Velucarpin D, a new pterocarpan from the stems of Dalbergia velutina and its cytotoxicity.

Abstract:

:A new pterocarpan, named velucarpin D (1), along with nine known pterocarpans (2-10) were isolated from the stems of Dalbergia velutina. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, MCF-7, Hep G2, and HT-29). Compound 2 showed potent cytotoxicity against all the five human cancer cell lines with IC50 values in the range of 4.74-8.46 µM. In addition, compounds 1, 3, 4, 5 and 9 showed moderate cytotoxicity against both KB and HeLa S-3 cells with IC50 values in the range of 14.23-29.35 µM.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Kaennakam S,Sukandar ER,Hongnak S,Rassamee K,Siripong P,Tip-Pyang S

doi

10.1080/14786419.2020.1749613

subject

Has Abstract

pub_date

2020-04-05 00:00:00

pages

1-6

eissn

1478-6419

issn

1478-6427

pub_type

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