Abstract:
:Three new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangambin, gugglsterol I, (E)-guggulsterone and (Z)-guggulsterone. Their structures were elucidated on the basis of different spectroscopic data. α-Glucosidase inhibitory effects of HSF and the isolated compounds were evaluated calorimetrically. The HSF showed significant α-glucosidase inhibitory effect [IC(50) value of 140 µg mL(-1) (p < 0.05)]. Under the assay conditions, diasesartemin (IC(50) = 60.6 ± 0.01 µM) was found to be more potent than the positive control, acarbose (IC(50) = 92.94 ± 0.01 µM); a known α-glucosidase inhibitor (p < 0.05). The IC(50) values of epi-mukulin and (Z)-guggulsterone were found to be 159.33 and 132.14 µM, respectively. Other compounds showed weak α-glucosidase inhibitory effects, <30% inhibition of the enzyme activity at 0.1 mg mL(-1).
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
El-Mekkawy S,Meselhy MR,Nkobole N,Lall Ndoi
10.1080/14786419.2012.662651subject
Has Abstractpub_date
2013-01-01 00:00:00pages
146-54issue
2eissn
1478-6419issn
1478-6427journal_volume
27pub_type
杂志文章abstract::Essential oil from Cochlospermum regium (Schrank) Pilg. leaves (CR-EO) has been extracted by hydrodistillation; we analysed the CR-EO by gas chromatography coupled with mass spectrometry. We also conducted histochemical analysis on cross-sections of the central vein of young and adult leaves. A total of 32 compounds w...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.879133
更新日期:2014-01-01 00:00:00
abstract::Phytochemical investigation of chloroform extract from the leaves of the marine plant Posidonia oceanica (L.) Delile (Posidoniaceae), yielded posidozinol, a new methylated sesquiterpene along with β-sitosterol and four known fatty acids: palmitic, palmitoleic, oleic and linoleic acids. The structure elucidation has be...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.725401
更新日期:2013-01-01 00:00:00
abstract::Four C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1484459
更新日期:2019-12-01 00:00:00
abstract::Ten compounds (1-10) were purified from the extract of lichens C. faveomaculata, and among these one new triterpenoid, cryptothecin A (1) was characterized through mass spectrometric and 2D NMR spectroscopic analyses. Some of the isolated compounds were assessed for their antimicrobial (1, 6, and 8) and cytotoxic acti...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1648466
更新日期:2019-08-02 00:00:00
abstract::A phytochemical investigation of the MeOH extract of twigs and leaves of Tephrosia preussi was carried out to give a new kaempferol triglycoside, named tephrokaempferoside (1), together with five known compounds: tephrosin (2), betulinic acid (3), lupeol (4), β-sitosterol (5) and 3-O-β-d-glucopyranoside of β-sitostero...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1315720
更新日期:2017-11-01 00:00:00
abstract::A new resin glycoside, named calysolin XVIII (1), was isolated from the leaves, stems and roots of Calystegia soldanella Roem. et Schult. (Convolvulaceae). The structure of 1 was defined as 11S-jalapinolic acid 11-O-β-d-glucopyranosyl-(1 → 3)-O-(2-O-2S-methylbutyryl,4-O-3-hydroxy-2-methylenebutyryl)-α-l-rhamnopyranosy...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1280492
更新日期:2017-11-01 00:00:00
abstract::A total of 25 compounds including terpenoids, flavonoids, biflavonoids and ginkgolic acids were identified and quantified with a reliable, simple, and simultaneous method from Ginkgo leaves, seed coats and embryoids with different tree ages (approximately identified as 25, 500, 1000 and 2000 years). Leaves had the hig...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1788020
更新日期:2020-07-01 00:00:00
abstract::The present study has been focused on the extraction of natural pigments from tomato industry waste. At first, different solvents and solvents mixture were compared to determine which one is the best for extracting carotenoids compounds from tomato by-products. A mixture of hexane and acetone gave the highest caroteno...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1226828
更新日期:2017-01-01 00:00:00
abstract::Phytochemical investigation on the stem bark of Shorea maxwelliana yielded five oligostilbenoids identified as α-viniferin (1), maximol A (2), vaticanol A (3), suffruticosol A (4) and vaticanol G (5). Chemotaxonomy of isolated compounds was discussed briefly. Major compounds were tested for neurotoxic and cytotoxic ac...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.730047
