Piperidine-mediated synthesis of thiazolyl chalcones and their derivatives as potent antimicrobial agents.

abstract：:Sahandinone (1), 12-deoxysalvipisone (2), miltirone (3), 7α-acetoxyroyleanone (4), and labda-7,14-dien-13-ol (5) were isolated from the roots of Salvia rhytidea Benth. (Lamiaceae). Their structures were elucidated by a combination of spectroscopic analyses including EIMS and NMR. The 13C NMR spectroscopic data were re...

journal_title：Natural product research

authors： Jassbi AR,Eghtesadi F,Hazeri N,Ma'sumi H,Valizadeh J,Chandran JN,Schneider B,Baldwin IT

更新日期：2017-02-01 00:00:00

abstract：:Three new (1-3) and 17 known (4-20) iridoid and secoiridoid glycosides were isolated from a methanol extract of the rhizomes and roots of Gentiana scabra. Their chemical structures were elucidated from 1D and 2D NMR, IR absorption, and HR-ESI-MS spectra, as well as comparisons of these data with reported values. The e...

journal_title：Natural product research

authors： Li W,Zhou W,Kim S,Koo JE,Kim Y,Koh YS,Shim SH,Ma JY,Kim YH

更新日期：2015-01-01 00:00:00

abstract：:An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type antibiotic, kitamycin C (1), together with ...

journal_title：Natural product research

authors： Wang F,Fu SN,Bao YX,Yang Y,Shen HF,Lin BR,Zhou GX

更新日期：2017-08-01 00:00:00

abstract：:Monoterpene glycosides have been isolated from the ethyl acetate soluble fraction of Indigofera hetrantha and their structures assigned to be 3,7-dimethyl-2(E),6-octadien-5-one-1-O-beta-D-6-O-acetylglucopyranoside (1) and 3,7-dimethyl-2(E), 6-octadien-5-one-1-O-[-beta-D-6''-O-acetylglucopyra-nosyl (1'' --> 6')-beta-D-...

journal_title：Natural product research

authors： Mehmood S,Aziz-Ur-Rahman,Ahmad Z,Afza N,Malik A,Ahmad H,Choudhary MI

更新日期：2008-01-01 00:00:00

abstract：:Capparis spinosa L. is a perennial plant typical of the Mediterranean flora and a multipurpose plant used for curing various human ailments. Quaternary ammonium compounds (QACs), as constituents of Capparaceae, play important roles in protecting against abiotic stress. Aim of this work was to determine QACs in root an...

journal_title：Natural product research

authors： Al-Tamimi A,Khatib M,Pieraccini G,Mulinacci N

更新日期：2019-05-01 00:00:00

abstract：:Twenty-one phenolic compounds (1-21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19...

journal_title：Natural product research

authors： Shults EE,Shakirov MM,Pokrovsky MA,Petrova TN,Pokrovsky AG,Gorovoy PG

更新日期：2017-02-01 00:00:00

abstract：:The dichloromethane extracts of the leaves, stem bark, bark and the roots of the three species of the primitive endemic genus Hortonia, H. angustifolia, H. floribunda and H. ovalifolia, collected from nine geographical locations ranging from lower elevations (84-420 m) to higher (2000 m) showed comparable HPLC profile...

journal_title：Natural product research

authors： Ratnayake R,Ratnayake Bandara BM,Wijesundara S,Macleod JK,Simmonds P,Karunaratne V

更新日期：2008-01-01 00:00:00

abstract：:Two alkaloids of the furoquinoline-type were isolated from Ammi majus L.; a new one and was identified as 4-hydro-7-hydroxy-8-methoxyfuroquinoline (1), and the other was isolated for the second time from nature and was identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline (2). The structures of the isolated compoun...

journal_title：Natural product research

authors： Mohammed MM,El-Sharkawy ER

更新日期：2017-03-01 00:00:00

abstract：:A new prenylated xanthone, mangostanaxanthone VIII (7) and six known metabolites: gartanin (1), 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), rubraxanthone (3), 1,3,6,7-tetrahydroxy-8-prenylxanthone (4), garcinone C (5), and xanthone I (9-hydroxycalabaxanthone) (6) were separated...

journal_title：Natural product research

authors： Ibrahim SRM,Abdallah HM,El-Halawany AM,Nafady AM,Mohamed GA

更新日期：2019-01-01 00:00:00

abstract：:Tryptamine derivatives such as tryptamine and bacillamides were strong algicidal compounds promising in controlling harmful algae blooms, but their bioactivity and application researches were hindered by extremely low natural production rates. This study found an induced production of algicidal tryptamine derivatives ...

