Rauvolfianine, a new antimycobacterial glyceroglycolipid and other constituents from Rauvolfia caffra. Sond (Apocynaceae).

Abstract:

:The chemical investigation of the extract of the dried leaves of Rauvolfia caffra (Sond) (synonym Rauvolfia macrophylla) (Apocynaceae) led to isolation of a new glycoside derivative, rauvolfianine (1) as well as six known compounds: oleanolic acid (2), sitosterol-3-O-β-D-glucopyranoside (3), betulinic acid (4), vellosimine (5), sarpagine (6) and D-fructofuranosyl-β-(2→1)-α-D-glucopyranoside (7). Compounds 1, 2, 3, 4 and 7 were evaluated for antitubercular activity. Compounds 1 and 2 were the most active (MIC = 7.8125 and 31.25 μg/mL) towards the Isoniazid resistant strain of Mycobacterium tuberculosis AC45. Their structures and relative stereochemistry were elucidated by spectroscopic methods.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Ebeh Messanga R,Dominique Serge NB,Abouem A Zintchem A,Norbert MNI,Esther Del Florence MN,Patrick Hervé BD,Maximilienne Ascension N,Alex De Théodore A,Dieudonné Emmanuel P,Christian G B,Koert U

doi

10.1080/14786419.2017.1356832

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

1971-1976

issue

16

eissn

1478-6419

issn

1478-6427

journal_volume

32

pub_type

杂志文章
  • A new triterpenoid and other compounds from lichens Cryptothecia faveomaculata Makhija & Patw.

    abstract::Ten compounds (1-10) were purified from the extract of lichens C. faveomaculata, and among these one new triterpenoid, cryptothecin A (1) was characterized through mass spectrometric and 2D NMR spectroscopic analyses. Some of the isolated compounds were assessed for their antimicrobial (1, 6, and 8) and cytotoxic acti...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1648466

    authors: Ngoc Tuan N,Kuo PC,Trung Hieu T,Tuong Vi LN,Tong Hung Q,Dunge LT,Duy Trinh N,Quang Trung N,Cuu Khoa N,Viet Hai H,Thang TD

    更新日期:2019-08-02 00:00:00

  • Development and validation of headspace Solid-Phase microextraction coupled with gas chromatography (HS-SPME-GC) method for the analysis of zingiber zerumbet L.

    abstract::Headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography (GC-FID) was explored to determine the fingerprinting characteristic of Zingiber zerumbet L. volatiles to differentiate between different ginger species. The effect of different fibers [polydimethylsiloxane (PDMS, 7 μm), polyacrylate (PA, ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1643863

    authors: Bhavya ML,Ravi R,Madhava Naidu M

    更新日期:2019-07-22 00:00:00

  • Composition and antioxidant activity of the essential oil of Artemisia annua L.

    abstract::Artemisia annua L. is an annual Eurasian desert-steppe plant. The composition of essential oils found in Artemisia annua from Russian (Buryatian) flora was analyzed in this work using gas chromatography mass-spectrometry method. Artemisia ketone, β-selinene, caryophyllene, caryophyllene oxide, germacrene D were the ma...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1548461

    authors: Zhigzhitzhapova SV,Dylenova EP,Gulyaev SM,Randalova TE,Taraskin VV,Tykheev ZA,Radnaeva LD

    更新日期:2020-09-01 00:00:00

  • Characterisation of proanthocyanidins from Schisandra chinensis seed coats by UPLC-QTOF/MS.

    abstract::In this article, an ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry method was developed to detect the chemical structures of proanthocyanidins (PAs) from seed coats of Schisandra chinensis. The cleavage pathways of the compounds were revealed. The structures of S. chinensis PAs, in...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.950574

    authors: Yan T,Hu GS,Wang AH,Hong Y,Jia JM

    更新日期:2014-01-01 00:00:00

  • Two new isoflavone derivatives from the roots of an Egyptian collection of Lotus polyphyllos.

    abstract::Investigation of the roots of Lotus polyphyllos Clarke resulted in the isolation of two new isoflavone derivatives; 4'-O-methylerythrinin C (3) and 4'-O-methyl-2''-hydroxydihydroalpinumisoflavone (4). In addition, the three known isoflavone derivatives 4'-O-methylalpinumisoflavone (1) lupinalbin F (5), 4',7-dimethoxy-...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410500364627

    authors: Abdel-Kader MS,Amer ME,Tang S,Kingston DG

    更新日期:2006-08-01 00:00:00

  • A new cyclopeptide alkaloid from Clematis Florida.