更新日期:2013-01-01 00:00:00
abstract::A new benzophenone huanglongmycin (HLM) D (1) and two new monomeric xanthones huanglongmycin E (2) and F (3), together with four known aromatic polyketides aloesaponarin II (4) and the previously isolated huanglongmycin A-C (5-7) were obtained from cave-derived Streptomyces sp. CB09001. The structures of 1-3 were esta...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1813134
更新日期:2020-09-01 00:00:00
abstract::Lycopus europaeus L. leaves water extract (LEL) was subjected to phytochemical analysis, and evaluated for its antibacterial and antioxidant effects. Antibacterial activity testing was performed on Staphylococcus aureus clinical strains from catheter-related and skin infections by broth microdilution test. LEL showed ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1010086
更新日期:2015-01-01 00:00:00
abstract::Two new C-15 enolic acyl phragmalin-type limonoid orthoesters, chukvelutilide G (1) and chukrasine F (2), were isolated from the stem barks of Chukrasia tabularis var. velutina. Their structures were elucidated by their extensive high resolution-electrospray ionization mass spectrometry (HR-ESI-MS), one- and two-dimen...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.682995
更新日期:2013-04-01 00:00:00
abstract::First total synthesis of carpatamide-A 7a, cytotoxic arylamine derivative isolated from marine derived Streptomyces sp., was achieved in twelve steps with overall yield of 24% with seven longest linear steps. In the penultimate step, dienoic acid 13 and an amino-phenylpropionic acid methyl ester core 21 were coupled t...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1460837
更新日期:2019-04-01 00:00:00
abstract::Phytochemical investigation of the aerial parts of Eriope blanchetii and E. latifolia (Lamiaceae) yielded podophyllotoxin, as well as the aryltetralin lignans α- and β-peltatin and yatein. Oleanolic, ursolic and epikatonic acids were also isolated. This is the first occurrence of podophyllotoxin in the family. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410902809500
更新日期:2011-09-01 00:00:00
abstract::Seven pentacyclic triterpenoids including 3beta-O-(E)-coumaroyl-15alpha-hydroxy-beta-amyrin (1), 15alpha-hydroxy-beta-amyrin (2), 3beta-taraxerol (3), 3beta-taraxerol formate (4), 3beta-taraxerol acetate (5), 3beta-O-(E)-coumaroyl-taraxerol (6), and 3beta-O-(Z)-coumaroyl-taraxerol (7) were isolated and identified from...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701640452
更新日期:2008-06-15 00:00:00
abstract::The present study was undertaken to investigate the antiproliferative action of isolated M1 (6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) from Mucuna pruriens seeds using human hepatic carcinoma cell line (Huh-7 cells). Initially, docking studies was performed to find out the binding affinities of M...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1020489
更新日期:2016-01-01 00:00:00
abstract::Several factors affect the vegetative growth of fungi, such as temperature, pH, and culture medium. In addition to mycelial growth, these factors affect metabolite production. There are limited studies that have identified the metabolites produced by the fungus Bjerkandera adusta, which have potential biotechnological...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1758092
更新日期:2020-05-06 00:00:00
abstract::In this study, essential oil compositions of two Hypericum L. taxa (Hypericum triquetrifolium Turra. and Hypericum aviculariifolium Jaub. et Spach subsp. depilatum var. depilatum (Freyn et Bornm.) Robson) naturally grown in Turkey were determined using gas chromatography and gas chromatography-mass spectrometry system...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.636743
更新日期:2012-11-01 00:00:00
abstract::Essential oils hydrodistilled from the leaves and stem barks of Goniothalamus macrocalyx Ban., Goniothalamus albiflorus Ban. and Goniothalamus tamirensis Pierre ex Fin. & Gagnep. growing in Vietnam were analysed by gas chromatography (GC) and GC-coupled with mass spectrometry. α-Pinene (1.7-50.0%), β-pinene (tr-6.8%),...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.814051
