Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09.

Abstract:

:An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type antibiotic, kitamycin C (1), together with kitamycin A (2), kitamycin B (3), urauchmycin B (4), deisovaleryblastomycin (5) was isolated from a cultured broth of strain 200-09. The structure of the new compound was determined by spectroscopic data, including HR-ESI-MS and NMR. All the compounds exhibited antifungal activities against Candida albicans with MIC of about 25.0 μg mL-1.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Wang F,Fu SN,Bao YX,Yang Y,Shen HF,Lin BR,Zhou GX

doi

10.1080/14786419.2017.1295240

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

1819-1824

issue

15

eissn

1478-6419

issn

1478-6427

journal_volume

31

pub_type

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