Phytochemical profile of three Ballota species essential oils and evaluation of the effects on human cancer cells.

Abstract:

:Three Ballota species, Ballota undulata, Ballota saxatilis and Ballota nigra ssp. foetida, were investigated for their cytotoxicity against two human cancer cells, hepatoma HepG2 cell line and breast cancer MCF-7 cell line, and for their antioxidant activity. The chemical composition of essential oils was studied by GC and GC-MS. Sesquiterpenes were the main constituents. The most antiproliferative essential oil against HepG2 cells was B. undulata with a percentage of inhibition of 81.36 ± 3.54 at a concentration of 100 μg/mL, while against MCF-7 cells essential oil from B. saxatilis was the most active with a percentage of inhibition of 24.18 ± 1.13 at a concentration of 100 μg/mL. The antioxidant activity was investigated by DPPH test for all the oils. B. undulata showed the highest antiradical effect, with IC50 value of 529.7 ± 37.4 μg/mL.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Rigano D,Marrelli M,Formisano C,Menichini F,Senatore F,Bruno M,Conforti F

doi

10.1080/14786419.2016.1185722

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

436-444

issue

4

eissn

1478-6419

issn

1478-6427

journal_volume

31

pub_type

杂志文章
  • Enhancement of phenolic and flavonoids compounds, antioxidant and cytotoxic effects in regenerated red cabbage by application of Zeatin.

    abstract::This study evaluated the roles of zeatin (2 mg/L) on direct organogenesis, phytochemical compounds, antioxidant activity, and cytotoxic activity in regenerated shoots of red cabbage. The results revealed that the extract of explant treated by 2 mg/L zeatin gives the highest content of total phenolics (5.18 mg gallic a...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1508145

    authors: Ravanfar SA,Karimi E,Mehrabanjoubani P,Ebrahimi M

    更新日期:2020-03-01 00:00:00

  • A new insecticidal havanensin-type limonoid from the roots of Trichilia sinensis Bentv.

    abstract::One new havanensin-type limonoid (1) named trisinlin A with two known compounds (4E,8E)-2-[2'-hydroxyhexadecanoyl amino]-4,8-octadecadiene-1,3-diol (2), 9-octadecenoic acid-2',3'-dihydroxypropyl ester (3) were isolated from the roots of Trichilia sinensis. The structure of the new compound was unambiguously determined...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1380016

    authors: Liu SB,Chen HQ,Feng G,Guo ZK,Cai CH,Wang J,Mei WL,Dai HF

    更新日期:2018-12-01 00:00:00

  • Microcalorimetric study of the effect of Benzoinum and Styrax on the growth of Escherichia coli.

    abstract::In this study, the effects of Benzoinum and Styrax on Escherichia coli (E. coli) growth were investigated by microcalorimetry. Using a TAM Air Isothermal Calorimeter, ampoule method, the power-time curves of E. coli growth at 37°C affected by Benzoinum and Styrax were measured. By analysing some quantitative thermokin...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.533670

    authors: Wang J,Cheng D,Zeng N,Xia H,Fu Y,Yan D,Zhao Y,Xiao X

    更新日期:2011-02-01 00:00:00

  • Effect of Asteracantha longifolia seeds on the sexual behaviour of male rats.

    abstract::The aim of the present study was to study the effect of seeds of Asteracantha longifolia on the sexual behaviour of male albino rats. The ethanolic extract of seeds of A. longifolia was administered to groups of rats in 100, 150 and 200 mg kg⁻¹ doses for a period of 28 days, and the action compared with control rats. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410802588493

    authors: Chauhan NS,Sharma V,Dixit VK

    更新日期:2011-09-01 00:00:00

  • Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents.

