New alkaloids from Aconitum taipaicum and their cytotoxic activities.

Abstract:

:Three new aconitine-type C19-diterpenoid alkaloids, taipeinines A-C (1-3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (2) and (1α,6α,8α,14α,16α)-20-ethyl-1,8,14-trihydroxy-6,16-dimethoxy-4-(methoxymethyl)-aconitane (3), respectively, on the basis of spectroscopic analyses, mainly MS, 1D and 2D NMR. The cytotoxic activities of these compounds were also assayed, and the results were quite impressive.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Guo ZJ,Xu Y,Zhang H,Li MY,Xi K

doi

10.1080/14786419.2013.861832

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

164-8

issue

3

eissn

1478-6419

issn

1478-6427

journal_volume

28

pub_type

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