Abstract:
:A high performance liquid chromatography-time-of-flight-mass spectrometry (HPLC-TOF-MS) method was developed for analysing the chemical constituents in Hedyotis diffusa, which is widely used as a traditional Chinese medicine (TCM) in the field of cancer treatment. The compounds were identified either by comparing the retention time and mass spectrometry data with those of reference compounds or by analysing mass spectrometry data and retrieving reference literature. Among the detected chromatographic peaks, nine components were unambiguously identified, most of which were iridoids. This study is expected to provide an effective and reliable pattern for comprehensive and systematic characterisation of the complex TCM systems.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Wang X,Cheng W,Yao X,Guo Xdoi
10.1080/14786419.2010.537275subject
Has Abstractpub_date
2012-01-01 00:00:00pages
167-72issue
2eissn
1478-6419issn
1478-6427journal_volume
26pub_type
杂志文章abstract::Six compounds, benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate (1), spathulenol (2), 1,7,8-trihydroxy-2-naphtaldehyde (3), quercetin (4), astragalin (5) and 2-methoxy-4-(2-propenyl)phenyl β-D-glucoside (6), were isolated from the leaves of Melia azedarach L. The structure elucidation of compound 1 was discussed in det...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1501690
更新日期:2019-10-01 00:00:00
abstract::Six sesquiterpenoids and four lignans (1-10) were isolated from the n-BuOH extract of the rhizomes of Atractylodes lancea. Among them, the new sesquiterpenoid glycoside named (4 R, 5S, 7R)-hinesolone-11-O-β-ᴅ-glucopyranoside (1), along with three known compounds (2-4) were first obtained from this genus. All the isola...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1553170
更新日期:2020-04-01 00:00:00
abstract::Antibacterial activities of prenylated xanthones from Garcinia mangostana and their synthetic analogues were investigated, and their structure-activity relationships have been studied. γ-Mangostin has shown antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphyl...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.678348
更新日期:2013-01-01 00:00:00
abstract::Four fractions were prepared from the crude extract of Caesalpinia minax Hance and the inhibitory activity of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) was evaluated. The ethyl acetate (EtOAc) fraction showed obvious inhibitory effect. Bioassay-guided fractionation ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1366480
更新日期:2018-04-01 00:00:00
abstract::First total synthesis of carpatamide-A 7a, cytotoxic arylamine derivative isolated from marine derived Streptomyces sp., was achieved in twelve steps with overall yield of 24% with seven longest linear steps. In the penultimate step, dienoic acid 13 and an amino-phenylpropionic acid methyl ester core 21 were coupled t...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1460837
更新日期:2019-04-01 00:00:00
abstract::Alkylglycerols (AKGs) are bioactive natural compounds that vary by alkyl chain length and degree of unsaturation, and their absolute configuration is 2S. Three AKGs (5l-5n) were synthesised in enantiomerically pure form, and were characterised for the first time together with 12 other known and naturally occurring AKG...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1686370
更新日期:2019-11-04 00:00:00
abstract::The composition and antibacterial activity of the essential oil of the aerial flowering parts of Nepeta hormozganica Jamzad have been studied. Analysis of the oil was conducted by GC-FID and GC-MS. Thirty-two components were characterized accounting for 99.4% of the total oil. Oxygenated monoterpenes (87.5%) were foun...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1295237
更新日期:2017-12-01 00:00:00
abstract::Glaucocalyxin A is a natural ent-Kaurane diterpenoid. It has been widely studied for some important biological activities like cytotoxicity and anti-tumour, anti-bacterial, anti-oxidative, anti-coagulative, anti-thrombotic, immune and anti-neuroinflammatory activities. The aim of the present article is to review the a...
journal_title:Natural product research
pub_type: 杂志文章,评审
doi:10.1080/14786419.2014.934235
更新日期:2014-01-01 00:00:00
abstract::A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2-14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited ant...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1101107
更新日期:2016-01-01 00:00:00
abstract::This study investigated the in vitro anticancer potential of phytochemical constituents isolated from the methanolic extract of Eriocephalus africanus. One flavanone (hesperidin) and two flavones (luteolin and apigenin) were isolated for the first time from the plant using column chromatography. Standard MTT assay was...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1744138
更新日期:2020-03-25 00:00:00
abstract::A new chromone glycoside, 8-O-β-D-Glucopyranosyl-2-methylchromone (1), together with eight known compounds (2-9) were isolated from the Tibetan medicine plant of Swertia punicea. All compounds of this plant were reported for the first time. The structures of these metabolites were elucidated by analysis of their HR-ES...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1777123
更新日期:2020-06-11 00:00:00
abstract::Three new aconitine-type C19-diterpenoid alkaloids, taipeinines A-C (1-3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.861832
更新日期:2014-01-01 00:00:00
abstract::A new sesquiterpeniod, 6alpha, 7alpha, 10alpha-trihydroxyisoducane (1), together with two known sesquiterpenoids, oplodiol (2) and oplopanone (3), were isolated from the chloroform extract of the rhizomes of Homalomena occulta. Their structures were elucidated by 1D and 2D NMR spectral interpretation. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802187817
更新日期:2009-01-01 00:00:00
abstract::Two new ditetrahydrofuran lignans, named sieverlignans A and B (1 and 2), together with six known ones (3-8), were isolated from the aerial parts of Artemisia sieversiana. Their structures were established on the basis of spectroscopic analysis including HRMS, NMR spectra and circular dichroism experiments. All the co...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1712384
更新日期:2020-01-13 00:00:00
abstract::Chronic administration of myricetin (100 and 300 mg kg⁻¹, p.o., for 4 weeks) isolated from Vitis vinifera (Vitaceae) ameliorated hypertension and oxidative stress induced by deoxycorticosterone acetate (DOCA)-salt in rats. Myricetin treatment reduced systolic blood pressure, vascular reactivity changes and reversed th...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410903335190
更新日期:2011-09-01 00:00:00
abstract::The chemical composition of three rockrose Cistus species, Cistus monspeliensis, Cistus libanotis and Cistus villosus, collected in Tunisia, was studied by HPTLC, focusing on the terpenes and phenols constituents. Diterpenes of Cistus are important as the main constituents of the leaf sticky aromatic resin, known as l...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.947486
更新日期:2015-02-01 00:00:00
abstract::Chemical investigation of Dendrobium plicatile Lindl resulted in the isolation and identification of one new bibenzyl, 2-chloro-3, 4'-dihydroxy-3',5-dimethoxybibenzyl (1), as well as 15 known stilbenoids. The structures of this new compound was elucidated by extensive spectroscopic analysis, including HRESIMS, 1H and ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1530996
更新日期:2020-02-01 00:00:00
abstract::A novel isoindole alkaloid named oleraisoindole (1), together with six known compounds, 7'-ethoxy-trans-feruloyltyramine (2), N-trans-feruloyltyramine (3), N-trans-feruloyl-3-methoxytyramine (4), N-trans-p-coumaroyltyramine (5) aurantiamide (6) and ferulic acid methyl ester (7) were isolated from Portulaca oleracea L....
