Abstract:
:A new indole diterpene, named penicindopene A (1), together with seven known compounds (2 - 8), was isolated from the deep-sea fungus Penicillium sp. YPCMAC1. The structure of penicindopene A was elucidated by extensive spectroscopic analyses (1 D and 2 D NMR, and HRESIMS data), in addition to the ECD calculations for the assignments of its absolute configuration. Penicindopene A represented the first example of indole diterpenes possessing a 3-hydroxyl-2-indolone moiety, and it exhibited moderate cytotoxicities against A549 and HeLa cell lines with IC50 values of 15.2 and 20.5 µM, respectively.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Liu L,Xu W,Li S,Chen M,Cheng Y,Yuan W,Cheng Z,Li Qdoi
10.1080/14786419.2018.1514402subject
Has Abstractpub_date
2019-10-01 00:00:00pages
2988-2994issue
20eissn
1478-6419issn
1478-6427journal_volume
33pub_type
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