Abstract:
:Three new aconitine-type C19-diterpenoid alkaloids, taipeinines A-C (1-3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (2) and (1α,6α,8α,14α,16α)-20-ethyl-1,8,14-trihydroxy-6,16-dimethoxy-4-(methoxymethyl)-aconitane (3), respectively, on the basis of spectroscopic analyses, mainly MS, 1D and 2D NMR. The cytotoxic activities of these compounds were also assayed, and the results were quite impressive.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Guo ZJ,Xu Y,Zhang H,Li MY,Xi Kdoi
10.1080/14786419.2013.861832subject
Has Abstractpub_date
2014-01-01 00:00:00pages
164-8issue
3eissn
1478-6419issn
1478-6427journal_volume
28pub_type
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