375 melanoma cells compared to that of the other δ-T3 free tocols mixture suggest its primary role in the experimental anticancer activity observed for palm oil derived products. Taken altogether, the results of this study highlight the importance of the application of suitable purification systems for the preparations of tocotrienols prior to their experimental or clinical testing.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Beretta G,Gelmini F,Fontana F,Moretti RM,Montagnani Marelli M,Limonta Pdoi
10.1080/14786419.2017.1320793subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1130-1135issue
10eissn
1478-6419issn
1478-6427journal_volume
32pub_type
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