Abstract:
:Triterpene saponins are throught to be potential anti-tumour agents in many cell types. This study aims to evaluate the cytotoxic activity and mechanism of a triterpene saponin, macranthoside B (MB), isolated from Lonicera macranthoides Hand.-Mazz. (Caprifoliaceae). A cell viability assay showed that MB inhibited cell growth of a panel of six cancer cell lines, especially in human acute promyelocytic leukaemia HL-60 cells, with an IC50 value of 3.8 µmol. A hypodiploid cells assay and an annexin-V-FITC/PI double staining assay showed a significant increase of apoptosis in a dose-dependent manner on HL-60 cells both 24 and 48 h after MB treatment. MB-induced apoptosis was through the caspase-mediated pathway, by activation of caspase-3. Furthermore, a lactate dehydrogenase (LDH) release test suggested that an MB-cholesterol interaction led to the rearrangement of the lipid bilayer and to subsequent cell membrane impairment. Taken together, these findings demonstrate that MB may exhibit cytotoxic activity against HL-60 cells by inducing apoptosis via caspase-dependent pathways and also membrane permeabilisation.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Guan F,Shan Y,Zhao X,Zhang D,Wang M,Peng F,Xia B,Feng Xdoi
10.1080/14786411003752086subject
Has Abstractpub_date
2011-02-01 00:00:00pages
332-40issue
4eissn
1478-6419issn
1478-6427pii
933317990journal_volume
25pub_type
杂志文章abstract::Four fractions were prepared from the crude extract of Caesalpinia minax Hance and the inhibitory activity of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) was evaluated. The ethyl acetate (EtOAc) fraction showed obvious inhibitory effect. Bioassay-guided fractionation ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1366480
更新日期:2018-04-01 00:00:00
abstract::The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1110703
更新日期:2016-07-01 00:00:00
abstract::A new triterpenoid glucoside, leuctriterpencoside (1), along with two known compounds (2-3) were isolated from Leucas zeylanica. The structure of the new compound was elucidated using comprehensive spectroscopic methods. Compound 1 showed significant inhibitory activity against α-glucosidase (IC50 value of 0.85 ± 0.12...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1566820
更新日期:2020-07-01 00:00:00
abstract::Studies were made to increase the yield of piperine extraction using Naviglio Extractor® solid-liquid dynamic extractor (SLDE) from fruits of Piper longum. The effects of ratio w/v were investigated and optimised for the best method. The maximum yield of piperine (317.7 mg/g) from P. longum fruits was obtained in SLDE...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1217209
更新日期:2017-01-01 00:00:00
abstract::Five phenanthrene and two dihydrophenanthrene derivatives were isolated from the diethyl ether extract of fresh rhizomes of Dioscorea communis (L.), among them a phenanthrentriol 1 reported for the first time from Dioscoreaceae family and two dihydrophenanthrene derivatives 6 and 7 reported also for the first time fro...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1468328
更新日期:2019-11-01 00:00:00
abstract::Polyphenol concentrations were quantified by rapid resolution liquid chromatography/mass spectrometry in white table grape. The experimental vineyard was subjected to different kinds of water supply and supply rates. Samples from the same vineyards were also analysed after 6 weeks of storage in a refrigerator and afte...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.606623
更新日期:2012-01-01 00:00:00
abstract::One new havanensin-type limonoid (1) named trisinlin A with two known compounds (4E,8E)-2-[2'-hydroxyhexadecanoyl amino]-4,8-octadecadiene-1,3-diol (2), 9-octadecenoic acid-2',3'-dihydroxypropyl ester (3) were isolated from the roots of Trichilia sinensis. The structure of the new compound was unambiguously determined...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1380016
更新日期:2018-12-01 00:00:00
abstract::In this study, the effects of Benzoinum and Styrax on Escherichia coli (E. coli) growth were investigated by microcalorimetry. Using a TAM Air Isothermal Calorimeter, ampoule method, the power-time curves of E. coli growth at 37°C affected by Benzoinum and Styrax were measured. By analysing some quantitative thermokin...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.533670
更新日期:2011-02-01 00:00:00
