Anticancer effect of Polyphyllin Ι in colorectal cancer cells through ROS-dependent autophagy and G2/M arrest mechanisms.

abstract：:One new xanthone, chryxanthone C (1), together with four known analogues (2-5), were isolated from the cultures of Paecilamyces sp. TE-540, an endophytic fungus obtained from the leaves of Nicotiana tabacum L. The structure of 1 was elucidated by comprehensive spectral analysis including HRESIMS and 1D/2D NMR, which w...

journal_title：Natural product research

authors： Li XQ,Dong QJ,Xu K,Yuan XL,Liu XM,Zhang P

更新日期：2020-10-04 00:00:00

abstract：:Aedes aegypti is a primary vector of dengue, a mosquito-borne viral disease infecting 50-100 million people every year. Here, we biosynthesised mosquitocidal silver nanoparticles (AgNP) using the aqueous leaf extract of Crotalaria verrucosa. The green synthesis of AgNP was studied by UV-vis spectroscopy, SEM, EDX and ...

journal_title：Natural product research

authors： Murugan K,Sanoopa CP,Madhiyazhagan P,Dinesh D,Subramaniam J,Panneerselvam C,Roni M,Suresh U,Nicoletti M,Alarfaj AA,Munusamy MA,Higuchi A,Kumar S,Perumalsamy H,Ahn YJ,Benelli G

更新日期：2016-01-01 00:00:00

abstract：:The Nigerian and South African varieties of Siphonochilus aethiopicus were examined for their phytochemical constituents. The ethyl acetate extract of the rhizomes of the South African variety yielded a novel diarylheptanoid, 2,3-diacetoxy-7-(3'',4''-dihydroxy-5''-methoxyphenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-5-hepte...

journal_title：Natural product research

authors： Igoli NP,Al-Tannak NF,Ezenyi IC,Gray AI,Igoli JO

更新日期：2020-07-27 00:00:00

abstract：:A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside A (1), together with two known megastigmane sesquiterpenoids, citroside A (2) and staphylionoside D (3) were isolated from the leaves of Datura metel L. The structures were determined by analysis of their MS and NMR data as well as by...

journal_title：Natural product research

authors： Guo R,Liu Y,Pan J,Guan W,Yang BY,Kuang HX

更新日期：2019-03-28 00:00:00

abstract：:The anticancer activity of ethanol extract isolated from Goji berry (EEGB) on T47D human breast cancer cell line has been reported. Cell viability and cell proliferation were examined with the use of BrdU, MTT and NR methods. Induction of apoptosis was assessed by propidium iodide and Hoechst 33342 staining. Expressio...

journal_title：Natural product research

authors： Wawruszak A,Czerwonka A,Okła K,Rzeski W

更新日期：2016-09-01 00:00:00

abstract：:Natural products represent a rich source of bioactive compounds that have been historically used to obtain substances with great medicinal potential. The skin of anuran amphibians is a rich source of compounds with a wide range of biological activity. Alzheimer's disease (AD) is a complex disease associated with all k...

journal_title：Natural product research

authors： Spinelli R,Aimaretti FM,López JA,Siano AS

更新日期：2019-03-31 00:00:00

abstract：:The chemical composition of the essential oil (EO) obtained from the aerial parts of Rydingia michauxii (Briq.) Scheen & V.A. Albert was analysed by gas chromatography and gas chromatography/mass spectrometry (GC/MS). Eighty components were identified in the oil with caryophyllene oxide (20.1%), trans-verbenol (10.2%)...

journal_title：Natural product research

authors： Karami A,Esmaeili H,Shahbazian D

更新日期：2018-01-01 00:00:00

abstract：:Cynanchum acutum L. subsp. sibiricum (Willd.) Rech. f. was extracted with hexane, acetone, methanol and water individually. A sample was heated in water then extracted with ethyl acetate. Among the extracts, the ethyl acetate extract exhibited the most antiproliferative activity, so isolation of bioactive compounds wa...

journal_title：Natural product research

authors： Yildiz I,Sen O,Erenler R,Demirtas I,Behcet L

更新日期：2017-11-01 00:00:00

abstract：:A new highly oxygenated germacranolide, carcerlane A (1), together with four known highly oxygenated germacranolides (2-5), was isolated from an ethanol extract of the whole plant of Carpesium nepalense var. lanatum (C.B.Clarke) Kitam. The structures were determined by HRESIMS and extensive analysis of their spectrosc...

journal_title：Natural product research

authors： Yu YF,Li YQ,Wang RY,Liu X,Cui WB,Chen XH,Zhao CM,Qi FM,Zhang ZX,Fei DQ

更新日期：2020-10-22 00:00:00

abstract：:A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of β-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a...