    abstract::As part of continuing our research on diverse C-7 derivatives of camptothecin (CPT), 16 CPT derivatives bearing piperazinyl-thiourea chemical scaffold and different substituent groups have been designed, synthesized and evaluated in vitro for cytotoxicity against five tumor cell lines (A-549, MDA-MB-231, MCF-7, KB and...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1573231

    authors: Song ZL,Yang GZ,Li JC,Liu YQ,Yang CJ,Goto M,Zhang ZJ,Morris-Natschke SL,Liu H,Lee KH

    更新日期:2020-07-01 00:00:00

  • Chemistry of α-mangostin. Studies on the semisynthesis of minor xanthones from Garcinia mangostana.

    abstract::α-Mangostin is the major prenylated xanthone from Garcinia mangostana and it has been used also in recent times as starting material for the semisynthetic preparation of various biologically active derivatives. Its structure is characterised by the presence of few functional groups amenable to chemical manipulations, ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.986729

    authors: Morelli CF,Biagiotti M,Pappalardo VM,Rabuffetti M,Speranza G

    更新日期:2015-01-01 00:00:00

  • Three new secoiridoid glycosides from the rhizomes and roots of Gentiana scabra and their anti-inflammatory activities.

    abstract::Three new (1-3) and 17 known (4-20) iridoid and secoiridoid glycosides were isolated from a methanol extract of the rhizomes and roots of Gentiana scabra. Their chemical structures were elucidated from 1D and 2D NMR, IR absorption, and HR-ESI-MS spectra, as well as comparisons of these data with reported values. The e...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2015.1013955

    authors: Li W,Zhou W,Kim S,Koo JE,Kim Y,Koh YS,Shim SH,Ma JY,Kim YH

    更新日期:2015-01-01 00:00:00

  • Free radical-scavenging activities of Homalium species--An endangered medicinal plant of Eastern Ghats of India.

    abstract::Three species of the genus Homalium - e.g. Homalium nepalense, Homalium tomentosum and Homalium zeylanicum (Flacourtiaceae) - are recorded in India which are confined to the Eastern Ghat hill ranges. While H. zeylanicum is the IUCN red-listed medium-sized tree, the other two are endangered species of medicinal signifi...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.987142

    authors: Mahapatra AK,Pani SS,Sahoo AK

    更新日期:2015-01-01 00:00:00

  • Phenolic and antioxidant profiles of rowan (Sorbus L.) fruits.

    abstract::Fruits of different Sorbus L. species have been traditionally used in food production and in the treatment of various ailments. Besides common antioxidant active phytochemicals such as ascorbic acid, tocopherols and carotenoids, fruits are rich in phenolic compounds that are of particular interest. In this study, prof...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.895727

    authors: Raudonis R,Raudonė L,Gaivelytė K,Viškelis P,Janulis V

    更新日期:2014-01-01 00:00:00

  • Two new benzoic acid derivatives from endophytic fungus Aspergillus versicolor.

    abstract::Two new benzoic acid derivatives, named methyl(S)-3-hydroxy-4-(2- hydroxy -6-methylheptan-2-yl)benzoate (1) and 2-hydroxy-3-(6- hydroxy-6-methylhept-1-en-2-yl)benzoic acid (2), were isolated from the ethanol extract of an endophytic fungus Aspergillus versicolor derived from the medicinal plant Euphorbia royleana. The...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1777121

    authors: Ye Y,Chen Y,Hou Y,Yu H,Zhu L,Sun Y,Zhou M,Chen Y,Dong M

    更新日期:2020-06-11 00:00:00

  • Detection of flavonoids from Spinacia oleracea leaves using HPLC-ESI-QTOF-MS/MS and UPLC-QqQLIT-MS/MS techniques.

    abstract::Spinacia oleracea L. (Spinach) is a leafy vegetable which is considered to have a high nutritional value. Flavonoids in spinach were reported to act as antimutagenic property. Rapid detection of these flavonoids in Spinach was achieved by using HPLC-ESI-QTOF-MS/MS. Thirty six compounds were tentatively identified base...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1489395

    authors: Singh A,Singh P,Kumar B,Kumar S,Dev K,Maurya R

    更新日期:2019-08-01 00:00:00

  • Chemical composition, in vitro antioxidant and antibacterial activities of Centaurea resupinata subsp. dufourii (dostál) greuter.

