Anthraquinones from Morinda officinalis roots enhance adipocyte differentiation in 3T3-L1 cells.

Abstract:

:To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining. Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several chromatographic methods led to the isolation of three anthraquinones, 1,2-dimethoxyanthraquinone (1), alizarin-2-methyl ether (2) and rubiadin-1-methyl ether (3). Among them, alizarin-2-methyl ether (2) showed the strongest enhancing activity, followed by rubiadin-1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). At a concentration of 100 µM, alizarin-2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells). Thus, these compounds could be beneficial in the treatment of diabetes.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Liu Q,Kim SB,Ahn JH,Hwang BY,Kim SY,Lee MK

doi

10.1080/14786419.2011.608676

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

1750-4

issue

18

eissn

1478-6419

issn

1478-6427

journal_volume

26

pub_type

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