Abstract:
:Lycopus europaeus L. leaves water extract (LEL) was subjected to phytochemical analysis, and evaluated for its antibacterial and antioxidant effects. Antibacterial activity testing was performed on Staphylococcus aureus clinical strains from catheter-related and skin infections by broth microdilution test. LEL showed bactericidal activity at concentrations from 2500 to 5000 μg/mL against all, including methicillin resistant and polyresistant nosocomial, strains. Antioxidant activity was examined using DPPH and ABTS (11.3 and 9.8 μg/mL, respectively) and by ferric reducing ability of the plasma method (891 μmol AAE/g dry extract). Phytochemical analysis of LEL was performed by LC-DAD-MS/MS. Ten phenolic compounds were identified; two minor compounds (glucopyranosyl rosmarinic acid and sagerinig acid) have not been described in Lycopus yet. The major compounds, considered to be responsible for biological activities detected in the study, were determined as rosmarinic acid (76 mg/g) and luteolin-7-O-glucuronide (23 mg/g). L. europaeus arises from our study as a promising source of antibacterial agent for topical usage.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Fialová S,Slobodníková L,Veizerová L,Grančai Ddoi
10.1080/14786419.2015.1010086subject
Has Abstractpub_date
2015-01-01 00:00:00pages
2271-4issue
24eissn
1478-6419issn
1478-6427journal_volume
29pub_type
杂志文章abstract::Two saponins: scrokoelziside A (1), scrokoelziside B (2), one iridoid glycoside, eurostoside (3), and two flavonoids: nepitrin (4) and homoplantaginin (5), were isolated from the leaves of Scrophularia ningpoensis for the first time. Moreover, eight known compounds: cane sugar (6), harpagide (7), aucubin (8), 6-O-meth...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802696247
更新日期:2009-01-01 00:00:00
abstract::The importance of the present study is to find out the phytochemical profile of essential oil (EO) of Artemisia tournefortiana Reichb. and its biological evaluation. Nineteen volatile constituents were identified from EO representing 93.47% of total oil composition. Oxygenated monoterpenes (54.46%) were found to be do...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1613990
更新日期:2021-01-01 00:00:00
abstract::One new anthraquinone, 1,8-dihydroxy-2-ethyl-3-methylanthraquinone (1), together with two known compounds octadecanoic acid (2) and cholest-4-en-3-one (3) was isolated from marine actinomycete Streptomyces sp. FX-58. The structure of 1 was elucidated on the basis of spectroscopic methods, especially, the 2D-NMR spectr...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410600899142
更新日期:2006-11-01 00:00:00
abstract::One new iridoid glycoside, 6',10-di-O-(4-hydroxybenzoyl) aucubin (1), together with ten known compounds, including five diterpenoids (2-6), two triterpene glucosides (7-8) and three methoxylated flavonoids (9-11) were isolated from the fruits of Vitex rotundifolia. Compounds (3, 4, 7, and 8) were reported for the firs...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1314284
更新日期:2017-11-01 00:00:00
abstract::A new isoflavonoid, excelsanone (2), was isolated from the ethyl acetate extract of Erythrina excelsa stem bark, together with three known compounds namely 6,8-diprenylgenistein (3), β-sitosterol (1) and sitosteryl-β-D-glucopyranoside (4). Their structures were elucidated using spectroscopic methods (HR-ESI-MS, NMR an...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1495639
更新日期:2020-03-01 00:00:00
abstract::Two new ditetrahydrofuran lignans, named sieverlignans A and B (1 and 2), together with six known ones (3-8), were isolated from the aerial parts of Artemisia sieversiana. Their structures were established on the basis of spectroscopic analysis including HRMS, NMR spectra and circular dichroism experiments. All the co...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1712384
更新日期:2020-01-13 00:00:00
abstract::From the deep-sea-derived fungus Aspergillus candidus, one novel (1) and three known (2-4) p-terphenyl derivates were isolated. The structure of the new compound was established mainly on the basis of extensive analysis of 1D and 2D NMR data. All four isolates were tested for in vitro anti-food allergic and antitumor ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1633651
更新日期:2019-06-24 00:00:00
abstract::α-Mangostin is the major prenylated xanthone from Garcinia mangostana and it has been used also in recent times as starting material for the semisynthetic preparation of various biologically active derivatives. Its structure is characterised by the presence of few functional groups amenable to chemical manipulations, ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.986729
