Abstract:
:The antiplasmodial active extract of Xanthium cavanillesii contains 3,4-dicaffeoyl quinic acid (3,4-DCQA), 3,5-dicaffeoyl quinic acid (3,5-DCQA) and 1,3,5-tricaffeoyl quinic acid (1,3,5-TCQA). These results inspired us to investigate the interaction of these molecules with a promising validated target of Plasmodium, PfATP6 orthologue of mammalian Ca+2-ATPase. Models of this receptor were obtained through comparative modelling. Afterwards, molecular docking studies were used to identify possible interaction modes of these caffeoyl quinic derivatives on the binding site. The 1,3,5-TCQA had the best energy, but all of these had better energy than thapsigargin, a non-competitive inhibitor of the sarco/endoplasmatic reticulum Ca+2-ATPase (SERCA).
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Taranto AG,Costa SC,Leite FH,de Sá MS,Soares MB,Mussi MM,Branco Adoi
10.1080/14786419.2016.1219856subject
Has Abstractpub_date
2017-03-01 00:00:00pages
729-733issue
6eissn
1478-6419issn
1478-6427journal_volume
31pub_type
杂志文章abstract::Thirteen phenones were obtained from the 70% ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. Among them, compound 1 was identified as a new compound, and compounds 5 and 13 were obtained from genus Paeonia for the first time. The inh...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1230114
更新日期:2017-02-01 00:00:00
abstract::A new pentacyclic triterpenoid fatty acid ester, lupan-20-ol-3(β)-yl hexadecanoate (1), together with lupan-20-ol-3(β)-yl acetate (2), olean-18-en-3(β)-yl hexadecanoate (3), dotriacontanoic acid (4), stigmasterol (5), rubiadin (6), nonadecanoic acid (7), palmitic acid (8) and camptothecin (9) were isolated from the he...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1160232
更新日期:2016-10-01 00:00:00
abstract::Chemical diversity is vital to antitubercular drug discovery as it ensures a novel bioactivity profile. Marine sponges have so far provided more than 1000 new bioactive molecules. Ethyl acetate extract of the marine sponge Dendrilla nigra on bioactivity-guided screening yielded three new compounds denigrins A-C, with ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.891112
更新日期:2014-01-01 00:00:00
abstract::The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1110703
更新日期:2016-07-01 00:00:00
abstract::Fuzhuan brick-tea (FBT) is unique for a fungal fermentation stage in its manufacture process and is classified in dark tea. A new acylated flavonol glycoside, kaempferol 3-O-[E-p-coumaroyl-(→2)][α-l-arabinopyranosyl-(1→3)][α-l-rhamnopyranosyl(1→6)]-β-d-glucopyranoside, which was trivially named as camellikaempferoside...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1136911
更新日期:2016-12-01 00:00:00
abstract::Chemical investigation of an ethyl acetate soluble fraction of Sinularia polydactyla (Ehrenberg) led to the isolation of three known terpenoides, two of them sterols, 24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (1), 24-methylcholestane-5-en-3β,25-diol (2), in addition to a cembranoid diterpene, durumolide C ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.805333
更新日期:2013-01-01 00:00:00
abstract::Thirty semicarbazone and thiosemicarbazone derivatives (2a-w and 4a-g) from chalcones containing furan and thiophene ring were designed and synthesized. They were characterized by IR, 1H NMR, 13C NMR and HRMS. The crystal structure of compound 2r was characterized by single crystal X-ray diffraction. It crystallizes i...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1739679
更新日期:2020-03-16 00:00:00
abstract::Designing propolis products for external use involves determining the optimal form of propolis for the introduction into dermatological pharmaceuticals and cosmetic preparations. As a potent ingredient, propolis oil extract from raw material harvested in Lithuania was analysed. The rheological characteristics, content...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.529440
更新日期:2011-09-01 00:00:00
abstract::Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were ac...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1434637