    abstract::One new 14-membered ring cyclopeptide alkaloid, plenane A (1), along with six known compounds (2-7), was isolated from the roots of Clematis florida. Their structures were elucidated by means of NMR spectroscopic analysis and mass spectrometry. In addition, their anti- inflammatory effects on lipopolysaccharide-induce...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1809399

    authors: Wu Y,Zhang YF,Zhang HT,Ma XH,Yang NN,Feng SB,Zhong TH,Zhang YH

    更新日期:2020-08-18 00:00:00

  • Cytotoxic effect of pure compounds from Piper rivinoides Kunth against oral squamous cell carcinoma.

    abstract::The oral squamous cell carcinoma (OSCC) is the eighth more common cancer in men. The development of new and more efficient drugs is needed. Plants of the genus Piper are popularly used in the treatment of many diseases. This study evaluated the antitumor effect of extract, fraction and isolated compounds from leaves o...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1831494

    authors: Fonseca ACCD,de Queiroz LN,Sales Felisberto J,Jessé Ramos Y,Mesquita Marques A,Wermelinger GF,Pontes B,de Lima Moreira D,Robbs BK

    更新日期:2020-10-14 00:00:00

  • New steroidal alkaloids from Sarcococca saligna.

    abstract::Two new steroidal alkaloids, salonine-A [(20S)-20-(N,N-dimethylamino)-3beta-(tigloylamino)-5alpha-pregn-14-en-2beta,4beta-diol] (1), and salonine-B [(20S)-20-(N,N-dimethylamino)-3beta-methoxy-pregn-5,16-diene] (2), were isolated from the MeOH extract of Sarcococca saligna, along with a known base, alkaloid-C (3). Thei...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/1057563021000051086

    authors: Atta-ur-Rahman,Feroz F,Zaheer-ul-Haq,Nawaz SA,Khan MR,Choudhary MI

    更新日期:2003-08-01 00:00:00

  • Phenolic and antioxidant profiles of rowan (Sorbus L.) fruits.

    abstract::Fruits of different Sorbus L. species have been traditionally used in food production and in the treatment of various ailments. Besides common antioxidant active phytochemicals such as ascorbic acid, tocopherols and carotenoids, fruits are rich in phenolic compounds that are of particular interest. In this study, prof...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.895727

    authors: Raudonis R,Raudonė L,Gaivelytė K,Viškelis P,Janulis V

    更新日期:2014-01-01 00:00:00

  • Chemical composition of Erycibe schmidtii and antiproliferative activity of scopoletin on immature dendritic cells.

    abstract::Immature dendritic cells (iDCs) play very important roles in the pathological process of rheumatoid arthritis (RA). Therefore, it is urgent to search for natural products with antiproliferative activity on iDCs for anti-RA drug discovery. Erycibe schmidtii, a traditional Chinese medicine, has been used to treat RA in ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1547292

    authors: Ren W,Wang Y,He Q,Zhou Y,Li C,Wang W,Leng X,Zeng T,Zou Q,Li L

    更新日期:2020-09-01 00:00:00

  • Anthraquinones from Morinda officinalis roots enhance adipocyte differentiation in 3T3-L1 cells.

    abstract::To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining. Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several ch...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2011.608676

    authors: Liu Q,Kim SB,Ahn JH,Hwang BY,Kim SY,Lee MK

    更新日期:2012-01-01 00:00:00

  • A new diacylglycerol from fresh olive pulp.

    abstract::The isolation from olive pulp of a diacylglycerol showing an oleic as well as an elenoic acid residue, the latter probably derived from a natural enzymatic oleuropein hydrolysis, is reported. The given structure is supported by 1H- and 13C-NMR data. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410410001686382

    authors: Marra C,Giordano ME

    更新日期:2005-01-01 00:00:00

  • Isoiridomyrmecin rich essential oil from Nepeta erecta Benth. and its antioxidant activity.

    abstract::The essential oil composition of the aerial parts of Nepeta erecta Benth. (Family: Lamiaceae) from Uttarakhand, India was analysed by capillary gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 34 constituents were identified representing 94.6% of the oil composition. Oxygenated mono...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.531393

    authors: Bisht DS,Joshi SC,Padalia RC,Mathela CS

    更新日期:2012-01-01 00:00:00

  • Effect of meteorological parameters and regions on accumulation pattern of phenolic compounds in different mulberry cultivars grown in China.

