Evaluation of topical Matricaria chamomilla extract activity on linear incisional wound healing in albino rats.

Abstract:

:In this investigation, the effect of Matricaria chamomilla extract on linear incisional wound healing was studied. Thirty male Wistar rats were subjected to a linear 3 cm incision made over the skin of the back. The animals were randomly divided into three experimental groups, as control, olive oil, and treatment. Control group did not receive any drug or cold cream. Olive oil group received topical olive oil once a day from beginning of experiments to complete wound closure. Treatment group were treated topically by M. chamomilla extract dissolved in olive oil at the same time. For computing the percentage of wound healing, the area of the wound measured at the beginning of experiments and the next 2, 5, 8, 11, 14, 17, and 20 days. The percentage of wound healing was calculated by Walker formula after measurement of the wound area. Results showed that there were statistically significant differences between treatment and olive oil animals (p < 0.05) in most of the days. We conclude that the extract of M. chamomilla administered topically has wound healing potential in linear incisional wound model in rats.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Jarrahi M,Vafaei AA,Taherian AA,Miladi H,Rashidi Pour A

doi

10.1080/14786410701654875

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

697-702

issue

8

eissn

1478-6419

issn

1478-6427

pii

921771465

journal_volume

24

pub_type

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