journal_title：Natural product research

authors： Simonovic M,Mix T,Glumac M,Pejin B

更新日期：2020-12-18 00:00:00

abstract：:Two new polyketides, purpurofuranone (1) and purpuropyranone (2), were isolated along with the known polyketides, cillifuranone (3) and taiwapyrone (4), from a mutant BD-3n-1 derived from the diethyl sulfate (DES) mutagenesis of a marine-derived Penicillium purpurogenum G59. The structures of 1 and 2 were elucidated b...

journal_title：Natural product research

authors： Wu CJ,Qiao H,Cui CB,Yang Y,Xu R,Sun CX,Li DH,Li CW

更新日期：2019-10-01 00:00:00

abstract：:Chemical investigation of the stems of Epigunum griffithianum led to the isolation and identification of a new triterpenoid saponin (1) and two known compounds (epigynosides A (2) and B (3)). These structures were elucidated by means of spectroscopic analysis (1D and 2D NMR, MS, UV, IR) as well as comparison with the ...

journal_title：Natural product research

authors： Wang Q,Li WY,Wang YD

更新日期：2020-05-01 00:00:00

abstract：:The chemical composition of the methanol extract obtained from Araucaria cunninghamii Sweet. bark was determined by GC-MS analysis with its antioxidant and antibacterial potential, for the first time. A total of 73 compounds were identified and the extract was strongly characterised by Viridiflorene; Androstan-17-one,...

journal_title：Natural product research

authors： Kumar P,Sati SC,Khulbe K,Pant P,Tripathi AN,Sarvendra K

更新日期：2020-11-29 00:00:00

abstract：:Loliolide content was determined in 13 marine algae including red, brown and green algae collected from the Black Sea, the Dardanelles and the Aegean Sea. Identification and quantification were performed by gas chromatography-mass spectrometry. The loliolide content in green alga is 1.76 microg g(-1), ranges from 0.14...

journal_title：Natural product research

authors： Percot A,Yalcin A,Aysel V,Erduğan H,Dural B,Güven KC

更新日期：2009-01-01 00:00:00

abstract：:Terminalia bellerica has been used as a traditional medicine in a variety of ailments including anaemia, asthma, cancer, inflammation, rheumatism and hypertension. In this study, the free radical scavenging and antioxidant activities of methanol extract (ME) and its different solvent fractions (namely hexane (HE), eth...

journal_title：Natural product research

authors： Nampoothiri SV,Binil Raj SS,Prathapan A,Abhilash PA,Arumughan C,Sundaresan A

更新日期：2011-02-01 00:00:00

abstract：:Eurya acuminata DC and Croton caudatus Gieseler are two ethno-medicinal plants used by Kuki community of North East India. From these plants, we have characterized fifteen phytochemicals (1-15) by extensive use of chromatographic and spectroscopic methods. They were also tested for in vitro cytotoxic effects against A...

journal_title：Natural product research

authors： Neipihoi,Narzary B,Saikia S,Saikia S,Tamuli KJ,Sahoo RK,Dutta D,Bordoloi M

更新日期：2020-09-16 00:00:00

abstract：:Cochliomycin G (1), a new 14-membered resorcylic acid lactone, together with six known analogues (2-7), was isolated from the culture broth of a marine-derived fungus Cochliobolus lunatus. The planar structure of 1 was established by extensive NMR spectroscopy, and the absolute configuration was elucidated by the comb...

journal_title：Natural product research

authors： Xu WF,Xue XJ,Qi YX,Wu NN,Wang CY,Shao CL

更新日期：2021-02-01 00:00:00

abstract：:In order to identify genes related to Taxol biosynthesis, the mRNA differential display method was employed to compare mRNA populations from suspension cultured Taxus chinensis cells before and after beginning to produce Taxol. From a total display of about 4000 PCR products, 104 were derived from cells during the Tax...

journal_title：Natural product research

authors： Hu G,Fan T,Mei X

更新日期：2004-08-01 00:00:00

abstract：:The whole plant, Tricholepis chaetolepis, powder was investigated using proximate and fluorescence analysis along with determining the extractive values. Total phenolics, flavonoids and total protein contents of n-hexane, chloroform and methanolic extracts of the whole plant were also determined. The anti-diabetic act...

journal_title：Natural product research

authors： Abbas A,Hassan SS,Sharif A,Ahmed S

更新日期：2020-02-01 00:00:00

abstract：:The chemical composition and antioxidant activities of the essential oil from Nandina domestica fruits were studied for the first time. Twenty-two compounds, representing 82.79% of the oil, were identified from the oil. The major compounds were 3-hexen-1-ol (12.9%), linalool (12.3%), 2-methoxy-4-vinylphenol (9.9%), ol...

journal_title：Natural product research

authors： Bi SF,Zhu GQ,Wu J,Li ZK,Lv YZ,Fang L

更新日期：2016-01-01 00:00:00

abstract：:A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition. The reaction is highly chemoselective (preferential reaction only on one of the two double bonds present on with...

