Abstract:
:Terminalia bellerica has been used as a traditional medicine in a variety of ailments including anaemia, asthma, cancer, inflammation, rheumatism and hypertension. In this study, the free radical scavenging and antioxidant activities of methanol extract (ME) and its different solvent fractions (namely hexane (HE), ethyl acetate (EA), butanol (BL) and water (WA)) of the T. bellerica fruit pericarp were evaluated and compared with standard antioxidant compounds like gallic acid (GA), catechin and ascorbic acid. Among the different fractions tested, the EA fraction exhibited higher antioxidant and radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide and hydroxyl radicals than the other fractions, which may be attributed to its higher phenolic and flavonoid content, since a linear relation was observed between the phenolic content and the antioxidant parameters. The HPTLC analysis of the EA fraction revealed that it mainly contains GA and ferulic acid (FA) as major phenolics, and the higher antioxidant activities of EA fraction may be due to the presence of these compounds.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Nampoothiri SV,Binil Raj SS,Prathapan A,Abhilash PA,Arumughan C,Sundaresan Adoi
10.1080/14786419.2010.482053subject
Has Abstractpub_date
2011-02-01 00:00:00pages
277-87issue
3eissn
1478-6419issn
1478-6427pii
933024671journal_volume
25pub_type
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