In vitro antiviral activity of Ficus carica latex against caprine herpesvirus-1.

Abstract:

:The latex of Ficus carica Linn. (Moraceae) has been shown to possess antiviral properties against some human viruses. To determine the ability of F. carica latex (F-latex) to interfere with the infection of caprine herpesvirus-1 (CpHV-1) in vitro, F-latex was resuspended in culture media containing 1% ethanol and was tested for potential antiviral effects against CpHV-1. Titration of CpHV-1 in the presence or in the absence of F-latex was performed on monolayers of Madin Darby Bovine Kidney (MDBK) cells. Simultaneous addition of F-latex and CpHV-1 to monolayers of MDBK cells resulted in a significant reduction of CpHV-1 titres 3 days post-infection and this effect was comparable to that induced by acyclovir. The study suggests that the F-latex is able to interfere with the replication of CpHV-1 in vitro on MDBK cells and future studies will determine the mechanisms responsible for the observed antiviral activity.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Camero M,Marinaro M,Lovero A,Elia G,Losurdo M,Buonavoglia C,Tempesta M

doi

10.1080/14786419.2014.918120

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

2031-5

issue

22

eissn

1478-6419

issn

1478-6427

journal_volume

28

pub_type

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