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1419226
更新日期:2018-10-01 00:00:00
abstract::A new pterocarpan, named velucarpin D (1), along with nine known pterocarpans (2-10) were isolated from the stems of Dalbergia velutina. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, MCF-7, He...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1749613
更新日期:2020-04-05 00:00:00
abstract::The current study focuses on the chemical composition, and evaluation of antioxidant and antibacterial activity of the aerial parts of Centaurea resupinata subsp. dufourii. Using different chromatographic methods nine compounds 1-9 were isolated. The structural identification of isolated compounds was achieved using s...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1715397
更新日期:2020-01-23 00:00:00
abstract::In order to identify genes related to Taxol biosynthesis, the mRNA differential display method was employed to compare mRNA populations from suspension cultured Taxus chinensis cells before and after beginning to produce Taxol. From a total display of about 4000 PCR products, 104 were derived from cells during the Tax...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410310001630573
更新日期:2004-08-01 00:00:00
abstract::An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type antibiotic, kitamycin C (1), together with ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1295240
更新日期:2017-08-01 00:00:00
abstract::Chemical investigation of the fungus Xylariaceae sp. DPZ-SY43 has led to the isolation of a new compound, xylaolide A (1) together with three known compounds (2-4). The structures were established by analysing the spectroscopic data. Compound 1 was evaluated for its cytotoxicity. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.901318
更新日期:2014-01-01 00:00:00
abstract::In this article, an ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry method was developed to detect the chemical structures of proanthocyanidins (PAs) from seed coats of Schisandra chinensis. The cleavage pathways of the compounds were revealed. The structures of S. chinensis PAs, in...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.950574
更新日期:2014-01-01 00:00:00
abstract::Phytochemical investigations on Phyllanthus emblica have resulted in the isolation of the two new flavonoids, kaempferol-3-O-alpha-L-(6''-methyl)-rhamnopyranoside (1) and kaempferol-3-O-alpha-L-(6''-ethyl)-rhamnopyranoside (2). Their structures were determined on the basis of extensive spectroscopic studies including ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410601124664
更新日期:2007-07-20 00:00:00
abstract::A new benzophenone glycoside, mitraphenone A (1), together with three known compounds (2-4) were isolated from the leaves of the traditionally used medicinal plant Mitracarpus villosus (Rubiaceae) collected in Nigeria. A combination of one- and two-dimensional NMR spectroscopic and mass spectrometric measurements were...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1306701
更新日期:2017-10-01 00:00:00
abstract::Three compounds, toosendanin (1), kulactone (2) and scopoletin (3), were isolated from either the root bark and/or the stem bark of Melia volkensii. Their structures were determined on the basis of spectroscopic data generated and by comparison with data from the literature. 1 and 2, isolated for the first time from M...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1101104
更新日期:2016-09-01 00:00:00
abstract::Phenolic acids, a sub-class of polyphenols, are widely studied. By contrary, 3,4-dihydroxyphenylacetic acid is scarcely studied. For this purpose, a series of 3,4-dihydroxyphenylacetic acid ester and amide derivatives/conjugates were synthesised for the first time. A systematic study has been performed to quantitative...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1342090
更新日期:2018-06-01 00:00:00
abstract::The cytotoxicity of six ent-kaurene diterpenoids isolated from the leaves of Isodon japonica (Burm.f.) Hara var. galaucocalyx (maxin) Hara was evaluated against three human tumour HepG2, GLC-82 and HL-60 cell lines through SRB assay, and their DNA damage potential (against HepG2 cell line) was assessed by comet assay....
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802267734
更新日期:2011-09-01 00:00:00
abstract::The microbial transformation studies of 7-O-prenylquercetin (1), 4'-O-prenylquercetin (2) and quercetin (3) were investigated with 20 different microbial strains to discover new metabolites. It was revealed that the fungus Mucor hiemalis was the most appropriate micro-organism which was capable of transforming these f...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1367780
更新日期:2018-04-01 00:00:00