Abstract:
:Eight known abietane diterpenes (1-8) were isolated for the first time from Abies numidica cones (Pinaceae). The structures of all compounds were established by means of 1D and 2D NMR, and UV spectral analyses. The hydromethanolic extract of A. numidica cones was tested for its antimicrobial activity against 17 gram-positive and gram-negative bacteria and against five yeasts by the use of liquid and solid medium and bioautography methods. The best antimicrobial activity was found against gram-positive bacteria (MIC ≤ 0.3 mg/mL) Bacillus subtilis, Enterococcus faecalis ATCC 1034, Staphylococcus aureus 8325.4, S. aureus CIP 53.154, Micrococcus luteus and Listeria innocua and against Candida yeasts. The determination of MIC's of isolated products showed a high activity of compounds 4 and 6 against S. aureus, L. innocua (MIC = 62.5 μg/mL) and E. faecalis (MIC = 125 μg/mL).
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Belhadj Mostefa M,Abedini A,Voutquenne-Nazabadioko L,Gangloff SC,Kabouche A,Kabouche Zdoi
10.1080/14786419.2016.1190723subject
Has Abstractpub_date
2017-03-01 00:00:00pages
568-571issue
5eissn
1478-6419issn
1478-6427journal_volume
31pub_type
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