Abstract:
:One new furylhydroquinone derivative (1) and seven known compounds (2-8) were isolated from the roots of Lithospermum erythrorhizon Sieb. et Zucc (Boraginaceae). The structure of 1 was elucidated by extensive spectroscopic methods using NMR and MS. The absolute configuration of shikonofuran J (1) was unambiguously determined by aid of comparison experimental ECD with predicted ECD spectra. All the isolates were tested for their inhibitory activities against IL-6 production in HaCaT cells stimulated by tumor necrosis factor (TNF)-α. It was found that gracicleistanthoside (5) and uridine (7) remarkably down-regulated the TNF-α-induced synthesis of interleukin-6 (IL-6), a pro-inflammatory cytokine associated with cutaneous inflammation, in HaCaT cells.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Ahn J,Chae HS,Chin YW,Kim Jdoi
10.1080/14786419.2018.1431632subject
Has Abstractpub_date
2019-06-01 00:00:00pages
1691-1698issue
12eissn
1478-6419issn
1478-6427journal_volume
33pub_type
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