    abstract::The current study focuses on the chemical composition, and evaluation of antioxidant and antibacterial activity of the aerial parts of Centaurea resupinata subsp. dufourii. Using different chromatographic methods nine compounds 1-9 were isolated. The structural identification of isolated compounds was achieved using s...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1715397

    authors: Bouzghaia B,Moussa MTB,Goudjil R,Harkat H,Pale P

    更新日期:2020-01-23 00:00:00

  • Two new polyketides isolated from a diethyl sulphate mutant of marine-derived Penicillium purpurogenum G59.

    abstract::Two new polyketides, purpurofuranone (1) and purpuropyranone (2), were isolated along with the known polyketides, cillifuranone (3) and taiwapyrone (4), from a mutant BD-3n-1 derived from the diethyl sulfate (DES) mutagenesis of a marine-derived Penicillium purpurogenum G59. The structures of 1 and 2 were elucidated b...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1514397

    authors: Wu CJ,Qiao H,Cui CB,Yang Y,Xu R,Sun CX,Li DH,Li CW

    更新日期:2019-10-01 00:00:00

  • Components characterisation of Berchemia lineata (L.) DC. by UPLC-QTOF-MS/MS and its metabolism with human liver microsomes.

    abstract::Investigations were performed on the determination of the main components in Berchemia lineata (L.) DC. (BL) and its metabolism with human liver microsomes (HLM). A total of 35 compounds were detected in BL extracts and 25 of them including 6 naphthopyrones, 10 flavonoids, 2 phenolic acids, 2 phenols, 4 fatty acids an...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1637871

    authors: Jiang X,Chen S,Guo Z,Gu D,Liang X

    更新日期:2021-02-01 00:00:00

  • Isopimarane-type diterpenoids from Croton laevigatus.

    abstract::A new isopimarane-type diterpenoid, crolaevinoid A, along with four known analogues was isolated from the twigs and leaves of Croton laevigatus. The structures of the isolated compounds were established on the basis of NMR and MS spectroscopic analyses. The isolated compounds were examined the antibacterial activities...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1596096

    authors: Li MY,Han ZZ,Liu LF,Wu XZ,Huang WJ,Wang K,Yang F,Yuan CS

    更新日期:2020-10-01 00:00:00

  • Bioactivity and chemistry of the genus Hortonia.

    abstract::The dichloromethane extracts of the leaves, stem bark, bark and the roots of the three species of the primitive endemic genus Hortonia, H. angustifolia, H. floribunda and H. ovalifolia, collected from nine geographical locations ranging from lower elevations (84-420 m) to higher (2000 m) showed comparable HPLC profile...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410701722433

    authors: Ratnayake R,Ratnayake Bandara BM,Wijesundara S,Macleod JK,Simmonds P,Karunaratne V

    更新日期:2008-01-01 00:00:00

  • Isolation, structural elucidation and antiplasmodial activity of fucosterol compound from brown seaweed, Sargassum linearifolium against malarial parasite Plasmodium falciparum.

    abstract::The brown seaweed, Sargassum linearifolium (Turner) C. Agardh, 1820 is commonly available along the south-east coast of India. Its compound fucosterol was isolated and confirmed through spectral characterisation and chemical transformation methods. The antiplasmodial effect of the isolated fucosterol was investigated ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1342081

    authors: Perumal P,Sowmiya R,Prasanna Kumar S,Ravikumar S,Deepak P,Balasubramani G

    更新日期:2018-06-01 00:00:00

  • Tectona grandis (teak) - A review on its phytochemical and therapeutic potential.

