Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production.

Abstract:

:A new bisabolane-type sesquiterpenoid, turmerone Q (1), along with six known compounds (2-7), were isolated from the rhizomes of Curcuma longa L. The structural elucidation of the new compound was conducted using 1H NMR, 13C NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of 1 was elucidated by comparison of the experimental and calculated ECD spectra. The anti-inflammatory effects of 1-7 were evaluated through lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages assays, and compounds 6 and 7 showed potent inhibitory activity against NO production.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Yuan T,Zhang C,Qiu C,Xia G,Wang F,Lin B,Li H,Chen L

doi

10.1080/14786419.2017.1354185

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

1887-1892

issue

16

eissn

1478-6419

issn

1478-6427

journal_volume

32

pub_type

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