    abstract::The compositions of phenolic compounds in 10 cultivars of two mulberry species (Morus atropurpurea Roxb. and Morus alba Linn.) grown in four regions of China were analysed using HPLC-TOF-MS. Results showed that a total of 27 phenolic compounds were identified in these mulberry cultivars. The Taiwan cultivar from the J...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1274895

    authors: Yang J,Zhang X,Jin Q,Gu L,Liu X,Li J,Ni Y

    更新日期:2017-05-01 00:00:00

  • Purification and characterization of two grandiuvarones from Desmos chinensis leaves and their antimicrobial activities.

    abstract::A novel aromatic compound, grandiuvarone B (5-acetoxy-3-benzoyloxymethyl-5H-oxepin-4-one), along with a known compound grandiuvarone A (5-acetoxy-6-benzoyloxymethyl-5H-oxepin-4-one) were isolated from methanol extracts of Desmos chinensis leaves. Their structures were determined by various spectroscopic techniques inc...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1550762

    authors: Zhi QQ,Yan QH,Wang Q,Sun PF,Zhou HY,He ZM

    更新日期:2020-04-01 00:00:00

  • Urinary metabolites of cinobufagin in rats and their antiproliferative activities.

    abstract::Cinobufagin was one of the important cardenolidal steroids and a major component of Chan'Su, a famous traditional Chinese medicine. The urinary metabolites of cinobufagin after single oral doses of 25 mg kg⁻¹ in rats were investigated. Eleven metabolites were isolated and purified by liquid-liquid extraction, open-col...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.510798

    authors: He X,Hu H,Wu Y,Zeng X

    更新日期:2012-01-01 00:00:00

  • 3.5-scFv-β-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive.

    abstract::A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of β-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1860977

    authors: Simonovic M,Mix T,Glumac M,Pejin B

    更新日期:2020-12-18 00:00:00

  • Extraction and partial characterisation of antioxidant pigment produced by Chryseobacterium sp. kr6.

    abstract::Pigments synthesised by Chryseobacterium sp. kr6 growing on feather waste were extracted and characterised. The pigment extract was characterised by KOH test, UV-vis, CIELAB colour system, HPLC-DAD-MS, FTIR and its antioxidant capacity was evaluated. A positive bathochromic shift was observed when kr6 colonies or pigm...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1423304

    authors: Jiménez MEP,Pinilla CMB,Rodrigues E,Brandelli A

    更新日期:2019-06-01 00:00:00

  • Fast analysis of volatile compounds from Lippia citriodora with nanoporous aluminum wire as solid-phase microextraction fibres.

    abstract::In this study, the efficiency of nanoporous aluminium wires as fibres for headspace solid-phase microextraction (HS-SPME) of volatile compounds from Lippia citriodora was investigated and compared with two anodised methods. The prepared fibres are durable with very good chemical and thermal stability which can be coup...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1233407

    authors: Nemati Kharajuo M,Piryaei M,Babashpour Asl M,Abolghasemi MM

    更新日期:2017-02-01 00:00:00

  • A new lupane-type triterpenoid fatty acid ester and other isolates from Ophiorrhiza shendurunii.

    abstract::A new pentacyclic triterpenoid fatty acid ester, lupan-20-ol-3(β)-yl hexadecanoate (1), together with lupan-20-ol-3(β)-yl acetate (2), olean-18-en-3(β)-yl hexadecanoate (3), dotriacontanoic acid (4), stigmasterol (5), rubiadin (6), nonadecanoic acid (7), palmitic acid (8) and camptothecin (9) were isolated from the he...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1160232

    authors: Rajan R,Venkataraman R,Baby S

    更新日期:2016-10-01 00:00:00

  • Senecipyrrolidine, an unusual pyrrolidine alkaloid isolated from Jacobaea gigantea (Desf.) Pelser (Asteraceae).

    abstract::Alkaloids and phenolic compounds are among the most biologically active natural products from the Jacobaea/Senecio genera (Asteraceae). To isolate original natural products directly from Jacobaea gigantea crude polar extracts, centrifugal partition chromatography (CPC) was used. Previously, we reported the phytochemic...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1493584

    authors: Mezache N,Derbré S,Laouer H,Richomme P,Séraphin D,Akkal S

    更新日期:2019-08-01 00:00:00

  • HPLC profiling of phenolics and flavonoids of Adonidia merrillii fruits and their antioxidant and cytotoxic properties.

    abstract::In this study the antioxidant and cytotoxicity activity of the Adonidia merrillii fruits were investigated using different solvent polarities (methanol, ethyl acetate and water). The results showed that the total phenolic and flavonoid contents of the methanolic extract was higher compare with other extract with respe...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1448810

    authors: Vafaei A,Bin Mohamad J,Karimi E

    更新日期:2019-09-01 00:00:00

  • Hypoglycaemic activity of saponin fraction extracted from Momordica charantia in PEG/salt aqueous two-phase systems.

