Abstract:
:N-methylasimilobine (1), a new-found strong acetylcholinesterase (AChE) inhibitor, along with two weakly active aporphine alkaloids, nuciferine (2) and nornuciferine (3) were separated from Nelumbo nucifera. N-methylasimilobine (1) inhibited 50% of AChE activity at the concentrations of 1.5 ± 0.2 µg mL(-1) when the standard IC(50) value of Physostigmine was 0.013 ± 0.002 µg mL(-1). The mode of AChE inhibition by 1 was reversible and non-competitive. In addition, molecular modelling was performed to explore the binding mode of inhibitor 1 at the active site of AChE.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Yang ZD,Zhang X,Du J,Ma ZJ,Guo F,Li S,Yao XJdoi
10.1080/14786419.2010.487188subject
Has Abstractpub_date
2012-01-01 00:00:00pages
387-92issue
5eissn
1478-6419issn
1478-6427journal_volume
26pub_type
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