更新日期:2019-06-01 00:00:00
abstract::Phytochemical investigation of the twigs of Garcinia nobilis led to the isolation of a new xanthone, named l-hydroxy-2,5-dimethoxyxanthone (1), together with 15 known compounds (2-16). The structures of the new and known compounds were established by means of spectroscopic methods and by comparison with previously rep...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.903398
更新日期:2014-01-01 00:00:00
abstract::Two new xanthone derivatives, penixanthones A (1) and B (2), together with three known compounds, aspenicillide (3), 1,5-dihydroxy-3-methoxy-7-methyl-anthracene-9,10-dione (4) and 1,2-indandiol (5), were isolated from the ethyl acetate extract of a culture of the fungus Penicillium sp. SYFz-1, which was separated from...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1297442
更新日期:2017-10-01 00:00:00
abstract::One new 14-membered ring cyclopeptide alkaloid, plenane A (1), along with six known compounds (2-7), was isolated from the roots of Clematis florida. Their structures were elucidated by means of NMR spectroscopic analysis and mass spectrometry. In addition, their anti- inflammatory effects on lipopolysaccharide-induce...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1809399
更新日期:2020-08-18 00:00:00
abstract::Two new 19-hydroxy bufadienolides, named bufohydrolide A (1) and bufohydrolide B (2), and four known analogs (3-6) were isolated from the aqueous extracts of the skins of Bufo melanosticus. Their structures were established by spectral data analyses, such as UV, IR, 1 D/2D NMR and mass spectra. Compounds 1-6 were eval...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1741582
更新日期:2020-03-23 00:00:00
abstract::One new flavonoid, 5,7,8,4'-tetrahydroxy-3-methoxyflavone-8-O-β-d-xylopyranoside (2), along with other four known flavones (1, 3-5) were isolated from the aerial parts of Solanum rostratum. 8-hydroxyflavonoid was isolated from series Androceras for the first time. The structure of the new compound 2 was determined on ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1290621
更新日期:2017-08-01 00:00:00
abstract::Globe artichoke has been long considered a nutraceutical food for its valuable content of bioactive compounds. However, beside a well-known polyphenol profile, poor information is available about its metabolite and mineral composition. The aim of this study was to investigate edible parts of Sicilian artichokes, 'Spin...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1258563
更新日期:2017-05-01 00:00:00
abstract::A new carotenoid glycoside, namely neo-rehmannioside (1), together with five known compounds, 6-O-seco-hydroxyaeginetoyl ajugol (2), oxyrehmaionoside B (3), ajugol (4), geniposidic acid (5) and geniposide (6) was isolated from the 95% ethanol extract of dry roots of Rehmannia glutinosa. The structure of the new compou...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.514268
更新日期:2011-08-01 00:00:00
abstract::A simple and efficient method was developed for simultaneous analysis of five illegal residual β2-agonists in cattle hair. β2-Agonists were quantified by ultra high performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry operating in positive multiple-reaction monitoring mode. T...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1190718
更新日期:2017-02-01 00:00:00
abstract::New sesquiterpene glycoside, cyclodipeptide and piperidine derivative were isolated from Streptomyces sp. YIM 63342. On the basis of spectral data, their structures were determined as 3R, 5R, 6S, 7E, 9R-megastigman-7-en-3,5,6,9-tetrol-9-O-β-D-apiofuranosyl-(1→ 2)-β-D-glucopyranoside (1), cyclo (L-Pro-L-OMet) (2) and (...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.718776
更新日期:2013-01-01 00:00:00
abstract::Medicinal plants have been the main remedy to treat various ailments for a long time and nowadays, many drugs have been developed from traditional medicine. This paper reviews some medicinal plants and their main constituents which possess anti-inflammatory activities useful for curing joint inflammation, inflammatory...
