Abstract:
:Chemical investigation of an ethyl acetate soluble fraction of Sinularia polydactyla (Ehrenberg) led to the isolation of three known terpenoides, two of them sterols, 24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (1), 24-methylcholestane-5-en-3β,25-diol (2), in addition to a cembranoid diterpene, durumolide C (3), for the first time. The cytotoxicity and antimicrobial activities of the ethyl acetate extract and the isolated compounds 1-3 were evaluated in vitro. Durumolide C (3) showed selective cytotoxicity against HepG2 (IC50 1.0 μg/mL), whereas 24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (1) showed IC50 of 6.1 and 8.2 μg/mL against Hep2 and HCT human cancer cell lines, respectively.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Aboutabl el-SA,Azzam SM,Michel CG,Selim NM,Hegazy MF,Ali AH,Hussein AAdoi
10.1080/14786419.2013.805333subject
Has Abstractpub_date
2013-01-01 00:00:00pages
2224-6issue
23eissn
1478-6419issn
1478-6427journal_volume
27pub_type
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