Abstract:
:First total synthesis of carpatamide-A 7a, cytotoxic arylamine derivative isolated from marine derived Streptomyces sp., was achieved in twelve steps with overall yield of 24% with seven longest linear steps. In the penultimate step, dienoic acid 13 and an amino-phenylpropionic acid methyl ester core 21 were coupled to synthesize methylated derivativative of carpatamide-A 22 followed by demethylation of the intermediate with BBr3 to accomplish carpatamide-A 7a. Both precursors 13 and 21 were synthesized from readily available starting materials i.e. isovaleraldehyde 8 and 2, 4-dihydroxy benzaldehyde 14.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Burman RP,Gupta S,Bhatti J,Verma K,Rajak D,Gill MSdoi
10.1080/14786419.2018.1460837subject
Has Abstractpub_date
2019-04-01 00:00:00pages
1147-1157issue
8eissn
1478-6419issn
1478-6427journal_volume
33pub_type
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