Abstract:
:The crystal structure and unambiguous absolute configuration of meleagrin (1) isolated from fungus Emericella dentata Nq45 is reported herein to first time on the bases of single crystal X-ray diffraction. Together with 1, haenamindole (2), isorugulosuvine (3), secalonic acid D (4), ergosterol (5) and cerebroside A (6) were obtained and their structures were determined by ESI MS and NMR data analysis. Diverse biological activity of meleagrin (1) was investigated. Compound 1 pronounced potent cytotoxicity against the human cervix carcinoma cell line KB-3-1 and its multidrug resistant sub-clone KB-V1 of IC50 3.07 and 6.07 µM, respectively, in comparison with the reference (+) - griseofulvin (IC50 19, 19.5 µM). Based on the antibiofilm activity, compound 1 displayed as well potent activity against Staphylococcus aureus with an MIC of 0.25 mg/mL. Isolation of the producing fungus and taxonomical characterization is stated as well.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Hamed A,Abdel-Razek AS,Araby M,Abu-Elghait M,El-Hosari DG,Frese M,Soliman HSM,Stammler HG,Sewald N,Shaaban Mdoi
10.1080/14786419.2020.1741583subject
Has Abstractpub_date
2020-03-19 00:00:00pages
1-9eissn
1478-6419issn
1478-6427pub_type
杂志文章abstract::Six compounds, benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate (1), spathulenol (2), 1,7,8-trihydroxy-2-naphtaldehyde (3), quercetin (4), astragalin (5) and 2-methoxy-4-(2-propenyl)phenyl β-D-glucoside (6), were isolated from the leaves of Melia azedarach L. The structure elucidation of compound 1 was discussed in det...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1501690
更新日期:2019-10-01 00:00:00
abstract::Coumarin (2H-1-benzopyran-2-one) is a phenolic compound derived from the shikimate pathway and synthesized by various medicinal and aromatic plants as parent molecule of a large group of secondary metabolites, namely coumarins. Its main utilization is as fixative in perfumes and flavour enhancer. Given its role as phy...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1660334
更新日期:2019-09-11 00:00:00
abstract::A new diterpenoid, 15-epi-(4E)-jatrogrossidentadione acetate, along with several known constituents has been isolated from the stem of Jatropha multifida. The structure of the new compound was settled by a detailed analysis of its 1D- and 2D-NMR spectra. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786411003792207
更新日期:2010-10-01 00:00:00
abstract::Physalins are seco-steroids with a variety of pharmacological activities already described. In this study the pharmacological properties of a standardized concentrated ethanolic extract from Physalis angulata (CEEPA), rich in physalins B, D, F and G, were studied in models of pain and inflammation in mice. Inflammator...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1705812
更新日期:2019-12-24 00:00:00
abstract::Cumin (Cuminum cyminum) is an annual plant from Apiaceae family that is cultivated in Iran as landraces. The most important chemical composition of the cumin essential oil was cuminaldehyde. In this research, the effect of different landraces and growth regulators was evaluated on callus induction, and best callus was...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1272105
更新日期:2017-09-01 00:00:00
abstract::A novel oxime polyketide, maydisone (1), along with two known compounds, 7-hydroxy-2,5-dimethylchromone (2) and 2,5-dimethylbenzoic acid (3) were isolated from the cultures of Bipolaris maydis. Their structures were identified by the application of NMR and MS data analyses and comparison with previous reports. Compoun...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1765339
更新日期:2020-05-13 00:00:00
abstract::Cathepsin B (catB) is a cysteine protease involved in tumour progression and represents a potential therapeutic target in cancer. Among the 15 evaluated extracts from cerrado biome, Myrcia lingua Berg. (Myrtaceae) extract demonstrated to be a source of compounds with potential to inhibit catB. Using bioactivity-guided...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.1002404
更新日期:2015-01-01 00:00:00
abstract::A new flavonoid, dihydroglychalcone-A, was isolated from the leaves extract of Glycosmis chlorosperma in addition to two known sulphur-containing amides, dambullin and gerambullin. The structure of the new compound was assigned as 2'-hydroxy-4,6'-dimethoxy-3',4'-(2",2"-dimethylpyrano)dihydrochalcone. The extract of th...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/1057563031000122121
更新日期:2004-02-01 00:00:00
