Effect of Agave americana L. on the human, and Aspergillus oryzae S2 α-amylase inhibitions.

Abstract:

:Among phenolic compounds, Agave americana L. extract contained puerarin (38.4%) and p-coumaric acid (12.29%) (pCa). From the Lineweaver-Burk plots, pCa and puerarin demonstrated a competitive and a non competitive inhibitions towards human α-amylase activity, respectively. PCa exhibited a higher human inhibitory activity with an IC50 of 98.8 μM which was about 2.3 times than acarbose. Puerarin (IC50 = 3.87 μM) and pCa (IC50 = 10.16 μM) also showed an excellent inhibition for Aspergillus oryzae S2 α-amylase activity. The inhibitions of the described biocatalysts compounds towards both amylases were significantly decreased when they were pre-incubated with starch. The binding modes of these compounds were evaluated in silico. The binding efficiency order of these molecules in terms of polar contact numbers for both enzymes was in agreement with the in vitro studies. These findings provided a rational reason to establish the isolated compounds capability as therapeutic target for hyperglycaemia modulation and antifungal therapy.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Sahnoun M,Bejar S,Daoud L,Ayadi L,Brini F,Saibi W

doi

10.1080/14786419.2017.1408094

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

755-758

issue

5

eissn

1478-6419

issn

1478-6427

journal_volume

33

pub_type

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