Abstract:
:A new cytisine-type alkaloid, along with five known alkaloids was obtained from the seeds of Sophora alopecuroides. Their structures were determined to be (-)-N-(2'-hydroxy-3',5'-di-tert-butyl-toluene)-cytisine (1), (-)-lupanine (2), (+)-matrine (3), (+)-sophoramine (4), (+)-lehmannine (5) and (-)-sophocarpine (6). Their structures were established by NMR, ECD and HRESIMS data analyses. Their cytotoxicity effects against five human tumor cell lines were tested by MTT assay. Compound 1 has showed a wide range of cytotoxicity activities against varied tumor cells in vitro.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Rong ZJ,Gao XX,Hu GS,Yan T,Jia JM,Wang AHdoi
10.1080/14786419.2020.1824226subject
Has Abstractpub_date
2020-09-23 00:00:00pages
1-6eissn
1478-6419issn
1478-6427pub_type
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