Three new cassane diterpenes from the seeds of Caesalpinia minax Hance.

Abstract:

:Four fractions were prepared from the crude extract of Caesalpinia minax Hance and the inhibitory activity of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) was evaluated. The ethyl acetate (EtOAc) fraction showed obvious inhibitory effect. Bioassay-guided fractionation led to the isolation of three new cassane diterpenes, caesalmin X (1), caesalmin Y (2) and caesalmin Z (3), together with 19 known cassane diterpenoids (4-22). Their structures were mainly characterised on the basis of extensive spectroscopic analyses and comparison with reported data. Moreover, three compounds (20-22) which possessed furanditerpenoid 7,17-lactone structures, displayed moderate activities, with IC50 value of 29.85, 27.38 and 25.40 μM, respectively.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Liu Q,Bai B,Yang DP,Peng SY,Zhu LP,Luo MH,Zhao ZM

doi

10.1080/14786419.2017.1366480

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

885-891

issue

8

eissn

1478-6419

issn

1478-6427

journal_volume

32

pub_type

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