journal_title：Natural product research

authors： Yu L,Hu Z,Ma Z

更新日期：2015-01-01 00:00:00

abstract：:Two new eremophilanolides, sibiriolides A (1) and B (2), were isolated from the aerial parts of Xanthium sibiricum. The structures of the new compounds were identified as 4S,5R,7R,8R, 11R-2-oxo-1(10)-eremophilen-12,8-olide (1) and 4S,5R,7R,8R,11S-2-oxo-1(10)-eremophilen-12,8-olide (2) by HREIMS and NMR spectroscopic t...

journal_title：Natural product research

authors： Zhang XQ,Ye WC,Jiang RW,Yin ZQ,Zhao SX,Mak TC,Yao XS

更新日期：2006-11-01 00:00:00

abstract：:The chemical investigation of whole plants Piper terminaliflorum Tseng led to the isolation of one new furofuran lignan, 7-methoxyasarinin (1), along with three known amide alkaloids (2-4) as N-3,5-dimethoxy-4-hydroxycinnamoylpyrrole (2), dihydropipercide (3) and 1-[(2E,4E,9E)-10-(3,4-Methylenedioxyphenyl)-2,4,9-undec...

journal_title：Natural product research

authors： Liu T,Liang Q,Zhang XM,Huang SY,Xu WH

更新日期：2018-02-01 00:00:00

abstract：:Terminalia bellerica has been used as a traditional medicine in a variety of ailments including anaemia, asthma, cancer, inflammation, rheumatism and hypertension. In this study, the free radical scavenging and antioxidant activities of methanol extract (ME) and its different solvent fractions (namely hexane (HE), eth...

journal_title：Natural product research

authors： Nampoothiri SV,Binil Raj SS,Prathapan A,Abhilash PA,Arumughan C,Sundaresan A

更新日期：2011-02-01 00:00:00

abstract：:Jatropha mutabilis (Pohl) Baill is an endemic species of the Caatinga biome, little studied in terms of chemical composition. The objective of this work was to develop an analytical methodology to quantify vitexin in the ethanolic extract of J. mutabilis and to evaluate the expectorant and antitussive activities in mi...

journal_title：Natural product research

authors： Costa EC,Menezes PMN,Silva FS,Ribeiro LAA,Rolim LA,Araújo ECDC,Nunes XP

更新日期：2020-10-30 00:00:00

abstract：:A new indole diterpene, named penicindopene A (1), together with seven known compounds (2 - 8), was isolated from the deep-sea fungus Penicillium sp. YPCMAC1. The structure of penicindopene A was elucidated by extensive spectroscopic analyses (1 D and 2 D NMR, and HRESIMS data), in addition to the ECD calculations for...

journal_title：Natural product research

authors： Liu L,Xu W,Li S,Chen M,Cheng Y,Yuan W,Cheng Z,Li Q

更新日期：2019-10-01 00:00:00

abstract：:The methanolic extract of the Tanacetum gracile afforded the isolation of new sesquiterpene lactone, named gracilone (1) along with four known compounds as 14α-taraxeran-3-one (2), 14α-taraxeran-3-ol (3), apigenin (4) and β-sitosterol (5). The structure of compound 1 was elucidated on the basis of 1D, 2D NMR and MS sp...

journal_title：Natural product research

authors： Bhat G,Masood A,Ganai BA,Hamza B,Ganie S,Shafi T,Idris A,Shawl AS,Tantry MA

更新日期：2016-10-01 00:00:00

abstract：:Phytochemical investigation of the methylenechloride/methanol extract of the aerial parts of Stachys aegyptiaca afforded a new neoclerodane-type diterpene with a new side chain 1, in addition to two known diterpenes 2 and 3 and a known flavonoid glycoside 4. The structures of the compounds were determined by comprehen...

journal_title：Natural product research

authors： Mohamed Ael-H,Mohamed NS

更新日期：2014-01-01 00:00:00

abstract：:A new natural diketopiperazine (1) was obtained from the culture broth of Microbispora aerata strain imbas-11A, isolated from penguin excrements collected on the Antarctic Livingston Island. Compound 1 was purified consecutively by solvent extraction, silica gel column chromatography and preparative HPLC. The structur...

journal_title：Natural product research

authors： Ivanova V,Laatsch H,Kolarova M,Aleksieva K

更新日期：2013-01-01 00:00:00

abstract：:A minor new withanolide, named plantagiolide F, was isolated from the whole plant of Tacca plantaginea (Hance). The structure of plantagiolide F was elucidated on the basis of spectroscopic methods including extensive 1- and 2-D NMR experiments. ...

journal_title：Natural product research

authors： Yang JY,Chen CX,Zhao RH,Hao XJ,Liu HY

更新日期：2011-01-01 00:00:00

abstract：:The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), ...

