Semi-synthesis of a novel hybrid isoxazolidino withaferin via chemoselective and diastereoselective 1,3-dipolar nitrone cycloaddition reaction.

abstract：:Monoterpene glycosides have been isolated from the ethyl acetate soluble fraction of Indigofera hetrantha and their structures assigned to be 3,7-dimethyl-2(E),6-octadien-5-one-1-O-beta-D-6-O-acetylglucopyranoside (1) and 3,7-dimethyl-2(E), 6-octadien-5-one-1-O-[-beta-D-6''-O-acetylglucopyra-nosyl (1'' --> 6')-beta-D-...

journal_title：Natural product research

authors： Mehmood S,Aziz-Ur-Rahman,Ahmad Z,Afza N,Malik A,Ahmad H,Choudhary MI

更新日期：2008-01-01 00:00:00

abstract：:One novel hexanordammarane glycoside, ginsenoside R(10), was isolated from the leaves and stems of Panax quinquefolium L. as a minor constituent. It is the first time that a hexanordammarane glycoside isolated from the plant of Panax quinquefolium L. Its structure was elucidated as 3-O-β-D-glucopyranosyl-3β, 12β-dihyd...

journal_title：Natural product research

authors： Liu JP,Lu D,Li PY

更新日期：2012-01-01 00:00:00

abstract：:Three anthraquinones, Cdc25B phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb. (Polygonaceae). Anthraquinones, physcion (1), emodin (2), and questin (3), inhibited the enzymatic activity of Cdc25B phosphatase with IC(50) values of 62.5, 30, and 34 microg mL(...

journal_title：Natural product research

authors： Choi SG,Kim J,Sung ND,Son KH,Cheon HG,Kim KR,Kwon BM

更新日期：2007-05-20 00:00:00

abstract：:In this study, a methanolic extract of Betula pendula leaves (BLE) was investigated for its gastroprotective effects against 90% ethanol-induced ulcer in rats. Oral pretreatment of rats with BLE (100, 200 and 400 mg kg(- 1)) significantly reduced the incidence of gastric lesions induced by ethanol administration as co...

journal_title：Natural product research

authors： Germanò MP,Cacciola F,Donato P,Dugo P,Certo G,D'Angelo V,Mondello L,Rapisarda A

更新日期：2013-01-01 00:00:00

abstract：:The chemical composition and antioxidant activities of the essential oil from Nandina domestica fruits were studied for the first time. Twenty-two compounds, representing 82.79% of the oil, were identified from the oil. The major compounds were 3-hexen-1-ol (12.9%), linalool (12.3%), 2-methoxy-4-vinylphenol (9.9%), ol...

journal_title：Natural product research

authors： Bi SF,Zhu GQ,Wu J,Li ZK,Lv YZ,Fang L

更新日期：2016-01-01 00:00:00

abstract：:This study is designed to examine the chemical composition of the essential oil obtained from Buddleja thyrsoides Lam leaves from south Brazil. Gas chromatography/mass spectrometry analysis resulted in the detection of 12 components, representing 91.4% of the total oil composition. Germacrene D (27.16%), 1,10-di-epi-C...

journal_title：Natural product research

authors： Mahlke JD,Boligon AA,Machado MM,Athayde ML

更新日期：2013-01-01 00:00:00

abstract：:A new triterpene, javablumine A (1) along with six known ones were isolated from the aerial parts of Sambucus javanica Blume. They were identified as 3β,23-dihydroxy-11α,12α-epoxy-urs-20(30)-en-28,13β-olide (1), ursolic acid (2), pomolic acid (3), oleanic acid (4), 2α-hydroxy-oleanolic acid (5), α-amyrin (6), and lupe...

journal_title：Natural product research

authors： Chen F,Liu DL,Wang W,Lv XM,Li W,Shao LD,Wang WJ

更新日期：2020-10-01 00:00:00

abstract：:A minor new withanolide, named plantagiolide F, was isolated from the whole plant of Tacca plantaginea (Hance). The structure of plantagiolide F was elucidated on the basis of spectroscopic methods including extensive 1- and 2-D NMR experiments. ...

journal_title：Natural product research

authors： Yang JY,Chen CX,Zhao RH,Hao XJ,Liu HY

更新日期：2011-01-01 00:00:00

abstract：:The leaves of Alchornea floribunda and Alchornea cordifolia are used traditionally as topical anti-inflammatory agents. In this study, two highly lipophilic fractions AFLF and ACLF isolated from A. floribunda and A. cordifolia leaves respectively were investigated for topical anti-inflammatory effects using xylene-ind...

journal_title：Natural product research

authors： Okoye FB,Osadebe PO,Nworu CS,Okoye NN,Omeje EO,Esimone CO

更新日期：2011-12-01 00:00:00

abstract：:This study aimed at evaluating the impact of environmental factors on the accumulation of various components in Hedera helix L. folium collected from different European countries. The obtained results of studied samples showed that the antioxidant capacities were in the range of 0.027 to 0.688 mg/g. Contents of active...

journal_title：Natural product research

authors： Bezruk I,Materiienko A,Gubar S,Proskurina K,Budanova L,Ivanauskas L,Georgiyants V