    abstract::Tectona grandis Linn (Teak), is locally known as Sagwan, belongs to Lamiaceae family. It is one of the most valuable timber in the world, due to its beautiful surface and its resistance to termite and fungal damage. The main active ingredient compounds that are responsible for these action are tectoquinone, lapachol a...

    journal_title:Natural product research

    pub_type: 杂志文章,评审

    doi:10.1080/14786419.2018.1440217

    authors: Vyas P,Yadav DK,Khandelwal P

    更新日期:2019-08-01 00:00:00

  • Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood, a new chemotype from Montenegro.

    abstract::A study on essential oil fractions of the Western Balkan endemic Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood collected in Montenegro is reported. The 24-h systematic steam distillation extraction procedure was performed. The gas chromatographic/mass spectrometric (GC/MS) analysis of the fractions show...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1378212

    authors: Garzoli S,Božović M,Baldisserotto A,Andreotti E,Pepi F,Tadić V,Manfredini S,Ragno R

    更新日期:2018-05-01 00:00:00

  • Characteristics of fatty acids and essential oil from sweet fennel (Foeniculum vulgare Mill. var. dulce) and bitter fennel fruits (F. vulgare Mill. var. vulgare) growing in Turkey.

    abstract::Oil content in sweet and bitter fennels was obtained 12.22% and 14.41%, respectively. The C(18:1 c6), C(18:2), C(18:1 c9) and C(16:0) acids corresponding to approximately 97% of total oil was recorded as principal fatty acids. The ratios of essential oil from sweet and bitter fennels were found similar (average 3.00%)...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410801980675

    authors: Coşge B,Kiralan M,Gürbüz B

    更新日期:2008-01-01 00:00:00

  • (3Z)-Bromofucin from a South African sea hare.

    abstract::Specimens of the cosmopolitan sea hare Aplysia parvula, collected in the Tsistsikamma National Park on the south-east coast of South Africa yielded the new dibromo-C15-acetogenin, (3Z)-bromofucin (1). Standard spectroscopic methods were used to establish the structure of this compound. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410412331271960

    authors: McPhail KL,Davies-Coleman MT

    更新日期:2005-07-01 00:00:00

  • Two new ditetrahydrofuran lignans from Artemisia sieversiana.

    abstract::Two new ditetrahydrofuran lignans, named sieverlignans A and B (1 and 2), together with six known ones (3-8), were isolated from the aerial parts of Artemisia sieversiana. Their structures were established on the basis of spectroscopic analysis including HRMS, NMR spectra and circular dichroism experiments. All the co...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1712384

    authors: Zhou XD,Xu XW,Shi LY,Chen SH,Zeng KW,Tu PF

    更新日期:2020-01-13 00:00:00

  • An isoindole alkaloid from Portulaca oleracea L.

    abstract::A novel isoindole alkaloid named oleraisoindole (1), together with six known compounds, 7'-ethoxy-trans-feruloyltyramine (2), N-trans-feruloyltyramine (3), N-trans-feruloyl-3-methoxytyramine (4), N-trans-p-coumaroyltyramine (5) aurantiamide (6) and ferulic acid methyl ester (7) were isolated from Portulaca oleracea L....

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1419226

    authors: Jiang M,Zhang W,Yang X,Xiu F,Xu H,Ying X,Stien D

    更新日期:2018-10-01 00:00:00

  • One new anthraquinone from marine Streptomyces sp. FX-58.

    abstract::One new anthraquinone, 1,8-dihydroxy-2-ethyl-3-methylanthraquinone (1), together with two known compounds octadecanoic acid (2) and cholest-4-en-3-one (3) was isolated from marine actinomycete Streptomyces sp. FX-58. The structure of 1 was elucidated on the basis of spectroscopic methods, especially, the 2D-NMR spectr...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410600899142

    authors: Huang YF,Tian L,Fu HW,Hua HM,Pei YH

    更新日期:2006-11-01 00:00:00

  • Matrix solid-phase dispersion as a tool for phytochemical and bioactivities characterisation: Crataegus oxyacantha L._A case study.

