Abstract:
:Three Ballota species, Ballota undulata, Ballota saxatilis and Ballota nigra ssp. foetida, were investigated for their cytotoxicity against two human cancer cells, hepatoma HepG2 cell line and breast cancer MCF-7 cell line, and for their antioxidant activity. The chemical composition of essential oils was studied by GC and GC-MS. Sesquiterpenes were the main constituents. The most antiproliferative essential oil against HepG2 cells was B. undulata with a percentage of inhibition of 81.36 ± 3.54 at a concentration of 100 μg/mL, while against MCF-7 cells essential oil from B. saxatilis was the most active with a percentage of inhibition of 24.18 ± 1.13 at a concentration of 100 μg/mL. The antioxidant activity was investigated by DPPH test for all the oils. B. undulata showed the highest antiradical effect, with IC50 value of 529.7 ± 37.4 μg/mL.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Rigano D,Marrelli M,Formisano C,Menichini F,Senatore F,Bruno M,Conforti Fdoi
10.1080/14786419.2016.1185722subject
Has Abstractpub_date
2017-02-01 00:00:00pages
436-444issue
4eissn
1478-6419issn
1478-6427journal_volume
31pub_type
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