abstract::A new triterpene, javablumine A (1) along with six known ones were isolated from the aerial parts of Sambucus javanica Blume. They were identified as 3β,23-dihydroxy-11α,12α-epoxy-urs-20(30)-en-28,13β-olide (1), ursolic acid (2), pomolic acid (3), oleanic acid (4), 2α-hydroxy-oleanolic acid (5), α-amyrin (6), and lupe...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1596092
更新日期:2020-10-01 00:00:00
abstract::Plant extracts and products have been used for centuries in traditional medicine; for most of them, in addition to the scant scientific credibility, the chemical composition and spectrum of activity are yet to be explored. To put forward this effort and to identify novel antimicrobial agents, the inhibitory activities...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.529545
更新日期:2011-07-01 00:00:00
abstract::The monoterpenoid fractions of three endemic Galium ssp. (Rubiaceae) from Sardinia Island were examined and compared with the iridoidic pattern yet known in Galium species. This comparison evidenced theirs endemic characters. In particular, in G.corsicum and in G. glaucophyllum loganic acid was isolated and identified...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701614135
更新日期:2008-05-10 00:00:00
abstract::The methanol extract of the root cortex of Paeonia suffruticosa afforded two new monoterpene glycosides, paeoniside A (1) and paeoniside B (2), and three known monoterpene glycosides, paeoniflorin (3), benzoylpaeoniflorin (4) and 4-O-methyl-paeoniflorin (5). Their structures were elucidated on the basis of spectroscop...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.858340
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to explore the extract/fractions and compounds of Diospyros lotus against various Gram-positive and Gram-negative bacteria strain. The results showed marked susceptibility of extract and its fractions against test pathogens. Among them, chloroform fraction was most dominant and effective agai...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1013957
更新日期:2016-01-01 00:00:00
abstract::A new polyoxygenated briarane-type diterpenoid, briarenol A (1), has been isolated from a gorgonian coral belonging to the genus Briareum. The structure, including the relative stereochemistry of briarane 1, was elucidated by the interpretation of spectral data. The configuration of 1 was further supported by molecula...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410512331330611
更新日期:2005-10-01 00:00:00
abstract::The aim of the present study was to evaluate the phenolic contents in capsule and root methanolic extracts of Euphorbia retusa followed by identification of phenolic on capsule extracts through high-performance liquid chromatography (HPLC- DAD) for the first time. Likewise, the antioxidant activity of both extracts wa...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1582040
更新日期:2020-12-01 00:00:00
abstract::Three new sesquiterpenes: 4-acrylic-6-methyl-α-tetralone (1), ainsliaea acid A (2) and ainsliaea acid B (3), together with 8 known compounds (4-11) were isolated from the whole herb of Ainsliaea glabra and their structures were established by means of 1D and 2D NMR spectroscopy and HR-ESIMS. Compounds 1-6 were tested ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1446134
更新日期:2019-01-01 00:00:00
abstract::Meliquercifolins A (1), and B (2), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of Melicope quercifolia along with three known compounds, melicodenines E (3), F (4) and I (5). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D a...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1644634
更新日期:2019-07-22 00:00:00
abstract::The serotonin (5-hydroxytryptamine) type 3 receptor is an important target in the control of digestive dysfunction such as anorexia and bulimia, and 5-HT3 receptor antagonists are effective against eating disorder and the early-phase chemotherapy and radiotherapy evoked vomiting. Our previous research of Valeriana jat...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1662009
更新日期:2019-09-10 00:00:00
abstract::Magnolia grandiflora (Magnoliaceae) is an evergreen tree with fragrant and showy flowers native to southeastern USA but widely cultivated all over the world and used in cosmetics industry in treatment of skin diseases. Here, we report on the chemical analysis of the essential oil obtained from flowers of plants cultiv...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1303699
更新日期:2017-12-01 00:00:00