    abstract::Momordica charantia (family, Cucurbitaceae), commonly known as karela or bitter melon (Japanese name 'Tsurureishi'), is used as a folk medicine in China, the Indian subcontinent and South America. In Chinese traditional medicine, the plant is usually used as a hypoglycaemic and anti-diabetic agent. The hypoglycaemic a...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410802079675

    authors: Han C,Hui Q,Wang Y

    更新日期:2008-01-01 00:00:00

  • A new ent-kaurane diterpene from Euphorbia stracheyi Boiss.

    abstract::The chemical investigation of whole plants Euphorbia stracheyi Boiss from China led to the isolation of one new ent-kaurane diterpene, ent-Kaurane-16β,17,19-triol-3-one (1), along with three known ent-kaurane diterpenoids (2-4) as ent-Kaurane-3α,16β,17-triol (2),ent-16S,17-dihydroxy-kaurane-3-one (3) and ent-3S,16S,17...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1222385

    authors: Liu T,Liang Q,Xiong NN,Dai LF,Wang JM,Ji XH,Xu WH

    更新日期:2017-01-01 00:00:00

  • New diterpenoids from Calceolaria polifolia.

    abstract::Four new and seven known diterpenes have been isolated from the dichloromethane extract of the aerial parts of Calceolaria polifolia. The structures of the new compounds were established by spectroscopic evidence. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410500202033

    authors: Garbarino JA,Piovano M,Chamy MC,Espinoza L

    更新日期:2007-02-01 00:00:00

  • Identification of a cDNA clone specific for the taxol synthesis phase of Taxus chinensis cells by mRNA differential display.

    abstract::In order to identify genes related to Taxol biosynthesis, the mRNA differential display method was employed to compare mRNA populations from suspension cultured Taxus chinensis cells before and after beginning to produce Taxol. From a total display of about 4000 PCR products, 104 were derived from cells during the Tax...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410310001630573

    authors: Hu G,Fan T,Mei X

    更新日期:2004-08-01 00:00:00

  • Two new benzoic acid derivatives from endophytic fungus Aspergillus versicolor.

    abstract::Two new benzoic acid derivatives, named methyl(S)-3-hydroxy-4-(2- hydroxy -6-methylheptan-2-yl)benzoate (1) and 2-hydroxy-3-(6- hydroxy-6-methylhept-1-en-2-yl)benzoic acid (2), were isolated from the ethanol extract of an endophytic fungus Aspergillus versicolor derived from the medicinal plant Euphorbia royleana. The...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1777121

    authors: Ye Y,Chen Y,Hou Y,Yu H,Zhu L,Sun Y,Zhou M,Chen Y,Dong M

    更新日期:2020-06-11 00:00:00

  • Abscisic acid identification in Okra, Abelmoschus esculentus L. (Moench): perspective nutraceutical use for the treatment of diabetes.

    abstract::Okra, Abelmoschus esculentus L. (Moench), also known as Lady's Fingers, gombo, or bamje, is an annual plant belonging to the Malvaceae family. Traditional olistic medicine since centuries directly associates this plant and its parts to a beneficial health hypoglycemic effect. Since the abscisic acid (ABA) has been ass...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1637874

    authors: Daliu P,Annunziata G,Tenore GC,Santini A

    更新日期:2020-01-01 00:00:00

  • Two new naphthylisoquinoline alkaloids from stems and leaves of Ancistrocladus tectorius.

    abstract::Two new alkaloids, 4'-O-demethylhamatine (1) and ancistrotectoriline C (2), were isolated from the stems and leaves of Ancistrocladus tectorius. These two compounds represent one 5,1'-coupled and one 7,6'-coupled naphthylisoquinoline alkaloid, respectively. Their structures were elucidated by 1D- and 2D-NMR spectra an...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410902836727

    authors: Tang CP,Xin ZQ,Li XQ,Ye Y

    更新日期:2010-07-01 00:00:00

  • Novel propanamide analogue and antiproliferative diketopiperazines from mangrove Streptomyces sp. Q24.

    abstract::A new propanamide analogue (1), along with one known alkaloid (2) and four known diketopiperazines (3-6), was isolated from a cultured broth of the actinomycete Streptomyces sp. Q24 that was obtained from a sample of mangrove soil. The structures of these isolates were characterised as 3-acetylamino-N-2-thienyl-propan...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1253079

    authors: Ye X,Chai W,Lian XY,Zhang Z

    更新日期:2017-06-01 00:00:00