更新日期：2020-11-04 00:00:00

abstract：:Stichopus hermanni and Stichopus vastus are sea cucumber species from the Stichopodidae family within the coastal waters of Malaysia. The integument of these invertebrates is hypothesised to contain abundant glycosaminoglycans (GAGs). GAGs are divided into non-sulphated and sulphated GAGs. Sulphated GAGs have various ...

journal_title：Natural product research

authors： Masre SF,Yip GW,Sirajudeen KN,Ghazali FC

更新日期：2012-01-01 00:00:00

abstract：:From the ethanolic extract of Lentinus edodes (Shiitake) eight known sterols were isolated and identified: ergosterol, ergosterol peroxide, (22E)-ergosta-5,7,9(11), 22-tetraen-3beta-ol, (22E)-ergosta-7,9(11),22-trien-3beta-ol, (22E)-ergosta-6,8,22-trien-3beta-ol, (22E)-norergosta-5,7,9,22-tetraen-3beta-ol, 3beta,5alph...

journal_title：Natural product research

authors： Rivera A,Benavides OL,Rios-Motta J

更新日期：2009-01-01 00:00:00

abstract：:A continuous phytochemical study on the seeds of Senna obtusifolia (Syn.: Cassia obtusifolia) led to the isolation of a new anthraquinone analogue, obtusifolin-2-O-β-D-(6'-O-α,β-unsaturated butyryl)-glucopyranoside (1) and a new eurotinone analogue, epi-9-dehydroxyeurotinone-β-D-glucopyranoside (2). Their structures w...

journal_title：Natural product research

authors： Pang X,Wang LM,Zhang YC,Kang LP,Yu HS,Fan GW,Han LF

更新日期：2019-12-01 00:00:00

abstract：:The oral squamous cell carcinoma (OSCC) is the eighth more common cancer in men. The development of new and more efficient drugs is needed. Plants of the genus Piper are popularly used in the treatment of many diseases. This study evaluated the antitumor effect of extract, fraction and isolated compounds from leaves o...

journal_title：Natural product research

authors： Fonseca ACCD,de Queiroz LN,Sales Felisberto J,Jessé Ramos Y,Mesquita Marques A,Wermelinger GF,Pontes B,de Lima Moreira D,Robbs BK

更新日期：2020-10-14 00:00:00

abstract：:Chemical diversity is vital to antitubercular drug discovery as it ensures a novel bioactivity profile. Marine sponges have so far provided more than 1000 new bioactive molecules. Ethyl acetate extract of the marine sponge Dendrilla nigra on bioactivity-guided screening yielded three new compounds denigrins A-C, with ...

journal_title：Natural product research

authors： Murali Krishna Kumar M,Devilal Naik J,Satyavathi K,Ramana H,Raghuveer Varma P,Purna Nagasree K,Smitha D,Venkata Rao D

更新日期：2014-01-01 00:00:00

abstract：:The objective of this work was to produce and characterise nanoemulsions containing tucumã extract and to evaluate the performance of the nanostructure and the free compound regarding antitumor activity, cytotoxicity, and oxidative metabolism in NB4/APL cells. The nanoemulsions showed adequate physicochemical characte...

journal_title：Natural product research

authors： Copetti PM,Gündel SDS,de Oliveira PSB,Favarin FR,Ramos AP,Pintos FG,Pappis L,Gündel A,Machado AK,Ourique AF,Sagrillo MR

更新日期：2020-12-24 00:00:00

abstract：:Spinacia oleracea L. (Spinach) is a leafy vegetable which is considered to have a high nutritional value. Flavonoids in spinach were reported to act as antimutagenic property. Rapid detection of these flavonoids in Spinach was achieved by using HPLC-ESI-QTOF-MS/MS. Thirty six compounds were tentatively identified base...

journal_title：Natural product research

authors： Singh A,Singh P,Kumar B,Kumar S,Dev K,Maurya R

更新日期：2019-08-01 00:00:00

abstract：:Phytochemical investigations on Phyllanthus emblica have resulted in the isolation of the two new flavonoids, kaempferol-3-O-alpha-L-(6''-methyl)-rhamnopyranoside (1) and kaempferol-3-O-alpha-L-(6''-ethyl)-rhamnopyranoside (2). Their structures were determined on the basis of extensive spectroscopic studies including ...

journal_title：Natural product research

authors： Habib-ur-Rehman,Yasin KA,Choudhary MA,Khaliq N,Atta-ur-Rahman,Choudhary MI,Malik S

更新日期：2007-07-20 00:00:00

abstract：:In the context of our previous communication on phytochemical studies of the ethanolic extract of flowers of Alstonia scholaris of Pakistan origin, these have resulted in the isolation of two new triterpenoids. One is of the oleanane type, alstoprenyol, 3-β-hydroxy-28-β-acetoxy-5-olea triterpene (1), the other is of u...

journal_title：Natural product research

authors： Sultana N,Saify ZS,Saleem M,Kamal M

更新日期：2013-01-01 00:00:00

abstract：:The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), ...

