Abstract:
:Four fractions were prepared from the crude extract of Caesalpinia minax Hance and the inhibitory activity of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) was evaluated. The ethyl acetate (EtOAc) fraction showed obvious inhibitory effect. Bioassay-guided fractionation led to the isolation of three new cassane diterpenes, caesalmin X (1), caesalmin Y (2) and caesalmin Z (3), together with 19 known cassane diterpenoids (4-22). Their structures were mainly characterised on the basis of extensive spectroscopic analyses and comparison with reported data. Moreover, three compounds (20-22) which possessed furanditerpenoid 7,17-lactone structures, displayed moderate activities, with IC50 value of 29.85, 27.38 and 25.40 μM, respectively.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Liu Q,Bai B,Yang DP,Peng SY,Zhu LP,Luo MH,Zhao ZMdoi
10.1080/14786419.2017.1366480subject
Has Abstractpub_date
2018-04-01 00:00:00pages
885-891issue
8eissn
1478-6419issn
1478-6427journal_volume
32pub_type
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