Abstract:
:The aim of this study was to explore the extract/fractions and compounds of Diospyros lotus against various Gram-positive and Gram-negative bacteria strain. The results showed marked susceptibility of extract and its fractions against test pathogens. Among them, chloroform fraction was most dominant and effective against all tested bacteria. The chloroform fraction was subjected to column chromatography which led to the isolation of lupeol (1), 7-methyljuglone (2), β-sitosterol (3), stigmasterol (4), betulinic acid (5), diospyrin (6) and 8-hydroxyisodiospyrin (7). Among the isolated compounds, betulinic acid (5) showed significant activity against most of the tested pathogen. In conclusion, our study validated the traditional uses of the plant in the treatment of infectious diseases which was also strongly supported by the isolated compound, betulinic acid (5).
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Rauf A,Uddin G,Khan H,Arfan M,Siddiqui BSdoi
10.1080/14786419.2015.1013957subject
Has Abstractpub_date
2016-01-01 00:00:00pages
426-8issue
4eissn
1478-6419issn
1478-6427journal_volume
30pub_type
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