journal_title：Natural product research

authors： Hu X,Sui X,Wang Y,Wang W,Wu H,Zhang F,Tan Y,Zhang F

更新日期：2016-07-01 00:00:00

abstract：:A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside A (1), together with two known megastigmane sesquiterpenoids, citroside A (2) and staphylionoside D (3) were isolated from the leaves of Datura metel L. The structures were determined by analysis of their MS and NMR data as well as by...

journal_title：Natural product research

authors： Guo R,Liu Y,Pan J,Guan W,Yang BY,Kuang HX

更新日期：2019-03-28 00:00:00

abstract：:Although Origanum vulgare (L.) has been deeply analysed at phytochemical level, poor knowledge is available regarding non-volatile compounds such as lipids. The aim of this work was to characterise five wild Sicilian Origanum ecotypes from an agronomic, metabolomic and lipidomic perspective. Serradifalco presented hig...

journal_title：Natural product research

authors： Tuttolomondo T,Martinelli F,Mariotti L,Leto C,Maggio A,La Bella S

更新日期：2016-01-01 00:00:00

abstract：:Chemical investigation of the root bark of Morus alba led to the isolation of a new flavone, dioxycudraflavone A (1) and a new 2-arylbenzofuran, 5-hydroxyethyl moracin M (2), together with seven known compounds namely sanggenon V (3), morusin (4), morusignin L (5), licoflavone C (6), moracin C (7), alfafuran (8) and m...

journal_title：Natural product research

authors： Li M,Wu X,Wang X,Shen T,Ren D

更新日期：2018-01-01 00:00:00

abstract：:Azadirachtin-A (Aza-A, figure 1) was subjected to a variety of synthetic transformations and the antifeedant activity and toxicity of the azadirachtin derivatives were assessed against second instar larvae Spodoptera litura on castor leaves in comparison with the crude material containing 9.14% Aza-A, as well as relat...

journal_title：Natural product research

authors： Deota PT,Upadhyay PR

更新日期：2005-07-01 00:00:00

abstract：:Phytochemical investigation of the twigs of Garcinia nobilis led to the isolation of a new xanthone, named l-hydroxy-2,5-dimethoxyxanthone (1), together with 15 known compounds (2-16). The structures of the new and known compounds were established by means of spectroscopic methods and by comparison with previously rep...

journal_title：Natural product research

authors： Fouotsa H,Tatsimo SJ,Neumann B,Michalek C,Mbazoa CD,Nkengfack AE,Sewald N,Lannang AM

更新日期：2014-01-01 00:00:00

abstract：:New analogues of a long-chain secondary alcohol (1) and laserine (2) were isolated from the flowers of Tamarix hampeana L. The isolated compounds were identified using 1D and 2D NMR, LCMS/APCI, and chemical methods. Laserine was isolated for the first time from T. hampeana L. ...

journal_title：Natural product research

authors： Aykac A,Akgül Y

更新日期：2010-01-01 00:00:00

abstract：:As part of our search for compounds with cytotoxicity from endophytes of traditional Chinese medicines, two novel nor-sesquiterpenoids (1-2) with a new skeleton containing a tetrahydrofuran moiety were isolated form a rice medium of Fusarium tricinctum, an endophytic fungus isolated from the root of Ligusticum chuanxi...

journal_title：Natural product research

authors： Cao YM,Guo DL,Jin MY,Tan L,Yang TL,Deng F,Gu YC,Li XH,Cao ZX,Deng Y

更新日期：2020-01-24 00:00:00

abstract：:This study was designed to characterise the effects of evodiamine on intestinal contractility and reveal the correlated mechanisms. Evodiamine (2.5-80.0 μM) increased normal jejunal contractility and jejunal hypocontractility established under a variety of experimental conditions. Evodiamine-exerted stimulatory effect...

journal_title：Natural product research

authors： Xiong YJ,Chen DP,Peng JY,Wang JY,Lv BC,Liu FF,Lin Y

更新日期：2015-01-01 00:00:00

abstract：:The Stewartia koreana Nakai (SK) had been used in oriental traditional medicine as a remedy for acute gastroenteritis, liver diseases, quadriplegia and pain. The antioxidant activity guided isolation 80% methyl extract from stems of SK yielded eight phenolic compounds. We evaluated the anti-oxidative and anti-inflamma...

journal_title：Natural product research

authors： Kim MH,Jang JH,Oh MH,Heo JH,Lee MW

更新日期：2014-01-01 00:00:00

abstract：:Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1-3) had been isolated from the culture broth of a marine gut fungus Aspergillus sp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques including mass, NMR and CD spectra together with Marfey's method. Their...

journal_title：Natural product research

authors： Xu J,Hu Q,Ding W,Wang P,Di Y

更新日期：2018-04-01 00:00:00