更新日期:2015-01-01 00:00:00
abstract::Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1-3) had been isolated from the culture broth of a marine gut fungus Aspergillus sp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques including mass, NMR and CD spectra together with Marfey's method. Their...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1363752
更新日期:2018-04-01 00:00:00
abstract::In the present study, the chemical composition of the essential oil from the aerial parts of Anthemis secundiramea Biv. subsp. secundiramea L. collected in Sicily was evaluated by GC and gas chromatography-mass spectrometry. The main components of A. secundiramea were (Z)-lyratyl acetate (14.6%), (Z)-chrysanthenyl ace...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1166497
更新日期:2019-04-01 00:00:00
abstract::A new 1,4-phenanthraquinone was isolated from the roots of Menispermum dauricum. The structure was elucidated as 7-hydroxy-3,6-dimethoxy-1,4-phenanthraquinone on the basis of spectral evidence. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410310001620592
更新日期:2004-08-01 00:00:00
abstract::In this computational study, geometric factors are calculated by applying semi-empirical methods (PM3) that support experimental evidence from this lab where bryostatins can bind trivalent iron with six Fe-O bonds forming an octahedral geometry. The geometric factors are calculated for all 20 structures (Fe3+ bound to...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701590087
更新日期:2008-03-20 00:00:00
abstract::In this study, 12 compounds, which include a new flavanone 5-methoxy mundulin, were isolated from the leaves, stem bark and twigs of Mundulea sericea (Willd.) A. Chev. (Fabaceae; Papilionoideae). The structures of the compounds were identified based on spectral data analyses. The constituents of M. sericea also showed...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.616504
更新日期:2012-01-01 00:00:00
abstract::Edible flowers consumption has increased in recent years due to their rich content of healthy phytochemicals. The aim of this study was to analyse the chemical profile of Cucurbita pepo L. flowers, and to explore their antioxidant and hypoglycaemic properties. Moreover, in order to assess in vivo effects, biochemical ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1672067
更新日期:2019-09-30 00:00:00
abstract::In situ generation of hydrogen iodide from cesium iodide/methanesulfonic acid was found to be an attractive reagent combination for the conversion of alkyl, allyl, and benzyl alcohols to their corresponding iodides under mild conditions. The method is compared with that using cesium iodide/p-toluenesulfonic acid or ce...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701766067
更新日期:2008-01-01 00:00:00
abstract::A new dihydroisocoumarin (1) and a new coumarin (2), along with eight known metabolites (3-10), were isolated from the solid substrate fermentation cultures of the fungus Penicillium purpurogenum MHZ 111. Their structures were elucidated by extensive spectroscopic analysis and comparison of their spectroscopic and phy...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1207075
更新日期:2017-03-01 00:00:00
abstract::An HPLC/DAD/ESI-MSn method was established to characterise flavonoids in the seeds of Sophora alopecuroides L. All the flavonoids exhibited abundant [M-H]- ions, which triggered data-dependent multistage mass spectrometry fragmentations. Characteristic UV spectra were used to confirm flavonoid subtypes. In total, 22 f...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.688052
更新日期:2013-03-01 00:00:00
abstract::Chronic neuroinflammation is a key component of many neurodegenerative disorders. Chronic activation of this process produces pro-inflammatory cytokines, prostaglandins and reactive oxygen species that induce brain injury and neuronal dysfunction. Agave species contain saponins, compounds with anti-inflammatory activi...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1608537
更新日期:2019-05-14 00:00:00
abstract::Six new compounds, colletobredins A-D (1-4) and colletomelleins A and B (5 and 6), along with 12 previously identified compounds, were isolated from the culture broth of Colletotrichum aotearoa BCRC 09F0161, a fungal endophyte residing in the leaves of an endemic Formosan plant Bredia oldhamii Hook. f. (Melastomatacea...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1054285