更新日期:2013-01-01 00:00:00
abstract::The chemical investigation of the extract of the dried leaves of Rauvolfia caffra (Sond) (synonym Rauvolfia macrophylla) (Apocynaceae) led to isolation of a new glycoside derivative, rauvolfianine (1) as well as six known compounds: oleanolic acid (2), sitosterol-3-O-β-D-glucopyranoside (3), betulinic acid (4), vellos...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1356832
更新日期:2018-08-01 00:00:00
abstract::Capparis spinosa L. is a perennial plant typical of the Mediterranean flora and a multipurpose plant used for curing various human ailments. Quaternary ammonium compounds (QACs), as constituents of Capparaceae, play important roles in protecting against abiotic stress. Aim of this work was to determine QACs in root an...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1475376
更新日期:2019-05-01 00:00:00
abstract::GC/FID and GC-MS analysis revealed germacrene D, bicyclogermacrene, α-cadinol and cubenol as major compounds from aril. Germacrene D, bicyclogermacrene, trans-caryophyllene and δ-elemene are major compounds in fruits. Germacrene D, spathulenol, trans-caryophyllene and caryophyllene oxide are major compounds in leaves....
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.987145
更新日期:2015-01-01 00:00:00
abstract::One new neolignan glycoside, dolomiside A (1), together with 11 known phenylpropanoid glycosides were isolated from Dolomiaea souliei (Franch.) Shih. The structures of these isolates were determined by UV, CD, HR-ESI-TOFMS, 1D and 2D NMR analysis. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1552695
更新日期:2020-04-01 00:00:00
abstract::A new isocoumarin, along with 10 known compounds, was isolated from the aerial parts of Aconitum gymnandrum. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Among the known compounds, compound 11 was obtained as a natural product for the first time, which was pre...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1137574
更新日期:2016-08-01 00:00:00
abstract::The antitumour activity of the hydroalcoholic extract of the leaf (PCL) and stem bark (PCB) of Prosopis cineraria (L.) in Swiss albino mice was evaluated against an Ehrlich ascites carcinoma (EAC) tumour model. The activity was assessed using survival time, peritoneal cells, haematological studies, lipid peroxidation,...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.536159
更新日期:2011-04-01 00:00:00
abstract::A new propanamide analogue (1), along with one known alkaloid (2) and four known diketopiperazines (3-6), was isolated from a cultured broth of the actinomycete Streptomyces sp. Q24 that was obtained from a sample of mangrove soil. The structures of these isolates were characterised as 3-acetylamino-N-2-thienyl-propan...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1253079
更新日期:2017-06-01 00:00:00
abstract::The oral squamous cell carcinoma (OSCC) is the eighth more common cancer in men. The development of new and more efficient drugs is needed. Plants of the genus Piper are popularly used in the treatment of many diseases. This study evaluated the antitumor effect of extract, fraction and isolated compounds from leaves o...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1831494
更新日期:2020-10-14 00:00:00
abstract::A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2-14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited ant...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1101107
更新日期:2016-01-01 00:00:00
abstract::The natural product lupeol 1 was isolated from aerial parts of Vernonia scorpioides with satisfactory yield, which made it viable to be used as starting material in semisynthetic approach. Ten lupeol derivatives 2-11 were prepared by classical procedures. Including, five new esters derivatives 7-11, which were obtaine...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1353982
更新日期:2018-02-01 00:00:00
abstract::Two new compounds, myrubol (1) and 3-oxo-11α-hydroxyfriedelane (2), were isolated from the roots of Myrica rubra along with eight known compounds (3-10). Their structures were determined through (1)H-NMR and (13)C-NMR spectral data, including 2-D experiments (HMBC, HMQC, (1)H-(1)H COSY and NOESY) and high-resolution m...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.516749
更新日期:2011-01-01 00:00:00