Abstract:
:A novel monoterpenoid indole alkaloid, melognine (1) possessing an unprecedented skeleton with a 6/6/5/5/6/6 hexatomic rearranged ring system was isolated from the stems of Melodinus fusiformis. The structure with absolute configuration of 1 was established by extensive spectroscopic analyses and quantum ECD calculations. Melognine showed significant cytotoxicity on human breast cancer BT549 cells with an IC50 value of 1.49 μM by MTT assay. Further mechanism of action study indicated that melognine demonstrated the ability to induce apoptosis by activation of caspase-3 and p53, and downregulation of Bcl-2 in BT549 cells.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Zhou J,Du SY,Fang ZY,Feng JHdoi
10.1080/14786419.2019.1682579subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1-7eissn
1478-6419issn
1478-6427pub_type
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