更新日期:2016-01-01 00:00:00
abstract::Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds. Among the compounds isolated, zeylenone (3) showed moderate antitubercular activity against Mycobac...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1741579
更新日期:2020-03-23 00:00:00
abstract::Biotransformation of corosolic acid (1) by Cochliobolus lunatus and Streptomyces asparaginoviolaceus afforded four metabolites, which were identified by using (1)H NMR, (13)C NMR, DEPT, HSQC, HMBC and NOESY spectral data. Biotransformation of corosolic acid by C. lunatus R.R. Nelson & Haasis CGMCC 3.4381 produced thre...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.955485
更新日期:2014-01-01 00:00:00
abstract::Tryptamine derivatives such as tryptamine and bacillamides were strong algicidal compounds promising in controlling harmful algae blooms, but their bioactivity and application researches were hindered by extremely low natural production rates. This study found an induced production of algicidal tryptamine derivatives ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1005619
更新日期:2015-01-01 00:00:00
abstract::The essential oil of Lippia microphylla (LM-OE) presents several pharmacological activities. This work evaluates the tocolytic effect of LM-OE on rats. LM-OE inhibited phasic contractions and relaxed tonic contractions on rat uterus. Considering that nitric oxide (NO) pathway regulates uterine contraction, LM-OE poten...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1614578
更新日期:2019-06-05 00:00:00
abstract::The composition and antibacterial activity of the essential oil of the aerial flowering parts of Nepeta hormozganica Jamzad have been studied. Analysis of the oil was conducted by GC-FID and GC-MS. Thirty-two components were characterized accounting for 99.4% of the total oil. Oxygenated monoterpenes (87.5%) were foun...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1295237
更新日期:2017-12-01 00:00:00
abstract::A new HPLC-DAD method was developed and validated for simultaneous determination of six main phenylethanoid glycosides (calceolarioside D, neocalceolarioside D, verbascoside, isoverbascoside, leucoseptoside A and martynoside) in the aerial parts of four Scutellaria L. taxa from flora of Turkey. All standard compounds ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1486309
更新日期:2019-07-01 00:00:00
abstract::Teucrium marum and T. subspinosum have been extracted with different polarity solvents, each crude extract was analysed with (1)H-NMR to compare the overall metabolic component. The polar extracts showed antioxidant activity in vitro. Verbascoside and arabinosyl-verbascoside were isolated and identified. Their concent...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701571384
更新日期:2007-10-01 00:00:00
abstract::The content of total polyphenols, chlorogenic, caffeic (CaA) and ferulic acids, and rutin, was investigated in plant organs of three introgression lines (IL7-3, IL10-1 and IL12-4) of Solanum pennellii in Solanum lycopersicum cv M82 and compared with that of cropped parental. Such study aims to evidence factors associa...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.704371
更新日期:2013-01-01 00:00:00
abstract::The chemical composition of the essential oil (EO) obtained from the aerial parts of Rydingia michauxii (Briq.) Scheen & V.A. Albert was analysed by gas chromatography and gas chromatography/mass spectrometry (GC/MS). Eighty components were identified in the oil with caryophyllene oxide (20.1%), trans-verbenol (10.2%)...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1343321
更新日期:2018-01-01 00:00:00
abstract::A new citromycetin analogue, ascomycotin A (1), together with eight known compounds, wortmannilactone E (2), orcinol (3), orsellinic acid (4), isosclerone (5), (3R,4S)-( - )-4-hydroxymellein (6), diorcinol (7), chaetocyclinone B (8) and 2,5-dimethoxy-3,6-di(p-methoxypheny1)-1,4-benzoquinone (9), was isolated from the ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.988620
更新日期:2015-01-01 00:00:00
abstract::From the fruiting body of ectomycorrhizal fungi Cortinarius xiphidipus, sterols were identified from the crude extract and the cytotoxic effect of ergosta-4, 6, 8(14), 22-tetraen-3-one (ergone) was evaluated. Ten sterols including ergosta-3,5,7,9(11),22-pentaene, (22E)-ergosta-5,7,9(11),22-tetraen-3b-ol, (3β,22E)-ergo...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1185717
更新日期:2017-02-01 00:00:00