Abstract:
:In this study, a methanolic extract of Betula pendula leaves (BLE) was investigated for its gastroprotective effects against 90% ethanol-induced ulcer in rats. Oral pretreatment of rats with BLE (100, 200 and 400 mg kg(- 1)) significantly reduced the incidence of gastric lesions induced by ethanol administration as compared with misoprostol (0.50 mg kg(- 1)). Furthermore, BLE inhibited the increase in malondialdehyde (MDA) and prevented depletion of total sulhydryl and non-protein sulhydryl groups in rat stomach homogenate when compared with ethanol group. With regard to the effect of lipid peroxidation in vitro, BLE showed the ability to reduce methyl linoleate autoxidation. Chemical characterisation of the main biologically active constituents of BLE was also achieved by means of high-performance liquid chromatography with photodiode array and mass spectrometry detection, showing the presence of myricetin-3-O-galactoside, quercetin glycosides, kaempferol glycosides.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Germanò MP,Cacciola F,Donato P,Dugo P,Certo G,D'Angelo V,Mondello L,Rapisarda Adoi
10.1080/14786419.2012.740036subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1569-75issue
17eissn
1478-6419issn
1478-6427journal_volume
27pub_type
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