journal_title：Natural product research

authors： Mandal R,Singh M,Krishnan AAV,Dahat YH,Bharitkar YP,Ravichandiran V,Hazra A

更新日期：2020-08-01 00:00:00

abstract：:The use of natural products as a diet supplement is increasing worldwide but sometimes is not followed by adequate sanitary controls and analyses. Twenty samples of pills and capsules of lyophilised cyanobacteria (blue-green algae), commercialised in Italy as dietary supplements, were found positive at the Vibrio fisc...

journal_title：Natural product research

authors： Bruno M,Fiori M,Mattei D,Melchiorre S,Messineo V,Volpi F,Bogialli S,Nazzari M

更新日期：2006-07-20 00:00:00

abstract：:One new tirucallane-type nortriterpenoid Nortirucallane A (1), together with Chrysoeriol (2) and Isorhamnetin (3), was isolated from the methylene chloride part of Lonicerae japonicae flos. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compound 3 was isolated from the g...

journal_title：Natural product research

authors： Wang X,Zhang J,Li YQ,Du BX,Sun QH,Cao YJ,Jiang HQ,Liu YH,Zhou HL,Rong R

更新日期：2017-10-01 00:00:00

abstract：:The monoterpenoid fractions of three endemic Galium ssp. (Rubiaceae) from Sardinia Island were examined and compared with the iridoidic pattern yet known in Galium species. This comparison evidenced theirs endemic characters. In particular, in G.corsicum and in G. glaucophyllum loganic acid was isolated and identified...

journal_title：Natural product research

authors： Serrilli AM,Ramunno A,Amicucci F,Chicarella V,Santoni S,Ballero M,Serafini M,Bianco A

更新日期：2008-05-10 00:00:00

abstract：:Triterpene saponins in medicinal plants attract scientific attentions for their structural diversity and significant bioactivities. In this work, a high-performance liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF-MS/MS) method is used to rapidly s...

journal_title：Natural product research

authors： Zhang EF,Ling Y,Yin Z,Zhang Q

更新日期：2018-04-01 00:00:00

abstract：:Sanguisorba officinalis L. is a traditional herbal plant that belongs to the genus Sanguisorba and the family Rosaceae. A new ursane-type triterpenoid, 3-oxo-urs-11, 13(18)-dien-19, 28-olide (1), two known ursane-type triterpenoids (3 - 4) and three known oleanane-type triterpenoids (2, 5 - 6) were isolated from the r...

journal_title：Natural product research

authors： Wang R,Sun J,Jin M,Jin L,Qi Y,Cao L,Zhou W,Li G

更新日期：2019-12-04 00:00:00

abstract：:A new 20-membered macrolide named as levantilide C was isolated from the Micromonospora strain FIM07-0019 recovered from shallow coastal waters near the island of Chiloe, Chile. The chemical structure of levantilide C was elucidated on the basis of one- and two-dimensional NMR analysis. Two known indole derivatives we...

journal_title：Natural product research

authors： Fei P,Chuan-Xi W,Yang X,Hong-Lei J,Lu-Jie C,Uribe P,Bull AT,Goodfellow M,Hong J,Yun-Yang L

更新日期：2013-08-01 00:00:00

abstract：:Two new flavonoid glycosides, kaempferol 3-O-α-L-rhamnopyranosyl (1→6) (3''-acetyl)-β-D-galactopyranoside 1 and kaempferol 3-O-α-L-arabinopyranosyl-5-O-α-L-rhamnopyranoside 2, along with six known ones 3-8 were isolated from the flowers of Vicia faba L. (Fabaceae). Methanol extract and the isolated compounds were test...

journal_title：Natural product research

authors： Allam AE,Nafady AM,Nakagawa T,Takemoto N,Shimizu K

更新日期：2018-08-01 00:00:00

abstract：:Oldenlandia umbellata L., commonly known as 'chay root', belongs to the family Rubiaceae and is one of the unexplored dye-yielding plants. The roots from this plant are the sources of red dye. Extraction protocol and dye characterisation have not been completely studied so far in this plant. Hence, in this article we ...

journal_title：Natural product research

authors： Ramamoorthy S,Mudgal G,Rajesh D,Nawaz Khan F,Vijayakumar V,Rajasekaran C

更新日期：2009-01-01 00:00:00

abstract：:A novel butenoate derivative, methyl (Z)-4-{[(Z)-1-(hydroxymethyl)-2-phenyl-1-ethenyl] amino}-4-oxo-2-butenoate (1), was isolated from the fermentation broth of an Aspergillus niger strain Ta1. The structure (1) was elucidated by spectral analysis. Bioassays showed that compound 1 had a weak antioxidant activity. ...

journal_title：Natural product research

authors： Yuan W,Zhu H,Cheng K,Huang Z,Qin Y,Yang J,Zhu P

更新日期：2006-05-20 00:00:00