abstract::Topical sunscreens have been used for many years on exposed areas to protect the skin from the damaging effects of ultraviolets. If the sunscreens were essential, it is suggested that they have adverse effects. We chose to study ferulic acid ethyl ester (FAEE) as agent which could potentially be used in sunscreen prod...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802144974
更新日期:2008-01-01 00:00:00
abstract::The chemical composition of the essential oils isolated from the aerial parts of Anthemis arvensis L. subsp. arvensis, Anthemis cretica subsp. messanensis (Brullo) Giardina & Raimondo and from flowers and leaves of Anthemis cretica subsp. columnae (Ten.) Frezén were determinated by GC-FID and GC-MS analyses. Torreyol ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1297444
更新日期:2017-12-01 00:00:00
abstract::Phytochemical investigation of chloroform extract from the leaves of the marine plant Posidonia oceanica (L.) Delile (Posidoniaceae), yielded posidozinol, a new methylated sesquiterpene along with β-sitosterol and four known fatty acids: palmitic, palmitoleic, oleic and linoleic acids. The structure elucidation has be...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.725401
更新日期:2013-01-01 00:00:00
abstract::The main purpose of this study was the characterisation of 'Serra da Lousã' heather honey by using novel statistical methodology, relevant principal component analysis, in order to assess the correlations between production year, locality and composition. Herein, we also report its chemical composition in terms of sug...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701825004
更新日期:2008-01-01 00:00:00
abstract::Bioassay guided chemical investigation of the gorgonian Pacifigorgia senta led to the discovery of a new 19-oxygenated steroid, cholesta-5,24-diene-3β,7β,19-triol (1), as well as three known steroids (2-4). The structure of 1 was determined by extensive spectroscopic analysis, including NMR and MS spectra. All of the ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1063055
更新日期:2016-06-01 00:00:00
abstract::This study is designed to examine the chemical composition and antioxidant activity of the essential oil of Vitex megapotamica. Gas chromatography-mass spectrometry analysis resulted in the detection of 27 components, representing 92.36% of the total oil composition. The main components in the oil were butylated hydro...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.696258
更新日期:2013-04-01 00:00:00
abstract::Two new briarane-type diterpenoids, dollfusilin A (1) and dollfusilin B (2), along with five known briarane-type diterpenoids (3-7), were isolated from the gorgonian Ellisella dollfusi collected from the South China Sea. The structures of the two new compounds (1 and 2) were elucidated through a comprehensive analysis...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.827191
更新日期:2014-01-01 00:00:00
abstract::A new xanthone, calothorexanthone, together with five known compounds, garbogiol, 1,4,8-trihydroxyxanthone, δ-tocotrienol, 1,7-dihydroxyxanthone and globuxanthone, was isolated from a petroleum ether extract of the bark of Calophyllum thorelii. Their structures were established on the basis of spectroscopic methods, m...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.682992
更新日期:2013-01-01 00:00:00
abstract::In this study, the effects of Benzoinum and Styrax on Escherichia coli (E. coli) growth were investigated by microcalorimetry. Using a TAM Air Isothermal Calorimeter, ampoule method, the power-time curves of E. coli growth at 37°C affected by Benzoinum and Styrax were measured. By analysing some quantitative thermokin...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.533670
更新日期:2011-02-01 00:00:00
abstract::Three new (1-3) and 17 known (4-20) iridoid and secoiridoid glycosides were isolated from a methanol extract of the rhizomes and roots of Gentiana scabra. Their chemical structures were elucidated from 1D and 2D NMR, IR absorption, and HR-ESI-MS spectra, as well as comparisons of these data with reported values. The e...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1013955
更新日期:2015-01-01 00:00:00
abstract::Three biflavonoid glycosides, named carinoside B, C and D (1, 2 and 3, respectively), were isolated from the n-BuOH crude extract of the aerial part of Lomatogonium carinthiacum (Wulfen) Rchb (L. carinthiacum). The structures of 1, 2 and 3 were elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and exten...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1025399
更新日期:2015-01-01 00:00:00