Abstract:
:Magnolia grandiflora (Magnoliaceae) is an evergreen tree with fragrant and showy flowers native to southeastern USA but widely cultivated all over the world and used in cosmetics industry in treatment of skin diseases. Here, we report on the chemical analysis of the essential oil obtained from flowers of plants cultivated in Iran, together with the evaluation of its antioxidant and cytotoxic activities. The essential oil composition was dominated by bioactive sesquiterpenes, namely β-elemene, bicyclogermacrene, germacrene D and (E)-caryophyllene. The oil exhibited moderate radical scavenging activity towards the [Formula: see text] radical, and mild non-selective inhibitory effects against A375, MDA-MB 231 and T98 G tumour cell lines. The latter were influenced by the presence of the anticancer β-elemene. These results provided new insights for potential application of M. grandiflora volatile oil in the pharmaceutical and cosmetics industry where only the non-volatile magnolol and honokiol have hitherto been fully exploited.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Morshedloo MR,Quassinti L,Bramucci M,Lupidi G,Maggi Fdoi
10.1080/14786419.2017.1303699subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2857-2864issue
24eissn
1478-6419issn
1478-6427journal_volume
31pub_type
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