journal_title:Natural product research
pub_type: 杂志文章,评审
doi:10.1080/14786419.2015.1062761
更新日期:2016-06-01 00:00:00
abstract::Two new iridoids namely valerialloside A and valerianoside A (1 and 2) along with five known compounds (3-7) were isolated from the roots of Valeriana jatamansi Jones. The structure of new compounds were determined using 1D and 2D NMR including 1H-1H COSY, HSQC, HMBC and NOESY spectroscopic techniques. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1858412
更新日期:2020-12-09 00:00:00
abstract::A series of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine (7-12) have been synthesised by reduction of 3-alkyl-2,6-diarylpiperidin-4-one using the Grignard reagent. Structural assignments and conformational analysis of the compounds were established based on the spectral studies. All the piperdin-4-ol derivatives (7-12)...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.671317
更新日期:2013-01-01 00:00:00
abstract::Phytochemical investigations on Phyllanthus emblica have resulted in the isolation of the two new flavonoids, kaempferol-3-O-alpha-L-(6''-methyl)-rhamnopyranoside (1) and kaempferol-3-O-alpha-L-(6''-ethyl)-rhamnopyranoside (2). Their structures were determined on the basis of extensive spectroscopic studies including ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410601124664
更新日期:2007-07-20 00:00:00
abstract::Topical sunscreens have been used for many years on exposed areas to protect the skin from the damaging effects of ultraviolets. If the sunscreens were essential, it is suggested that they have adverse effects. We chose to study ferulic acid ethyl ester (FAEE) as agent which could potentially be used in sunscreen prod...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802144974
更新日期:2008-01-01 00:00:00
abstract::Plant extracts and products have been used for centuries in traditional medicine; for most of them, in addition to the scant scientific credibility, the chemical composition and spectrum of activity are yet to be explored. To put forward this effort and to identify novel antimicrobial agents, the inhibitory activities...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.529545
更新日期:2011-07-01 00:00:00
abstract::Crambe orientalis L. (Brassicaceae), a perennial herb, is indigenous to Iran. The essential oils of flowering tops and leaves of the plant were evaluated by GC-MS. Our results showed that while 2-methyl-5-hexenitrile (19.5%) and benzyl cyanide (16.9%) were the major components of flowering tops oil, the oil of the lea...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802611303
更新日期:2009-01-01 00:00:00
abstract::A new natural diketopiperazine (1) was obtained from the culture broth of Microbispora aerata strain imbas-11A, isolated from penguin excrements collected on the Antarctic Livingston Island. Compound 1 was purified consecutively by solvent extraction, silica gel column chromatography and preparative HPLC. The structur...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.665911
更新日期:2013-01-01 00:00:00
abstract::Alternanthera brasiliana is popularly known as 'penicillin' and used as an anti-inflammatory and for wound healing. The objective of this work was the phytochemical study of the species by analytical techniques such as LC-MS/MS and GC-MS. Twenty-seven compounds were identified, five by LC-MS and 22 by GC-MS analysis. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1533827
更新日期:2020-02-01 00:00:00
abstract::Chromatographic fractionation of the chloroform extracts from the stem bark and stems of Guettarda grazielae resulted in the isolation of a new iridoid (guettardodiol, 1) and the secoiridoid sarracenin (2), described for the first time in this genus. The structural elucidation of these compounds was based on spectrosc...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.507547
更新日期:2011-10-01 00:00:00
abstract::The structure of pregnane oligoglycosides, namely rocinine (1) and marsdinine (11), which have been isolated from the chloroform soluble extract of the dried stem of Marsdenia roylei, were elucidated using MS, (1)H NMR, (13)C NMR, (1)H-(1)H COSY, HSQC and TOCSY experiments as well as chemical degradation and derivatis...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410902940933
更新日期:2009-01-01 00:00:00
abstract::Two new flavonol glycosides, isorhamnetin 3-O-β-glucopyranoside-4'-O-β-xylopyranoside (1) and kaempferol 3-O-β-glucopyranoside -4'-O-β-xylopyranoside (2), were isolated from the defatted aqueous methanol extract of the whole plant Diplotaxis harra along with 12 known flavonols (3-14). They were characterised by chemic...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.825914
更新日期:2013-01-01 00:00:00