Salvia x jamensis J. Compton: Trichomes, essential oil constituents and cytotoxic-apoptotic activity.

Abstract:

:Salvia x jamensis J. Compton is a hybrid between Salvia greggii A. Gray and Salvia microphylla Kunt. In this study, we describe three hair types identified by Scanning Electron Microscopy. In the essential oil of the aerial parts of S. jamensis 56 different compounds were identified. The two main constituents were β-caryophyllene (14.8%) and β-pinene (6.8%). Cytotoxic-apoptotic activity of S. x jamensis essential oil has been investigated by using U937 cell line. The essential oil EC50 for cell number and for cell apoptosis have been shown to be 360 and 320 µg mL(-1), respectively. Among the constituents of the oil examined, only β-caryophyllene, β-pinene and α-pinene displayed cytotoxic and apoptotic activities. For the first time, it has been demonstrated that some of the pure constituents identified within S. x jamensis essential oil are responsible for its cytotoxic-apoptotic activity when properly combined.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Fraternale D,Albertini MC,Rudov A,Flamini G,Ricci D,Bisio A,Battistelli M,Accorsi A

doi

10.1080/14786419.2012.730044

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

1583-8

issue

17

eissn

1478-6419

issn

1478-6427

journal_volume

27

pub_type

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