journal_title：Natural product research

authors： Hu X,Sui X,Wang Y,Wang W,Wu H,Zhang F,Tan Y,Zhang F

更新日期：2016-07-01 00:00:00

abstract：:Neuroprotection under conditions of oxygen stress of two C21 steroidal glycosides, cynsaccatol Q (1) and saccatol K (2), isolated from Cynanchum auriculatum Royle ex Wight, and their potential mechanisms were studied using the model of H2O2-induced damage on PC12 cells in this paper. Experiments showed that compounds ...

journal_title：Natural product research

authors： Zhang M,Wang D,Li B

更新日期：2019-07-02 00:00:00

abstract：:Penicillium polonicum MCCC3A00951 is a fungus with influenza neuraminidase (NA) inhibition activity derived from a sediment of the mangrove forest of Zhangjiangkou in Fujian province, China. Chemical investigation on an ethyl acetate extract of its fermentation led to the isolation of a new compound, 7-hydroxy-3,10-de...

journal_title：Natural product research

authors： Liu SZ,He FM,Bin YL,Li CF,Xie BY,Tang XX,Qiu YK

更新日期：2020-09-14 00:00:00

abstract：:Tryptamine derivatives such as tryptamine and bacillamides were strong algicidal compounds promising in controlling harmful algae blooms, but their bioactivity and application researches were hindered by extremely low natural production rates. This study found an induced production of algicidal tryptamine derivatives ...

journal_title：Natural product research

authors： Yu L,Hu Z,Ma Z

更新日期：2015-01-01 00:00:00

abstract：:A new chalcone named as balanochalcone (1) together with eight known compounds, methyl caffeate (2), β-hydroxydihydrochalcone (3), methyl gallate (4), dimethyl-6,9,10-trihydroxybenzo[kl]xanthene-1,2-dicarboxylate (5), p-coumaric acid (6), quercetin (7), scopoletin (8) and pinoresinol (9) have been isolated from the et...

journal_title：Natural product research

authors： Quang DN,So TC,Thanh NTP,Hoa LTP,Dien PH,Luong TM,Tung NQ,Long LD,Dai TD,Tien NQ

更新日期：2018-04-01 00:00:00

abstract：:Four xanthones were isolated from Gentianopsis paludosa Ma and were identified by modern spectroscopic methods. Cytotoxicity of the four xanthones was tested on HepG2 cells and HL-60 cells by sulphorhodamine B (SRB) assay. Clonogenic survival assay, trypan blue exclusion method, AO/EB staining and DNA fragmentation as...

journal_title：Natural product research

authors： Ding L,Liu B,Zhang SD,Hou Q,Qi LL,Zhou QY

更新日期：2011-04-01 00:00:00

abstract：:A new bisabolane-type sesquiterpenoid, turmerone Q (1), along with six known compounds (2-7), were isolated from the rhizomes of Curcuma longa L. The structural elucidation of the new compound was conducted using 1H NMR, 13C NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of 1 was elucidat...

journal_title：Natural product research

authors： Yuan T,Zhang C,Qiu C,Xia G,Wang F,Lin B,Li H,Chen L

更新日期：2018-08-01 00:00:00

abstract：:This paper aims to investigate, for the first time, physicochemical characteristics and antioxidant capacity of Psidium myrtoides ripe and unripe fruit. In addition, essential oil was extracted from fresh leaves (PM-EO) collected in dry and rainy seasons to investigate the influence of seasonality and, after that, to ...

journal_title：Natural product research

authors： Dias ALB,Batista HRF,Sousa WC,Bailão EFLC,Rocha JD,Sperandio EM,Fernandes CC,Souchie EL,Miranda MLD

更新日期：2020-11-09 00:00:00

abstract：:The Nigerian and South African varieties of Siphonochilus aethiopicus were examined for their phytochemical constituents. The ethyl acetate extract of the rhizomes of the South African variety yielded a novel diarylheptanoid, 2,3-diacetoxy-7-(3'',4''-dihydroxy-5''-methoxyphenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-5-hepte...

journal_title：Natural product research

authors： Igoli NP,Al-Tannak NF,Ezenyi IC,Gray AI,Igoli JO

更新日期：2020-07-27 00:00:00

abstract：:Glaucocalyxin A is a natural ent-Kaurane diterpenoid. It has been widely studied for some important biological activities like cytotoxicity and anti-tumour, anti-bacterial, anti-oxidative, anti-coagulative, anti-thrombotic, immune and anti-neuroinflammatory activities. The aim of the present article is to review the a...

journal_title：Natural product research

authors： Xiang Z,Wu X,Liu X,Jin Y

更新日期：2014-01-01 00:00:00

abstract：:A new anthraquinone (4) and three known anthraquinones (1-3) were isolated from Galium verum L. Their structures were identified as 1,3-dihydroxy-2-methylanthraquinone (1), physcion (2), 2-hydroxy-1,3-dimethoxyanthraquinone (3), 2,5-dihydroxy-1,3-dimethoxyanthraquinone (4) by means of chemical and spectroscopic analys...

journal_title：Natural product research

authors： Zhao CC,Shao JH,Li X,Xu J,Wang JH

更新日期：2006-09-01 00:00:00