abstract::An eremophilane-type sesquiterpenoid (EPS), 3-oxo-eremophila-1,7(11)-dien-12,8β-olide, has been isolated from anti-inflammatory folk herbs, Ligularia pleurocaulis. The aim of present study is to explore protective effects of EPS on lipopolysaccharide (LPS)-induced inflammatory responses in acute lung injury (ALI). EPS...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1736068
更新日期:2020-03-31 00:00:00
abstract::A new oleanane triterpenoid (2) was isolated from the roots of Rubia philippinensis. The structure of 2 was determined by analysis of HRMS and NMR data and identified as a rubiprasin analogue, 16β-hydroxyrubiprasin B. Four related known compounds were also encountered which include rubiprasin B (1), maslinic acid (3),...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1645656
更新日期:2019-07-25 00:00:00
abstract::Pigments synthesised by Chryseobacterium sp. kr6 growing on feather waste were extracted and characterised. The pigment extract was characterised by KOH test, UV-vis, CIELAB colour system, HPLC-DAD-MS, FTIR and its antioxidant capacity was evaluated. A positive bathochromic shift was observed when kr6 colonies or pigm...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1423304
更新日期:2019-06-01 00:00:00
abstract::A new phenylpropanoid allopyranoside (1) and a new indolinone alkaloid (2) were isolated from the rhizomes of Actaea dahurica (syn. Cimicifuga dahurica). The structures of those two compounds were deduced as cimicifugaside F (1) and 3E,11E-(3-methyl-2-butenylidene acid)-2-indolinone-1-O-β-d-glucopyranoside (2) by deta...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1817016
更新日期:2020-09-11 00:00:00
abstract::Phytochemical investigation of the methylenechloride/methanol extract of the aerial parts of Stachys aegyptiaca afforded a new neoclerodane-type diterpene with a new side chain 1, in addition to two known diterpenes 2 and 3 and a known flavonoid glycoside 4. The structures of the compounds were determined by comprehen...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.830217
更新日期:2014-01-01 00:00:00
abstract::A new protostane-type triterpenoid bearing an oxetane ring in the side-chain, named alisol W (1), has been obtained from the dried rhizome of Alisma plantago-aquatica subsp. orientale. The structure and absolute configuration of compound 1 was determined from extensive spectroscopic analysis. In addition, the vasorela...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1519710
更新日期:2019-11-01 00:00:00
abstract::Excessive accumulation of iron in the body can lead to organ injury. Some flavonoids which possess high affinity to iron can be used as iron chelators for curing iron overload diseases such as haemochromatosis. In this article, the effects of baicalin and quercetin on different mouse tissues (liver, kidney and heart) ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.495070
更新日期:2011-07-01 00:00:00
abstract::Lycopus europaeus L. leaves water extract (LEL) was subjected to phytochemical analysis, and evaluated for its antibacterial and antioxidant effects. Antibacterial activity testing was performed on Staphylococcus aureus clinical strains from catheter-related and skin infections by broth microdilution test. LEL showed ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1010086
更新日期:2015-01-01 00:00:00
abstract::Inula graveolens (L.) Desf. is an annual aromatic herb which has various uses on alternative medicine in many region of the world. In this study, antioxidant activities of ethanol and water extracts of the plant leaves were determined by in vitro DPPH method and phenolic composition of the plant sample was determined ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1350673
更新日期:2018-06-01 00:00:00
abstract::A wide range of proteinaceous inhibitors are present in plants to protect themselves from hydrolytic enzymes. In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited α-amylase and α-gluco...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.589386
更新日期:2012-01-01 00:00:00
abstract::The ethanolic extract of the fruits of Momordica dioica was studied for its protective and curative effect against gentamicin-induced acute renal injury in albino rats of both sexes. Gentamicin intoxicated group showed significant increase in blood urea (69.48 +/- 4.34) and serum creatinine (3.017 +/- 0.208) from norm...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802267569