    abstract::The use of a matrix solid-phase dispersion (MSPD) process to extract polyphenols from hawthorn (Crataegus oxyacantha L.) a deciduous shrub with an expected rich phytochemical profile, has been evaluated. MSPD extracts of fruits and leaves have an outstanding content of polyphenols, although the particular phenolic pro...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1326040

    authors: Benabderrahmane W,Lores M,Lamas JP,Benayache S

    更新日期:2018-05-01 00:00:00

  • Bioactive triterpenoids from the leaves of Eriobotrya japonica as the natural PDE4 inhibitors.

    abstract::The ethanolic extract of the leaves of Eriobotrya japonica exhibited inhibitory activity against phosphodiesterase-4D (PDE4D), which is a therapeutic target of inflammatory disease. Subsequent bioassay-guided fractionation led to the isolation of a new triterpene (1), together with seven known triterpenoids, methyl co...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1300796

    authors: Tan BX,Yang L,Huang YY,Chen YY,Peng GT,Yu S,Wu YN,Luo HB,He XX

    更新日期:2017-12-01 00:00:00

  • Ascomycotin A, a new citromycetin analogue produced by Ascomycota sp. Ind19F07 isolated from deep sea sediment.

    abstract::A new citromycetin analogue, ascomycotin A (1), together with eight known compounds, wortmannilactone E (2), orcinol (3), orsellinic acid (4), isosclerone (5), (3R,4S)-( - )-4-hydroxymellein (6), diorcinol (7), chaetocyclinone B (8) and 2,5-dimethoxy-3,6-di(p-methoxypheny1)-1,4-benzoquinone (9), was isolated from the ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.988620

    authors: Tian YQ,Lin XP,Liu J,Kaliyaperumal K,Ai W,Ju ZR,Yang B,Wang J,Yang XW,Liu Y

    更新日期:2015-01-01 00:00:00

  • An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure-activity correlations.

    abstract::N-methylasimilobine (1), a new-found strong acetylcholinesterase (AChE) inhibitor, along with two weakly active aporphine alkaloids, nuciferine (2) and nornuciferine (3) were separated from Nelumbo nucifera. N-methylasimilobine (1) inhibited 50% of AChE activity at the concentrations of 1.5 ± 0.2 µg mL(-1) when the st...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.487188

    authors: Yang ZD,Zhang X,Du J,Ma ZJ,Guo F,Li S,Yao XJ

    更新日期:2012-01-01 00:00:00

  • Isolation of a new monoterpenic ester from the leaves of Michelia compressa (Maxim.) Sargent var. formosana Kanehira (Magnoliaceae).

    abstract::Pressafonin A (1) and pressafonin B (2), two new Michelia monoterpenic esters, have been isolated from Michelia compressa (Maxim.) Sargent var. formosana Kanehira (Magnoliaceae), and their structures are determined on the basis of spectroscopic analysis. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410903281774

    authors: Cheng MJ,Lo WL,Huang JC,Yeh YT,Hong ZL,Lu YC,Chang MS,Chen CY

    更新日期:2010-04-01 00:00:00

  • Bioactive metabolites of hass and reed avocados targeting methicillin-resistant Staphylococcus aureus enterotoxin-like X via molecular modeling and cytotoxicity assessments.

    abstract::The aim of this study is to estimate the nutritive values, metabolites of Hass and Reed Avocado cultivars and evaluate their antimicrobial and anticancer activities. Hass was rich in water soluble vitamins, iron and calcium while, Reed contains more fat soluble vitamins. Benzaldehyde and butyl phenol derivatives were ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1817013

    authors: Younis IY,Hifnawy MS,El-Hawary SS,El Bishbishy MH,Elateek SY

    更新日期:2020-09-11 00:00:00