Abstract:
:The present study was undertaken to investigate the antiproliferative action of isolated M1 (6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) from Mucuna pruriens seeds using human hepatic carcinoma cell line (Huh-7 cells). Initially, docking studies was performed to find out the binding affinities of M1 to caspase-3 and 8 enzymes. Later, cytotoxic action of M1 was measured by cell growth inhibition (MTT), followed by caspase-3 and 8 enzymes assay colorimetrically. Our results collectively suggested that M1 had strong binding affinity to caspase-8 in molecular modelling. M1 possessed antiproliferative activity on Huh-7 cells (EC50 = 13.97 μM) and also inhibited the action of caspase-8 enzyme, signified process of apoptosis. M1 was active against Huh-7 cells that may be useful for future hepatic cancer treatment.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Kumar P,Rawat A,Keshari AK,Singh AK,Maity S,De A,Samanta A,Saha Sdoi
10.1080/14786419.2015.1020489subject
Has Abstractpub_date
2016-01-01 00:00:00pages
460-3issue
4eissn
1478-6419issn
1478-6427journal_volume
30pub_type
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