更新日期:2010-09-01 00:00:00
abstract::Two new sphingofungins G (1) and H (2) with a five-membered lactone ring were identified from the solid-state fermentation of Aspergillus penicilliodes Speg., a dominant microorganism isolated previously from the post-fermentation of ripe Pu-er tea, together with six known metabolites. Their structures were elucidated...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1470627
更新日期:2019-05-01 00:00:00
abstract::A new furanodihydrobenzoxanthone, artomandin (1), together with three other flavonoid derivatives, artoindonesianin C, artonol B, and artochamin A, as well as β-sitosterol were isolated from the stem bark of Artocarpus kemando. The structures of these compounds were determined on the basis of spectral evidence. All of...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.534471
更新日期:2011-06-01 00:00:00
abstract::In this study, essential oil compositions of two Hypericum L. taxa (Hypericum triquetrifolium Turra. and Hypericum aviculariifolium Jaub. et Spach subsp. depilatum var. depilatum (Freyn et Bornm.) Robson) naturally grown in Turkey were determined using gas chromatography and gas chromatography-mass spectrometry system...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.636743
更新日期:2012-11-01 00:00:00
abstract::Cardiac glycosides are used for treatment of irregular heartbeats, cardiac arrhythmia and congestive heart failures. In this research, digitoxin as a cardiac glycoside was identified and isolated for the first time in the world from Adonis aestivalis and investigated for its cytotoxic activity against cervical cancer ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1413573
更新日期:2019-03-01 00:00:00
abstract::Present research reports the molecular docking analysis of 2019-nCoV inhibition by antiviral compounds from marine natural resources. For this study, the structure of ligand (antiviral compound) and 2019-nCoV main protease (Mpro) was received from the databases of PubChem and Protein Data Bank (PDB), respectively. Mol...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1791115
更新日期:2020-07-09 00:00:00
abstract::Chemical investigation of the resinous exudates of Commiphora myrrha has led to the isolation of four sesquiterpenes (1a/1b, 2, and 3), including one pair of new sesquiterpene enantiomers (1a/1b), one new racemic mixture 2, and two steroids (4 and 5). Their structures were elucidated by spectroscopic analysis, and the...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1448811
更新日期:2019-02-01 00:00:00
abstract::To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining. Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several ch...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.608676
更新日期:2012-01-01 00:00:00
abstract::Chemical investigation of an ethyl acetate soluble fraction of Sinularia polydactyla (Ehrenberg) led to the isolation of three known terpenoides, two of them sterols, 24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (1), 24-methylcholestane-5-en-3β,25-diol (2), in addition to a cembranoid diterpene, durumolide C ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.805333
更新日期:2013-01-01 00:00:00
abstract::Two new triterpene saponins, namely notoginsenoside Ng5 (1) and notoginsenoside Ng6 (2) were isolated from the leaves of Panax notoginseng, along with five known ones. Their structures were determined by chemical methods, NMR and X-ray experiments. The absolute configuration of compound 3 with four sugar units was con...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1677657
更新日期:2019-10-22 00:00:00
abstract::One new naturally occurring quinone, 3',4'-dihydroxy-1,2,6-trimethoxy-[1,1'-biphenyl]-4(1H)-one (1), one new diarylpropane, emarginone A (2), and one new neolignan, emarginone B (3), along with eighteen known compounds have been isolated from the chemical investigation of the EtOAc-soluble fraction of the Vaccinium em...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1655412
更新日期:2019-09-09 00:00:00
abstract::Six compounds, benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate (1), spathulenol (2), 1,7,8-trihydroxy-2-naphtaldehyde (3), quercetin (4), astragalin (5) and 2-methoxy-4-(2-propenyl)phenyl β-D-glucoside (6), were isolated from the leaves of Melia azedarach L. The structure elucidation of compound 1 was discussed in det...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1501690
更新日期:2019-10-01 00:00:00