Undescribed benzophenone and xanthones from cave-derived Streptomyces sp. CB09001.

Abstract:

:A new benzophenone huanglongmycin (HLM) D (1) and two new monomeric xanthones huanglongmycin E (2) and F (3), together with four known aromatic polyketides aloesaponarin II (4) and the previously isolated huanglongmycin A-C (5-7) were obtained from cave-derived Streptomyces sp. CB09001. The structures of 1-3 were established based on 1D, 2D NMR and HRMS data. Compounds 1-7 may be biosynthesized by a type II huanglongmycin polyketide synthase based on gene inactivation of hlmG encoding KSɑ in hlm gene cluster and their plausible biosynthetic mechanism was proposed.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Jiang L,Xiang J,Zhu S,Tang D,Gong B,Pu H,Duan Y,Huang Y

doi

10.1080/14786419.2020.1813134

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1-9

eissn

1478-6419

issn

1478-6427

pub_type

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