Cochliomycin G, a 14-membered resorcylic acid lactone from a marine-derived fungus Cochliobolus lunatus.

Abstract:

:Cochliomycin G (1), a new 14-membered resorcylic acid lactone, together with six known analogues (2-7), was isolated from the culture broth of a marine-derived fungus Cochliobolus lunatus. The planar structure of 1 was established by extensive NMR spectroscopy, and the absolute configuration was elucidated by the combination of empirical rules, CD data, and 13C chemical shift calculations. Compound 1 exhibited potent antifouling activity against Chlorella vulgaris, Chaetoceros socialis, and Navicula exigua, with EC50 values of 1.09, 0.92, and 0.61 μg/mL, respectively.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Xu WF,Xue XJ,Qi YX,Wu NN,Wang CY,Shao CL

doi

10.1080/14786419.2019.1633646

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

490-493

issue

3

eissn

1478-6419

issn

1478-6427

journal_volume

35

pub_type

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